Palbociclib
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Palbociclib
Summary
Palbociclib is used to treat certain types of breast cancer, particularly hormone receptor-positive, HER2-negative advanced or metastatic breast cancer, which refers to cancer that has spread beyond the breast to other parts of the body.
Palbociclib works by inhibiting proteins called CDK4 and CDK6, which help cancer cells grow and divide. By blocking these proteins, it slows down the growth of cancer cells, helping to control the progression of the disease.
The usual starting dose of Palbociclib for adults is 125 mg once daily for 21 days, followed by 7 days off. This cycle repeats every 28 days. It should be taken with food, and the capsule should be swallowed whole.
Common side effects of Palbociclib include low blood cell counts, which can increase infection risk, fatigue, which means feeling very tired, and nausea, which is feeling sick to your stomach.
Palbociclib can lower blood cell counts, increasing infection risk, and cause lung problems. It is not recommended for people with severe liver problems or during pregnancy. Avoid grapefruit, which can increase the medication's effects.
Indications and Purpose
How does Palbociclib work?
Palbociclib works by inhibiting proteins called CDK4 and CDK6, which help cancer cells grow and divide. By blocking these proteins, Palbociclib slows down the growth of cancer cells. Think of it like putting a brake on a car to slow it down. This action helps control the progression of certain types of breast cancer. Palbociclib is often used with other treatments to enhance its effectiveness.
Is Palbociclib effective?
Palbociclib is effective in treating certain types of breast cancer. It works by inhibiting proteins that help cancer cells grow. Clinical studies show Palbociclib, when combined with other cancer treatments, can slow disease progression and improve survival rates. These results support its effectiveness in managing breast cancer. Your doctor will monitor your response to ensure the medication is working as intended.
What is Palbociclib?
Palbociclib is a medication used to treat certain types of breast cancer. It belongs to a class of drugs called CDK4/6 inhibitors, which work by blocking proteins that help cancer cells grow. Palbociclib is usually used in combination with other cancer treatments to improve effectiveness. It helps slow the progression of cancer and can improve survival rates in patients with advanced breast cancer.
Directions for Use
For how long do I take Palbociclib?
Palbociclib is usually a long-term medication for managing breast cancer. You'll typically take it as part of a treatment cycle, with 21 days on the medication followed by 7 days off. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Palbociclib treatment.
How do I dispose of Palbociclib?
Dispose of unused Palbociclib through a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away.
How do I take Palbociclib?
Take Palbociclib once daily with food, preferably at the same time each day. Swallow the capsule whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Avoid grapefruit and grapefruit juice while taking Palbociclib, as they can increase the medication's effects.
How long does it take for Palbociclib to start working?
Palbociclib starts working in your body shortly after you take it, but you may not notice all the benefits right away. It can take several weeks to see significant changes in your cancer's progression. Your doctor will monitor your progress through regular check-ups and imaging tests. How quickly Palbociclib works can depend on your overall health and response to treatment. Take it exactly as prescribed for the best results.
How should I store Palbociclib?
Store Palbociclib at room temperature, away from moisture and light. Keep it in its original container, tightly closed. Don't store it in humid places like bathrooms, as moisture can affect the medication. Always keep Palbociclib out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Palbociclib?
The usual starting dose of Palbociclib for adults is 125 mg once daily for 21 days, followed by 7 days off. This cycle repeats every 28 days. Your doctor may adjust the dose based on your response and any side effects. There are no specific dosing instructions for children or the elderly, but dose adjustments may be necessary for those with liver problems. Always follow your doctor's specific dosing instructions.
Warnings and Precautions
Can I take Palbociclib with other prescription drugs?
Palbociclib can interact with certain medications, increasing the risk of side effects or reducing effectiveness. Strong CYP3A inhibitors, like ketoconazole, can increase Palbociclib levels, while inducers like rifampin can decrease its effectiveness. Always inform your doctor about all medications you take to prevent interactions. Your doctor can adjust your treatment plan to ensure safety and effectiveness.
Can Palbociclib be taken safely while breastfeeding?
Palbociclib is not recommended while breastfeeding. We don't have much information about whether it passes into human breast milk. However, it may pose risks to a breastfed baby. If you're taking Palbociclib and want to breastfeed, talk with your doctor about safer medication options. They can help you find a treatment that allows you to nurse your baby safely.
Can Palbociclib be taken safely while pregnant?
Palbociclib is not recommended during pregnancy. It can harm an unborn baby. We don't have much information about its use in pregnant women, but animal studies show potential risks. If you're pregnant or planning to become pregnant, talk with your doctor about safer treatment options. They can help create a plan that protects both you and your baby.
Does Palbociclib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Palbociclib include low blood cell counts, fatigue, and nausea. Serious effects can include infections and lung problems. If you notice new or worsening symptoms, contact your doctor. They can help determine if these are related to Palbociclib and suggest appropriate actions. Regular monitoring helps manage adverse effects effectively.
Does Palbociclib have any safety warnings?
Yes, Palbociclib has important safety warnings. It can lower blood cell counts, increasing infection risk. Regular blood tests are needed to monitor this. If you experience fever, chills, or signs of infection, contact your doctor immediately. Palbociclib can also cause lung problems, so report any new or worsening cough or breathing issues. Adhering to these warnings helps prevent serious complications.
Is it safe to drink alcohol while taking Palbociclib?
It's best to avoid alcohol while taking Palbociclib. Alcohol can increase the risk of liver problems, which Palbociclib can also cause. Drinking alcohol may worsen side effects like nausea or dizziness. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like unusual fatigue or stomach pain. Talk with your doctor about alcohol use while taking Palbociclib for personalized advice.
Is it safe to exercise while taking Palbociclib?
You can exercise while taking Palbociclib, but keep a few things in mind. This medication can cause fatigue, which might affect your exercise capacity. Listen to your body and avoid strenuous activities if you feel tired. Stay hydrated and watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest. Talk with your doctor if you have concerns about your specific situation.
Is it safe to stop Palbociclib?
Stopping Palbociclib suddenly can affect your cancer treatment. It's usually used long-term for chronic conditions like breast cancer. Stopping without medical advice could worsen your condition. Always talk with your doctor before stopping Palbociclib. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely.
Is Palbociclib addictive?
Palbociclib is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Palbociclib works by inhibiting certain proteins in cancer cells, which doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, Palbociclib doesn't carry this risk.
Is Palbociclib safe for the elderly?
Elderly patients may be more vulnerable to side effects of Palbociclib, such as low blood cell counts and infections. Regular monitoring is important to manage these risks. Palbociclib is generally safe for elderly patients when used under a doctor's supervision. Your doctor will consider your overall health and any other medications you take to ensure Palbociclib is safe for you.
What are the most common side effects of Palbociclib?
Side effects are unwanted reactions to a medication. Common side effects of Palbociclib include low blood cell counts, fatigue, and nausea. These effects vary from person to person. If you notice new symptoms after starting Palbociclib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication. They can help determine if the side effects are related to Palbociclib.
Who should avoid taking Palbociclib?
Don't take Palbociclib if you're allergic to it or its ingredients. It's not recommended for people with severe liver problems, as it can worsen liver function. Use caution if you have a history of lung problems, as Palbociclib can cause lung issues. Always consult your doctor about these concerns. They can help determine if Palbociclib is safe for you based on your health history.
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