Plecanatide
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Guanylate Cyclase-C Agonist
Controlled Drug Substance
NO
Plecanatide
Summary
Plecanatide is used to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBSC). These conditions involve difficulty in bowel movement and related discomfort.
Plecanatide works by mimicking a natural substance in your intestines. It increases fluid secretion in the intestines, making your bowel movements easier and relieving constipation.
The typical dose for adults is 3 mg once daily. You can take Plecanatide with or without food. You can swallow the tablet whole or dissolve it in water if you have difficulty swallowing.
The most common side effects of Plecanatide are diarrhea, nausea, gas, and abdominal discomfort. Severe dehydration is a rare but serious risk. If you experience these side effects, you should consult your doctor.
Plecanatide is not approved for use in children under 6 years of age due to risks of severe dehydration. It should not be used by people with known or suspected bowel blockages. Always consult your doctor before using Plecanatide if you are pregnant, breastfeeding, or taking other medications.
Indications and Purpose
How does Plecanatide work?
Plecanatide mimics a natural intestinal peptide that activates receptors to increase fluid secretion in the intestine, promoting easier and regular bowel movements.
Is Plecanatide effective?
Yes, Plecanatide has shown effectiveness in increasing bowel movement frequency and reducing abdominal discomfort in patients with CIC or IBS-C based on clinical studies.
What is Plecanatide?
Plecanatide is a medication used to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults. It works by increasing fluid secretion in the intestines, making bowel movements easier and relieving constipation.
Directions for Use
For how long do I take Plecanatide?
Plecanatide can be used long-term if prescribed for managing chronic constipation conditions. Continue as advised by your doctor to maintain symptom relief.
How do I take Plecanatide?
Take Plecanatide once daily with or without food. Swallow the tablet whole or dissolve it in water if swallowing is difficult. Follow your doctor’s instructions carefully.
How long does it take for Plecanatide to start working?
Most people notice improvements within a few days of starting treatment, though response times can vary.
How should I store Plecanatide?
Store at room temperature in a dry place. Keep the medication tightly closed in its original packaging to protect it from moisture.
What is the usual dose of Plecanatide?
The typical dose for adults is 3 mg once daily. This medication is not approved for use in children under 6 years of age due to risks of severe dehydration.
Warnings and Precautions
Can I take Plecanatide with other prescription drugs?
Plecanatide is generally safe to combine with most drugs. However, discuss any other medications with your doctor to rule out potential interactions.
Can Plecanatide be taken safely while breastfeeding?
There is limited information on the safety of Plecanatide during breastfeeding. Consult your doctor before using the medication if breastfeeding.
Can Plecanatide be taken safely while pregnant?
The safety of Plecanatide during pregnancy is not well established. Consult your doctor to evaluate the risks and benefits in your case.
Is it safe to drink alcohol while taking Plecanatide?
Moderate alcohol consumption is usually safe but avoid excessive drinking as it may worsen dehydration. Always consult your doctor for personalized advice.
Is it safe to exercise while taking Plecanatide?
Exercise is safe while taking Plecanatide. Avoid intense activity if you experience dehydration due to diarrhea, and drink plenty of fluids to stay hydrated.
Is Plecanatide safe for the elderly?
Plecanatide is generally safe for elderly patients, though they may be more susceptible to dehydration caused by diarrhea. Monitoring is recommended.
Who should avoid taking Plecanatide?
It should not be used by children under 6 or people with known or suspected bowel blockages. Consult your doctor if you have other medical conditions.
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