Rabeprazole
Duodenal Ulcer, Gastroesophageal Reflux ... show more
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Proton Pump Inhibitor
Controlled Drug Substance
NO

Rabeprazole
Summary
Rabeprazole is used to treat gastroesophageal reflux disease (GERD), stomach ulcers, and Zollinger-Ellison syndrome, which causes excessive stomach acid. It's also used to treat infections caused by Helicobacter pylori bacteria and to heal esophagitis, which is damage to the esophagus caused by stomach acid. It can also prevent ulcers caused by nonsteroidal anti-inflammatory drugs (NSAIDs).
Rabeprazole works by blocking the proton pump in the cells of your stomach. This pump is responsible for producing stomach acid. By blocking it, Rabeprazole reduces the amount of acid in your stomach, which can relieve symptoms like heartburn and indigestion, and promote healing of the digestive tract.
The usual adult dosage of Rabeprazole is 20 mg once daily, taken before a meal. For conditions like GERD or ulcers, treatment is typically continued for 4-8 weeks depending on the condition. Rabeprazole should be taken whole, not crushed or chewed, and with a full glass of water.
Common side effects of Rabeprazole include headache, diarrhea, nausea, and abdominal pain. Serious, but rare, side effects may include allergic reactions, liver problems, and an increased risk of bone fractures with long-term use. Prolonged use can also lead to vitamin B12 deficiency and an increased risk of gastrointestinal infections.
Rabeprazole should be used with caution in individuals with liver disease. It is not recommended for people who are allergic to Rabeprazole or other proton pump inhibitors. Long-term use can increase the risk of bone fractures, vitamin B12 deficiency, and gastrointestinal infections. It should also be avoided in people with low magnesium levels or a history of severe allergic reactions to PPIs.
Indications and Purpose
How does Rabeprazole work?
Rabeprazole works by inhibiting the proton pump in the stomach lining, which is responsible for secreting stomach acid. By blocking this pump, Rabeprazole reduces the amount of acid produced in the stomach. This helps alleviate symptoms of acid reflux, promotes healing of ulcers, and prevents damage to the esophagus or stomach lining caused by excessive acid. It also reduces irritation and inflammation associated with conditions like GERD.
Is Rabeprazole effective?
Clinical studies have shown that Rabeprazole effectively reduces stomach acid production, providing relief from symptoms of GERD, ulcers, and other acid-related conditions. Research indicates it helps heal erosive esophagitis, promotes ulcer healing, and is effective in combination therapies for H. pylori eradication. Its ability to suppress acid production and improve patient outcomes in acid reflux and ulcer management has been well-documented in clinical trials.
What is Rabeprazole?
Rabeprazole is a proton pump inhibitor (PPI) commonly used to treat conditions like gastroesophageal reflux disease (GERD), stomach ulcers, and Zollinger-Ellison syndrome. It works by reducing the amount of stomach acid produced, helping to relieve symptoms like heartburn, indigestion, and acid-related damage to the stomach lining. Rabeprazole blocks the proton pump in the stomach cells, preventing acid secretion and promoting healing of the digestive tract.
Directions for Use
For how long do I take Rabeprazole?
- Gastroesophageal Reflux Disease (GERD): Treatment usually lasts 4 to 8 weeks. If symptoms persist after 8 weeks, an additional 8-week course may be considered.
- Erosive Esophagitis: Generally prescribed for up to 8 weeks, with a possibility of extending treatment if healing is not achieved.
- Duodenal Ulcers: Typically treated for 4 weeks, with an option for an additional course if needed.
- Maintenance Therapy: For maintaining healing, rabeprazole can be used for up to 12 months. Long-term safety beyond this duration has not been established.
How do I dispose of Rabeprazole?
If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.
How do I take Rabeprazole?
Rabeprazole should be taken before a meal, typically once daily, to maximize its effectiveness in reducing stomach acid. It can be taken with or without food, but taking it on an empty stomach is generally recommended for optimal results. There are no specific food restrictions, but it's advisable to avoid foods that may irritate your stomach, such as spicy or acidic foods, while undergoing treatment. Always follow the instructions provided by your healthcare provider.
How long does it take for Rabeprazole to start working?
Rabeprazole usually starts working within 1 to 2 hours after taking it, providing relief from acid-related symptoms like heartburn. However, it may take a few days of consistent use to achieve the full therapeutic effect, particularly in treating conditions like GERD or ulcers. For optimal results, it's important to follow the prescribed dosage and duration of treatment.
How should I store Rabeprazole?
Rabeprazole should be stored at room temperature, away from heat, moisture, and direct sunlight. Keep the medication in its original container, tightly closed, and out of reach of children. Do not store it in a bathroom or humid environment, as moisture can affect the integrity of the tablets. Always check the expiration date before use and dispose of any unused medication properly.
What is the usual dose of Rabeprazole?
Rabeprazole sodium delayed-release tablets are not suitable for children under 12 years old. The strength of the tablet is too high for this age group. Instead, younger children (aged 1 to 11) should use alternative rabeprazole formulations that are tailored to their specific needs. The dosage and duration of treatment will vary depending on the reason for taking the medication. Always consult with a healthcare professional for the most appropriate dosage and duration of treatment.
Warnings and Precautions
Can I take Rabeprazole with other prescription drugs?
Rabeprazole can interact with several prescription drugs. It may reduce the effectiveness of certain drugs that require stomach acid for absorption, such as ketoconazole, itraconazole, and atazanavir. It can also increase the blood levels of drugs like methotrexate and diazepam, potentially leading to side effects. Additionally, combining Rabeprazole with warfarin may increase the risk of bleeding. Always inform your healthcare provider about all medications you're taking to avoid harmful interactions.
