Pemigatinib
Cholangiocarcinoma
.svg)
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
pemigatinib
Summary
Pemigatinib is used to treat cholangiocarcinoma, which is a cancer of the bile ducts. It is effective when the cancer has a specific genetic mutation, helping to slow or stop the growth of cancer cells.
Pemigatinib works by blocking specific proteins in cancer cells, known as kinases, which are involved in cell growth and division. This action helps slow or stop the growth of cancer cells.
The usual starting dose of Pemigatinib for adults is 13.5 mg once daily. It is taken orally, which means by mouth, and can be taken with or without food.
Common side effects of Pemigatinib include high phosphate levels, diarrhea, and low blood counts. Fatigue and gastrointestinal issues like nausea and vomiting may also occur.
Pemigatinib can cause serious eye problems and high phosphate levels. It is not recommended for those with severe kidney or liver problems, or during pregnancy and breastfeeding. Regular monitoring by a doctor is essential.
Indications and Purpose
How does Pemigatinib work?
Pemigatinib works by blocking specific proteins in cancer cells, known as kinases, which are involved in cell growth and division. By inhibiting these proteins, Pemigatinib helps slow or stop the growth of cancer cells. Think of it like turning off a switch that allows cancer cells to multiply. This action makes Pemigatinib effective in treating certain cancers with specific genetic mutations.
Is Pemigatinib effective?
Pemigatinib is effective for treating certain types of cancer, such as cholangiocarcinoma, which is a cancer of the bile ducts. It works by targeting specific proteins in cancer cells, helping to slow or stop their growth. Clinical studies have shown positive outcomes in patients using Pemigatinib, supporting its effectiveness for its approved indications.
What is Pemigatinib?
Pemigatinib is a medication used to treat certain types of cancer, such as cholangiocarcinoma, which is a cancer of the bile ducts. It belongs to a class of drugs called kinase inhibitors, which work by blocking specific proteins in cancer cells, helping to slow or stop their growth. Pemigatinib is used when the cancer has a specific genetic mutation and is usually part of a comprehensive treatment plan.
Directions for Use
For how long do I take Pemigatinib?
Pemigatinib is usually a long-term medication for managing certain cancers. The duration of use depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Pemigatinib treatment. They will guide you on the best course of action for your condition.
How do I dispose of Pemigatinib?
Dispose of unused Pemigatinib by taking it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Pemigatinib?
Take Pemigatinib as prescribed by your doctor, usually once daily. You can take it with or without food. Do not crush or chew the tablets. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Follow any dietary or beverage restrictions your doctor advises.
How long does it take for Pemigatinib to start working?
Pemigatinib begins working in your body shortly after you take it, but the full therapeutic effects may take weeks to months to become apparent. The time it takes to work can depend on your specific condition, overall health, and how your body responds to the treatment. Regular check-ups with your doctor are important to monitor your progress.
How should I store Pemigatinib?
Store Pemigatinib at room temperature, away from moisture and light. Keep it in its original container, tightly closed, and out of reach of children. Do not store it in humid places like bathrooms. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Pemigatinib?
The usual starting dose of Pemigatinib for adults is 13.5 mg once daily. Your doctor may adjust your dose based on your response and any side effects. Always follow your doctor's specific dosing instructions for your personal health needs. There are no established dosing instructions for children or the elderly, so consult your doctor for guidance.
Warnings and Precautions
Can I take Pemigatinib with other prescription drugs?
Pemigatinib can interact with other medications, increasing the risk of side effects or reducing its effectiveness. It's important to inform your doctor about all the medications you're taking, including over-the-counter drugs and supplements. Your doctor can help manage any potential interactions and adjust your treatment plan as needed.
Can Pemigatinib be taken safely while breastfeeding?
Pemigatinib is not recommended while breastfeeding. There is limited information on whether it passes into human breast milk, but it could pose risks to a nursing infant. If you're taking Pemigatinib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Pemigatinib be taken safely while pregnant?
Pemigatinib is not recommended during pregnancy due to potential risks to the unborn baby. There is limited information on its safety in pregnant women, but animal studies suggest possible harm. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for your condition.
Does Pemigatinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Pemigatinib include high phosphate levels, diarrhea, and low blood counts. Serious side effects can include eye problems and liver issues. If you notice any new or worsening symptoms, contact your doctor immediately. They can help determine if these symptoms are related to Pemigatinib and suggest appropriate actions.
Does Pemigatinib have any safety warnings?
Yes, Pemigatinib has important safety warnings. It can cause serious eye problems, so regular eye exams are recommended. It may also cause high phosphate levels in your blood, which can lead to complications. Not adhering to these warnings can result in severe health issues. Always follow your doctor's advice and report any unusual symptoms immediately.
Is it safe to drink alcohol while taking Pemigatinib?
It's best to avoid alcohol while taking Pemigatinib. Alcohol can interfere with the medication's effectiveness and increase the risk of side effects like dehydration. If you choose to drink occasionally, limit your alcohol intake and watch for any unusual symptoms. Talk with your doctor about alcohol use while taking Pemigatinib for personalized advice.
Is it safe to exercise while taking Pemigatinib?
You can exercise while taking Pemigatinib, but be mindful of your body's response. This medication can cause fatigue, which might affect your exercise capacity. To exercise safely, listen to your body and avoid overexertion. If you feel unusually tired or experience any concerning symptoms, slow down or stop exercising and rest.
Is it safe to stop Pemigatinib?
Stopping Pemigatinib suddenly can affect your treatment outcome. It's used for long-term management of certain cancers, and stopping it without medical advice could worsen your condition. Always talk with your doctor before stopping Pemigatinib. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control.
Is Pemigatinib addictive?
Pemigatinib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. It works by targeting specific proteins in cancer cells and doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Pemigatinib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Pemigatinib, such as dehydration and low blood counts. It's important for older adults to be closely monitored by their healthcare provider while taking this medication. Regular check-ups can help manage any potential risks and ensure the treatment remains safe and effective.
What are the most common side effects of Pemigatinib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Pemigatinib include high phosphate levels, diarrhea, and low blood counts. These effects vary from person to person. If you notice new symptoms after starting Pemigatinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Pemigatinib?
Pemigatinib should not be used if you are allergic to it or any of its ingredients. Serious allergic reactions require immediate medical help. It's also contraindicated in patients with severe kidney or liver problems. Always consult your doctor about any concerns and provide a full medical history to ensure Pemigatinib is safe for you.
