Progesterone

What is Progesterone used for?

Progesterone is used for hormone replacement therapy (HRT) in menopause, pregnancy support, menstrual disorders, endometrial protection, and endometriosis. It also helps in preventing preterm birth in some cases.

How does Progesterone work?

Progesterone works by mimicking the natural hormone progesterone in the body. It plays a key role in regulating the menstrual cycle, preparing the uterus for implantation of a fertilized egg, and maintaining pregnancy by preventing uterine contractions. In hormone replacement therapy (HRT), it balances the effects of estrogen and protects the uterus from potential risks like endometrial cancer.

Is Progesterone effective?

Clinical studies support the effectiveness of Progesterone in various conditions. For menstrual disorders, it has been shown to regulate cycles and reduce abnormal bleeding. In pregnancy support, it helps maintain uterine lining, reducing the risk of miscarriage. Evidence also confirms its role in HRT, improving menopause symptoms and protecting the endometrium. These benefits are well-documented in research and clinical practice.

How does one know if Progesterone is working?

The benefits of Progesterone are evaluated by monitoring improvements in symptoms such as menstrual regularity, pregnancy maintenance, and menopause symptom relief. For pregnancy support, doctors check hormone levels and ultrasound scans. In HRT, doctors assess symptom relief and ensure the uterine lining remains protected. Evaluation involves blood tests, patient symptom tracking, and medical exams.

What is the usual dose of Progesterone?

This medicine's dosage depends on why you're taking it and your age. For adult women with certain conditions, the amount is different. For preventing a specific uterine problem after menopause, the dose is 200mg nightly for 12 days out of every 28. For another condition (lack of periods), the dose is higher (400mg nightly) for 10 days. This medicine isn't meant for children.

How do I take Progesterone?

Progesterone can be taken with or without food. However, taking it with food may help reduce any stomach upset. There are no specific food restrictions when using Progesterone, but it is recommended to follow your doctor’s advice regarding dosage timing and any lifestyle adjustments.

For how long do I take Progesterone?

• Endometrial Hyperplasia Prevention: Use in 28-day cycles as prescribed by your healthcare provider.
• Secondary Amenorrhea: For 10 days per treatment cycle, or as directed by your healthcare provider​

How long does it take for Progesterone to start working?

The effects of Progesterone can be felt within a few days to weeks, depending on the condition being treated. For menstrual disorders, it may take a few days to regulate the cycle. For pregnancy support, it helps maintain the uterine lining, and its effects are monitored over weeks. The full benefits, especially in HRT, may take several weeks to become evident.

How should I store Progesterone?

Progesterone needs to be kept at a temperature between 68° to 77°F (20° to 25°C). This is the recommended storage temperature to maintain the effectiveness of the medication.

Who should avoid taking Progesterone?

Warnings for Progesterone include caution in individuals with a history of blood clots, liver disease, or breast cancer. It should be used cautiously in people with depression or heart disease.

Contraindications include active liver disease, unexplained vaginal bleeding, and allergy to progesterone. It should also be avoided in pregnancy unless prescribed for support. Always consult a doctor before use.

Can I take Progesterone with other prescription drugs?

1. Anticoagulants (e.g., warfarin): Progesterone may reduce the effectiveness of blood thinners, increasing the risk of clotting.
2. CYP450 enzyme inhibitors (e.g., ketoconazole, ritonavir): These can increase progesterone levels, potentially enhancing side effects.
3. Anticonvulsants (e.g., phenytoin, carbamazepine): These may reduce progesterone levels, lowering its effectiveness.

Can I take Progesterone with vitamins or supplements?

Progesterone has minimal interactions with vitamins or supplements. However, taking vitamin E in high doses may increase the risk of blood clots when combined with progesterone, as both can have anticoagulant effects. It’s advisable to monitor the use of herbal supplements like St. John's Wort, which may decrease progesterone's effectiveness. Always consult a healthcare provider before combining supplements with progesterone.

Can Progesterone be taken safely while pregnant?

Progesterone is commonly used during pregnancy to support the uterine lining and prevent miscarriage, particularly in women with a history of pregnancy loss or luteal phase defects. It is generally considered safe when used as prescribed during pregnancy. However, its use should be monitored to avoid potential side effects. Consult a healthcare provider for individualized guidance.

Can Progesterone be taken safely while breastfeeding?

Progesterone is excreted in breast milk in small amounts, but it is generally considered safe for use during lactation. There is no significant evidence suggesting that it negatively affects the infant. However, if high doses or long-term use is required, it’s important to consult a healthcare provider to ensure it’s the best choice while breastfeeding.

Is Progesterone safe for the elderly?

For women over 65, using progesterone alone or with estrogen hasn't been proven safe or helpful. In fact, combining estrogen and progesterone can increase the chances of stroke, breast cancer, and possibly dementia. Doctors don't recommend this combination to prevent heart problems or dementia.

Is it safe to exercise while taking Progesterone?

Exercise is generally safe. Avoid strenuous activities if dizziness or fatigue occurs​.

Is it safe to drink alcohol while taking Progesterone?

Alcohol may worsen drowsiness or dizziness. Avoid combining them​.