Pitolisant
Sleep Wake Disorders
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Histamine-3 Receptor Antagonist/Inverse Agonist
Controlled Drug Substance
No
pitolisant
Summary
Pitolisant is used to treat excessive daytime sleepiness in adults with narcolepsy, which is a sleep disorder causing overwhelming daytime drowsiness.
Pitolisant works by blocking histamine H3 receptors in the brain, which increases the release of histamine, a chemical that promotes wakefulness.
The usual starting dose of Pitolisant for adults is 8.9 mg once daily in the morning. The maximum recommended dose is 35.6 mg daily. Always follow your doctor's specific dosing instructions.
Common side effects of Pitolisant include insomnia, which is trouble sleeping, nausea, which is feeling sick to your stomach, and anxiety, which is feeling worried or nervous.
Pitolisant may cause QT prolongation, which is a heart rhythm condition. It is contraindicated in people with severe liver impairment. Always inform your doctor about all medications you take.
Indications and Purpose
How does Pitolisant work?
Pitolisant works by blocking histamine H3 receptors in the brain, which increases the release of histamine, a chemical that promotes wakefulness. Think of it like turning up the volume on a radio to hear better. This action helps improve alertness and reduce excessive daytime sleepiness in people with narcolepsy.
Is Pitolisant effective?
Pitolisant is effective for treating excessive daytime sleepiness in adults with narcolepsy, which is a sleep disorder causing overwhelming daytime drowsiness. Clinical studies show Pitolisant improves wakefulness and reduces sleep attacks. It works by increasing histamine levels in the brain, which helps promote alertness.
What is Pitolisant?
Pitolisant is a medication used to treat excessive daytime sleepiness in adults with narcolepsy, which is a sleep disorder causing overwhelming daytime drowsiness. It works by increasing histamine levels in the brain, which helps promote wakefulness. Pitolisant is part of a class of medications called histamine H3 receptor antagonists.
Directions for Use
For how long do I take Pitolisant?
Pitolisant is usually a long-term medication for managing narcolepsy, which is a chronic condition. You'll typically take Pitolisant every day as a lifelong treatment unless your doctor suggests otherwise. Always talk with your doctor before changing or stopping your Pitolisant treatment.
How do I dispose of Pitolisant?
Bring unused Pitolisant to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. Mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Pitolisant?
Take Pitolisant as directed by your doctor, usually once daily in the morning. You can take it with or without food. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for Pitolisant to start working?
Pitolisant begins working in your body shortly after you take it, but you may not notice all the benefits right away. Some people feel more awake within a few days, but it may take several weeks to experience the full effects. How quickly it works can depend on your overall health and response to the medication.
How should I store Pitolisant?
Store Pitolisant at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. Always store Pitolisant out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Pitolisant?
The usual starting dose of Pitolisant for adults is 8.9 mg once daily in the morning. Your doctor may adjust your dose based on your response and needs. The maximum recommended dose is 35.6 mg daily. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can I take Pitolisant with other prescription drugs?
Pitolisant can interact with medications that affect heart rhythm, increasing the risk of QT prolongation, which is a heart rhythm condition. It may also interact with strong CYP3A4 inhibitors, which can increase Pitolisant levels in the body. Always inform your doctor about all medications you take to avoid interactions.
Can Pitolisant be taken safely while breastfeeding?
Pitolisant is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. If you're taking Pitolisant and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Pitolisant be taken safely while pregnant?
Pitolisant is not recommended during pregnancy due to limited safety data. Animal studies show potential risks to the developing fetus. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition during this important time.
Does Pitolisant have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Pitolisant include insomnia, nausea, and anxiety. These effects vary in frequency and severity. Serious side effects like heart rhythm changes require immediate medical attention. Always inform your doctor about any new or worsening symptoms while taking Pitolisant.
Does Pitolisant have any safety warnings?
Pitolisant has important safety warnings. It may cause QT prolongation, which is a heart rhythm condition that can lead to serious irregular heartbeats. This risk is higher if you have heart problems or take other medications that affect heart rhythm. Always inform your doctor about all medications you take. If you experience symptoms like dizziness or fainting, seek medical help immediately.
Is it safe to drink alcohol while taking Pitolisant?
It's best to avoid alcohol while taking Pitolisant. Alcohol can increase the risk of side effects like dizziness and drowsiness. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like dizziness or trouble concentrating. Talk with your doctor about alcohol use while taking Pitolisant.
Is it safe to exercise while taking Pitolisant?
You can exercise while taking Pitolisant, but be aware of potential side effects like dizziness or fatigue. These might affect your exercise capacity. To exercise safely, drink plenty of water and watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest.
Is it safe to stop Pitolisant?
Stopping Pitolisant suddenly can cause your symptoms to return or worsen. Always talk with your doctor before stopping Pitolisant. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely.
Is Pitolisant addictive?
Pitolisant is not considered addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. If you have concerns about medication dependence, talk with your doctor. They can provide reassurance and guidance while managing your health condition.
Is Pitolisant safe for the elderly?
Elderly individuals may be more sensitive to the side effects of Pitolisant, such as heart rhythm changes. It's important to monitor for any unusual symptoms. Always consult your doctor about the risks and benefits of using Pitolisant if you are elderly.
What are the most common side effects of Pitolisant?
Side effects are unwanted reactions to a medication. Common side effects of Pitolisant include insomnia, nausea, and anxiety. These effects vary from person to person. If you notice new symptoms after starting Pitolisant, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Pitolisant?
Don't take Pitolisant if you're allergic to it or its ingredients. It is contraindicated in people with severe liver impairment, which affects how the body processes the medication. Caution is needed if you have heart rhythm problems. Always consult your doctor about these concerns.