Can Rabeprazole be taken safely while breastfeeding?
Rabeprazole is excreted into breast milk in small amounts, but there is limited data on its effects on breastfeeding infants. It is generally considered safe for use during lactation, especially when the benefits to the mother outweigh potential risks. However, nursing mothers should consult their healthcare provider to ensure the medication is appropriate for their condition and to monitor for any potential adverse effects on the infant.
Can Rabeprazole be taken safely while pregnant?
Rabeprazole is classified as a Category C drug for pregnancy, meaning that while animal studies have shown no harm, there are insufficient human studies to confirm its safety during pregnancy. It should only be used during pregnancy if the potential benefits outweigh the risks. Pregnant women should consult a healthcare provider before taking Rabeprazole to ensure it is necessary and safe for their condition.
Does Rabeprazole have adverse effects?
Adverse effects, which are unwanted or harmful reactions to a medicine, can occur with any medication. For this medicine, common adverse effects might include nausea, headache, dizziness, fatigue, and dry mouth. These effects can vary in frequency, with some people experiencing them more often than others. Rare but serious adverse effects could include severe allergic reactions, which might cause difficulty breathing or swelling of the face and throat, and require immediate medical attention. It's crucial to report any new or worsening symptoms to a healthcare provider. Never stop taking a medicine without consulting a healthcare professional, as they can provide guidance on managing side effects or adjusting treatment if necessary.
Does Rabeprazole have any safety warnings?
This medicine does have safety warnings. One key warning is the risk of allergic reactions, which can occur if you are allergic to any of the ingredients. Allergic reactions can lead to symptoms like rash, itching, swelling, severe dizziness, or trouble breathing. If you notice any of these symptoms, seek medical help immediately. Another warning is the potential for liver damage, which can happen if the medicine is taken in high doses or for a long time. Signs of liver damage include yellowing of the skin or eyes, dark urine, or severe stomach pain. It's important to monitor for these symptoms and consult a doctor if they appear. Lastly, this medicine may cause dizziness or drowsiness, which can affect your ability to drive or operate machinery. If you feel dizzy or drowsy, avoid these activities to prevent accidents.
Is it safe to drink alcohol while taking Rabeprazole?
Drinking alcohol while taking Rabeprazole can irritate the stomach and interfere with the medication’s ability to heal ulcers or treat acid reflux effectively. It’s best to limit alcohol intake to ensure full treatment benefits.
Is it safe to exercise while taking Rabeprazole?
It is generally safe to exercise while taking Rabeprazole. Just ensure that you don't push yourself too hard if you experience fatigue or stomach discomfort. Always stay hydrated and listen to your body. If you experience symptoms like dizziness, consult your doctor.
Is it safe to stop Rabeprazole?
To determine if it's safe to stop a medicine, first consider its purpose. If it's for managing a chronic condition like hypertension or diabetes, stopping it suddenly can lead to serious health risks, such as uncontrolled blood pressure or blood sugar levels. If the medicine is for symptomatic relief or treating a temporary condition, like an infection, stopping it might lead to a return of symptoms or incomplete treatment. Some medicines can cause withdrawal symptoms or rebound effects, where symptoms return worse than before. Abruptly stopping certain medicines can be life-threatening, especially those affecting the heart or brain. Always consult a doctor before stopping any medicine to ensure it's done safely and appropriately.
Is Rabeprazole addictive?
This medicine does not have any known potential for dependence or addiction. It is considered safe in terms of habit-forming properties. Therefore, there is no need to worry about developing a physical or psychological dependence on this medication. However, it is always important to follow the prescribed dosage and instructions provided by your healthcare provider to ensure safe and effective use. If you have any concerns or experience any unusual symptoms, it is advisable to consult with your doctor for further guidance.
Is Rabeprazole safe for the elderly?
- Increased Sensitivity: Elderly patients may be more sensitive to the effects of rabeprazole compared to younger adults, necessitating careful monitoring.
- No Specific Limitations: Current studies have not identified geriatric-specific problems that would limit the use of rabeprazole in older adults.
- Long-term Use Caution: Prolonged use may lead to risks such as weakened bones due to reduced calcium and magnesium levels. Supplementation may be necessary.
- Regular Monitoring: Regular follow-ups are essential to assess efficacy and any potential adverse effects, especially in those with comorbidities.
What are the most common side effects of Rabeprazole?
A side effect is an unwanted or unexpected symptom caused by a medicine. For this medicine, common side effects may include nausea, which is feeling sick to your stomach, dizziness, which is feeling lightheaded or unsteady, headache, which is pain in the head, fatigue, which is feeling very tired, and dry mouth, which is a lack of saliva. The frequency of these side effects can vary, but they are generally not experienced by everyone. It's important to note that when starting a new medicine, people might experience new symptoms that could be unrelated to the medicine, temporary, or due to another health issue. Always talk to a healthcare provider before stopping any medicine, as they can provide guidance on managing side effects and ensure your treatment is safe and effective.
Who should avoid taking Rabeprazole?
Rabeprazole should be used with caution in individuals with liver disease, as it may affect liver function. It is contraindicated in people who are allergic to Rabeprazole or other proton pump inhibitors. Long-term use can increase the risk of bone fractures, vitamin B12 deficiency, and gastrointestinal infections like Clostridium difficile. It should also be avoided in people with low magnesium levels or a history of severe allergic reactions to PPIs. Always follow healthcare provider guidance when using this medication.