Pralsetinib
Non-Small-Cell Lung Carcinoma
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Summary
Pralsetinib is used to treat certain types of cancer, such as non-small cell lung cancer, which is a type of lung cancer that starts in the cells lining the lungs, with specific genetic mutations, which are changes in the DNA sequence of a gene.
Pralsetinib works by blocking proteins, which are molecules that help cancer cells grow. This action slows down or stops the growth of the cancer, helping to control the disease.
The usual starting dose of Pralsetinib for adults is 400 mg once daily. It should be taken on an empty stomach, which means at least 1 hour before or 2 hours after a meal, and swallowed whole with water.
Common side effects of Pralsetinib include fatigue, which is a feeling of tiredness, constipation, which is difficulty in passing stools, and high blood pressure, which is when the force of blood against artery walls is too high.
Pralsetinib can cause serious lung problems, liver damage, and high blood pressure. It is not recommended for people with severe liver problems or during pregnancy, which is the period when a woman carries a developing fetus in her womb.
Indications and Purpose
How does Pralsetinib work?
Pralsetinib works by blocking certain proteins in cancer cells that help them grow. Think of it like turning off a switch that powers the cancer cells. This action slows down or stops the growth of the cancer. It's used to treat specific types of cancer with certain genetic mutations.
Is Pralsetinib effective?
Pralsetinib is effective for treating certain types of cancer, such as non-small cell lung cancer with specific genetic mutations. Clinical studies show it can shrink tumors and improve survival rates. Your doctor will monitor your progress with regular check-ups and tests to ensure the medication is working effectively for your condition.
What is Pralsetinib?
Pralsetinib is a medication used to treat certain types of cancer, such as non-small cell lung cancer with specific genetic mutations. It works by blocking proteins that help cancer cells grow. This medication is part of a class called kinase inhibitors, which target specific enzymes in cancer cells to slow their growth.
Directions for Use
For how long do I take Pralsetinib?
Pralsetinib is usually a long-term medication for managing certain cancers. You'll typically take it every day as part of your treatment plan unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your treatment.
How do I dispose of Pralsetinib?
Bring unused Pralsetinib to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away.
How do I take Pralsetinib?
Pralsetinib is usually taken once daily. You should take it on an empty stomach, at least 1 hour before or 2 hours after a meal. Swallow the tablet whole with water; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose. Do not take two doses at once. Always follow your doctor's specific instructions.
How long does it take for Pralsetinib to start working?
Pralsetinib begins working in your body shortly after you take it, but the full therapeutic effects may take weeks to become noticeable. The time it takes to work can depend on your specific condition and overall health. Regular check-ups with your doctor will help monitor your progress and adjust your treatment as needed.
How should I store Pralsetinib?
Store Pralsetinib at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. Always keep Pralsetinib out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Pralsetinib?
The usual starting dose of Pralsetinib for adults is 400 mg once daily. Your doctor may adjust your dose based on your response to the medication and any side effects you experience. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can I take Pralsetinib with other prescription drugs?
Pralsetinib can interact with certain medications, increasing the risk of side effects or reducing effectiveness. It's important to tell your doctor about all the medications you're taking, including over-the-counter drugs and supplements. Your doctor can help manage any potential interactions and adjust your treatment plan as needed.
Can Pralsetinib be taken safely while breastfeeding?
Pralsetinib is not recommended while breastfeeding. We don't have much information about whether it passes into human breast milk. If you're taking Pralsetinib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Pralsetinib be taken safely while pregnant?
Pralsetinib is not recommended during pregnancy. It can harm an unborn baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options. Your doctor can help create a pregnancy-specific treatment plan that protects both you and your baby.
Does Pralsetinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Pralsetinib include fatigue, constipation, and high blood pressure. Serious side effects can include lung problems and liver damage. If you notice any new or worsening symptoms, contact your doctor immediately. They can help determine if these symptoms are related to Pralsetinib and provide appropriate care.
Does Pralsetinib have any safety warnings?
Yes, Pralsetinib has important safety warnings. It can cause serious lung problems, liver damage, and high blood pressure. If you experience symptoms like difficulty breathing, yellowing of the skin or eyes, or severe headaches, seek medical help immediately. Not adhering to these warnings can lead to severe health issues. Always follow your doctor's advice and report any new symptoms.
Is it safe to drink alcohol while taking Pralsetinib?
It's best to avoid alcohol while taking Pralsetinib. Alcohol can increase the risk of liver damage and worsen side effects like dizziness. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like nausea or trouble breathing. Talk with your doctor about alcohol use while taking Pralsetinib.
Is it safe to exercise while taking Pralsetinib?
You can exercise while taking Pralsetinib, but be cautious. This medication can cause fatigue and dizziness, which might affect your exercise capacity. To exercise safely, drink plenty of water and watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest.
Is it safe to stop Pralsetinib?
Stopping Pralsetinib suddenly can cause your condition to worsen. It's used for long-term treatment of certain cancers. Always talk with your doctor before stopping Pralsetinib. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely.
Is Pralsetinib addictive?
Pralsetinib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Pralsetinib doesn't carry this risk.
Is Pralsetinib safe for the elderly?
Elderly patients may be more vulnerable to side effects of Pralsetinib, such as high blood pressure and liver problems. It's important for older adults to have regular check-ups to monitor for these issues. Your doctor will assess the risks and benefits before prescribing Pralsetinib to elderly patients.
What are the most common side effects of Pralsetinib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Pralsetinib include fatigue, constipation, and high blood pressure. These effects vary from person to person. If you notice new symptoms after starting Pralsetinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Pralsetinib?
Don't take Pralsetinib if you're allergic to it or its ingredients. It's not recommended for people with severe liver problems. Caution is needed if you have high blood pressure or lung issues. Always consult your doctor about these concerns. They will weigh the benefits and risks before prescribing Pralsetinib.
