Phenindione
NA
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Drug Status
Government Approvals
UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Summary
Phenindione is used to treat and prevent blood clots, which are clumps of blood that can block blood vessels. It is often prescribed for conditions like deep vein thrombosis, which is a clot in a deep vein, and pulmonary embolism, which is a clot in the lungs.
Phenindione works by interfering with the blood's clotting process, which is the way blood thickens to stop bleeding. It reduces the production of vitamin K-dependent clotting factors, which are proteins needed for blood to clot, helping to prevent clots from forming.
Phenindione is usually taken by mouth, which means swallowing it as a pill. The typical starting dose for adults is 200 mg daily, divided into smaller doses. Your doctor may adjust your dose based on blood test results and how you respond to the medication.
Common side effects of phenindione include bleeding and bruising, which are signs of blood leaking from vessels. Serious side effects can include severe bleeding, which requires immediate medical attention. Always inform your doctor about any new or worsening symptoms.
Phenindione can increase the risk of bleeding, which is why regular blood tests are needed. It is not recommended for people with severe liver or kidney problems, or during pregnancy, as it may harm the baby. Always follow your doctor's instructions and report any side effects.
Indications and Purpose
How does phenindione work?
Phenindione works by interfering with the blood's clotting process. It inhibits the production of vitamin K-dependent clotting factors, which are proteins needed for blood to clot. Think of it like turning down the volume on a radio; phenindione reduces the "volume" of clotting activity in your blood, helping to prevent clots from forming.
Is phenindione effective?
Phenindione is effective as an anticoagulant, which means it helps prevent blood clots. It's used to treat and prevent conditions like deep vein thrombosis and pulmonary embolism. Clinical studies support its effectiveness in managing these conditions. Always follow your doctor's instructions to ensure the best outcomes.
What is phenindione?
Phenindione is an anticoagulant, which means it helps prevent blood clots. It works by interfering with the blood's clotting process. Phenindione is used to treat and prevent conditions like deep vein thrombosis and pulmonary embolism. It's often used when other anticoagulants aren't suitable. Always follow your doctor's instructions when taking phenindione.
Directions for Use
For how long do I take phenindione?
Phenindione is usually a long-term medication for managing conditions like atrial fibrillation or after a heart attack. You'll typically take phenindione every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your conditions to worsen. Always talk with your doctor before changing or stopping your phenindione treatment.
How do I dispose of phenindione?
If you can, bring unused phenindione to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take phenindione?
Take phenindione exactly as your doctor prescribes. It's usually taken once or twice daily. You can take it with or without food. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Don't take two doses at once. Always follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for phenindione to start working?
Phenindione begins working in your body shortly after you take it, but it may take a few days to achieve its full therapeutic effect. Your doctor will monitor your blood's clotting time with tests like the INR to ensure the medication is working properly. Always take phenindione exactly as prescribed for the best results.
How should I store phenindione?
Store phenindione at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. Always store phenindione out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of phenindione?
The usual starting dose of phenindione for adults is typically 200 mg daily, divided into smaller doses. Your doctor may adjust your dose based on your blood test results and how you respond to the medication. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can I take phenindione with other prescription drugs?
Phenindione can interact with other medications, increasing the risk of bleeding. Drugs like aspirin, NSAIDs, and other anticoagulants can enhance this risk. Always inform your doctor about all medications you're taking to avoid harmful interactions. Your doctor can adjust your treatment plan to ensure safety.
Can phenindione be taken safely while breastfeeding?
Phenindione is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. If you're taking phenindione and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can phenindione be taken safely while pregnant?
Phenindione isn't recommended during pregnancy due to the risk of harm to the baby. It can cause bleeding complications. If you're pregnant or planning to become pregnant, talk with your doctor about safer alternatives to manage your condition during this important time.
Does phenindione have adverse effects?
Adverse effects are unwanted reactions to a medication. With phenindione, common adverse effects include bleeding and bruising. Serious side effects can include severe bleeding, which requires immediate medical attention. Always tell your doctor about any new or worsening symptoms while taking phenindione.
Does phenindione have any safety warnings?
Phenindione has important safety warnings. It can increase your risk of bleeding, which is why regular blood tests are needed to monitor its effects. Not adhering to safety warnings can lead to serious bleeding complications. If you experience unusual bleeding or bruising, contact your doctor immediately. Always follow your doctor's instructions and report any side effects.
Is it safe to drink alcohol while taking phenindione?
It's best to avoid alcohol while taking phenindione. Alcohol can increase your risk of bleeding, which is a serious side effect of phenindione. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like unusual bruising or bleeding. Talk with your doctor about alcohol use while taking phenindione to get personalized advice.
Is it safe to exercise while taking phenindione?
You can exercise while taking phenindione, but be cautious. This medication increases your risk of bleeding, so avoid activities that could cause injury. To exercise safely, choose low-impact activities and wear protective gear if needed. If you notice unusual bruising or bleeding, stop exercising and talk with your doctor.
Is it safe to stop phenindione?
Stopping phenindione suddenly can increase your risk of blood clots. If you're taking it for a condition like atrial fibrillation or after a heart attack, stopping could worsen your condition. Always talk with your doctor before stopping phenindione. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control.
Is phenindione addictive?
Phenindione is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. It works by affecting your blood's ability to clot, not by affecting brain chemistry. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is phenindione safe for the elderly?
Elderly individuals are more vulnerable to the safety risks of phenindione, such as bleeding. It's important for older adults to have regular blood tests to monitor the medication's effects. Your doctor will adjust your dose as needed to minimize risks. Always follow your doctor's instructions and report any side effects.
What are the most common side effects of phenindione?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of phenindione include bleeding and bruising. If you notice new symptoms after starting phenindione, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking phenindione?
Don't take phenindione if you're allergic to it or have a history of bleeding disorders. It's not for people with severe liver or kidney problems. Avoid this medication during pregnancy, as it may harm your baby. Always consult your doctor about these concerns.
