Pazopanib
Renal Cell Carcinoma, Soft Tissue Neoplasms
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Possible
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
pazopanib
Summary
Pazopanib is used to treat certain types of cancer, such as advanced kidney cancer and soft tissue sarcoma, which is a type of cancer that begins in the tissues that connect, support, or surround other structures and organs of the body.
Pazopanib works by blocking proteins called tyrosine kinases, which help cancer cells grow and spread. By inhibiting these proteins, it slows down tumor growth and progression, helping to manage the cancer effectively.
The usual starting dose of Pazopanib for adults is 800 mg taken once daily. It should be taken on an empty stomach, which means at least one hour before or two hours after a meal, and the tablet should be swallowed whole with water.
Common side effects of Pazopanib include fatigue, which is feeling very tired, nausea, which is feeling sick to your stomach, diarrhea, which is frequent loose or watery stools, and changes in hair color. These effects are usually mild to moderate.
Pazopanib can cause liver problems, so regular liver function tests are needed. It may also increase blood pressure, so monitoring is important. It is not recommended for people with severe liver issues or during pregnancy due to potential harm to the unborn baby.
Indications and Purpose
How does Pazopanib work?
Pazopanib works by inhibiting tyrosine kinases, which are proteins that help cancer cells grow and spread. By blocking these proteins, Pazopanib slows tumor growth and progression. Think of it like turning off a switch that powers cancer cell growth. This helps manage certain cancers effectively.
Is Pazopanib effective?
Pazopanib is effective in treating certain types of cancer, such as kidney cancer and soft tissue sarcoma. It works by inhibiting proteins that promote tumor growth. Clinical studies show it can slow disease progression and improve survival rates. Your doctor will monitor your response to ensure the treatment is working.
What is Pazopanib?
Pazopanib is a medication used to treat certain types of cancer, such as kidney cancer and soft tissue sarcoma. It belongs to a class of drugs called tyrosine kinase inhibitors, which work by blocking proteins that promote tumor growth. This helps slow the progression of cancer and manage symptoms.
Directions for Use
For how long do I take Pazopanib?
Pazopanib is usually taken long-term for managing certain cancers. The duration depends on your response to treatment and any side effects. Your doctor will guide you on how long to continue taking Pazopanib. Always follow your doctor's advice and don't stop the medication without consulting them.
How do I dispose of Pazopanib?
Dispose of Pazopanib through a drug take-back program or collection site at a pharmacy or hospital. If unavailable, mix the medication with an undesirable substance like used coffee grounds, seal it in a plastic bag, and throw it away. This prevents harm to people and the environment.
How do I take Pazopanib?
Take Pazopanib on an empty stomach, at least one hour before or two hours after a meal. Swallow the tablet whole with water, without crushing or chewing it. It's usually taken once daily. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose. Avoid grapefruit and grapefruit juice while taking Pazopanib, as they can interfere with the medication.
How long does it take for Pazopanib to start working?
Pazopanib starts working in your body shortly after you take it, but noticeable effects may take weeks. The full therapeutic effect can vary based on individual factors like cancer type and overall health. Regular monitoring by your doctor will help assess how well the medication is working for you.
How should I store Pazopanib?
Store Pazopanib at room temperature, away from moisture and light. Keep it in its original container, tightly closed. Avoid storing it in humid places like bathrooms. No refrigeration is needed. Always keep it out of reach of children and check the expiration date regularly.
What is the usual dose of Pazopanib?
The usual starting dose of Pazopanib for adults is 800 mg once daily. It should be taken on an empty stomach. Your doctor may adjust the dose based on your response and any side effects. Always follow your doctor's specific dosing instructions. Special populations, like those with liver issues, may require dose adjustments.
Warnings and Precautions
Can I take Pazopanib with other prescription drugs?
Pazopanib can interact with certain medications, increasing the risk of side effects or reducing effectiveness. Avoid strong CYP3A4 inhibitors like ketoconazole, which can increase Pazopanib levels. Blood thinners like warfarin may increase bleeding risk. Always inform your doctor about all medications you're taking to manage interactions safely.
Can Pazopanib be taken safely while breastfeeding?
Pazopanib is not recommended while breastfeeding. It's unclear if it passes into human breast milk, but it could pose risks to a nursing infant. If you're taking Pazopanib and wish to breastfeed, talk with your doctor about safer alternatives to protect your baby's health.
Can Pazopanib be taken safely while pregnant?
Pazopanib is not recommended during pregnancy due to potential harm to the unborn baby. Limited human data is available, but animal studies suggest risks. If you're pregnant or planning to become pregnant, discuss alternative treatments with your doctor to ensure safety for you and your baby.
Does Pazopanib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Pazopanib include diarrhea, high blood pressure, and changes in hair color. Serious effects can include liver problems and heart issues. If you notice any new or worsening symptoms, contact your doctor immediately. Regular monitoring helps manage these effects.
Does Pazopanib have any safety warnings?
Yes, Pazopanib has important safety warnings. It can cause liver problems, so regular liver function tests are needed. It may also increase blood pressure, so monitoring is important. Serious bleeding and heart problems can occur. Not following these warnings can lead to severe health issues. Always adhere to your doctor's advice and report any unusual symptoms immediately.
Is it safe to drink alcohol while taking Pazopanib?
It's best to avoid alcohol while taking Pazopanib. Alcohol can increase the risk of liver damage, which is a concern with this medication. If you choose to drink, limit your intake and discuss it with your doctor to ensure it doesn't interfere with your treatment.
Is it safe to exercise while taking Pazopanib?
You can exercise while taking Pazopanib, but be cautious. This medication can cause fatigue and high blood pressure, which might affect your exercise capacity. Stay hydrated and avoid strenuous activities if you feel unwell. Consult your doctor for personalized advice on exercising safely.
Is it safe to stop Pazopanib?
Stopping Pazopanib suddenly can affect your treatment. It's used for long-term management of certain cancers. Stopping without medical advice can lead to disease progression. Always talk with your doctor before stopping Pazopanib. They can guide you on how to safely discontinue or adjust your treatment.
Is Pazopanib addictive?
Pazopanib is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. This medication works by targeting cancer cells and doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Pazopanib safe for the elderly?
Elderly patients may be more vulnerable to side effects of Pazopanib, such as liver problems and high blood pressure. Close monitoring is important to manage these risks. Your doctor will assess the benefits and risks before prescribing Pazopanib to ensure it's safe for you.
What are the most common side effects of Pazopanib?
Side effects are unwanted reactions to a medication. Common side effects of Pazopanib include diarrhea, nausea, and changes in hair color. These effects vary among individuals. If you experience new symptoms, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication.
Who should avoid taking Pazopanib?
Don't take Pazopanib if you're allergic to it or its ingredients. It's contraindicated in people with severe liver problems. Caution is needed if you have heart issues or are taking certain medications. Always consult your doctor about your medical history before starting Pazopanib.
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