Oxaprozin
Juvenile Arthritis, Rheumatoid Arthritis ... show more
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Nonsteroidal Anti-inflammatory Drug
Controlled Drug Substance
No
Oxaprozin
Summary
Oxaprozin is used to relieve symptoms associated with osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. It helps reduce pain, swelling, and stiffness in the joints, improving mobility and quality of life for those affected by these conditions.
Oxaprozin works by inhibiting enzymes called COX-1 and COX-2, which are involved in the production of chemicals called prostaglandins that cause inflammation, pain, and fever. By reducing the production of these chemicals, Oxaprozin helps alleviate these symptoms.
For adults, the usual dose of Oxaprozin is 1200 mg taken once daily. For children aged 6 to 16 years with juvenile rheumatoid arthritis, the dose is based on body weight: 600 mg for 22-31 kg, 900 mg for 32-54 kg, and 1200 mg for those 55 kg or more.
Common side effects of Oxaprozin include nausea, vomiting, diarrhea, constipation, and headache. Serious adverse effects can include gastrointestinal bleeding, heart attack, stroke, and liver or kidney damage.
Oxaprozin carries an increased risk of heart attack or stroke, especially with long-term use, and gastrointestinal issues like bleeding or ulcers. It should not be used by patients with a history of allergic reactions to NSAIDs, recent heart surgery, or severe liver or kidney disease.
Indications and Purpose
How does Oxaprozin work?
Oxaprozin works by inhibiting the enzymes COX-1 and COX-2, which are involved in the production of prostaglandins. Prostaglandins are chemicals that promote inflammation, pain, and fever. By reducing their production, Oxaprozin helps alleviate these symptoms.
Is Oxaprozin effective?
Oxaprozin is proven effective in relieving pain, tenderness, swelling, and stiffness associated with osteoarthritis and rheumatoid arthritis. Clinical trials have shown it to be comparable to other NSAIDs in managing these symptoms, providing significant relief for many patients.
What is Oxaprozin?
Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and stiffness from arthritis. It works by blocking the production of substances in the body that cause inflammation and pain. This helps improve joint function and mobility.
Directions for Use
For how long do I take Oxaprozin?
Oxaprozin is typically used for as long as needed to manage symptoms of arthritis, under the guidance of a healthcare provider. The duration can vary based on individual response and condition severity.
How do I take Oxaprozin?
Oxaprozin should be taken exactly as prescribed by your doctor, usually once daily. It can be taken with or without food, but taking it with food may help reduce stomach upset. There are no specific food restrictions, but avoid alcohol to reduce the risk of stomach bleeding.
How long does it take for Oxaprozin to start working?
Oxaprozin may take several days to reach its full effect, although some pain relief can be noticed within a few hours of taking the first dose. Consistent use as prescribed is important for optimal results.
How should I store Oxaprozin?
Store Oxaprozin in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children and pets. Do not store it in the bathroom to avoid moisture exposure.
What is the usual dose of Oxaprozin?
For adults, the usual dose of Oxaprozin is 1200 mg taken once daily. For children aged 6 to 16 years with juvenile rheumatoid arthritis, the dose is based on body weight: 600 mg for 22-31 kg, 900 mg for 32-54 kg, and 1200 mg for those 55 kg or more.
Warnings and Precautions
Can I take Oxaprozin with other prescription drugs?
Significant drug interactions with Oxaprozin include anticoagulants like warfarin, which increase bleeding risk, and other NSAIDs, which can enhance side effects. It may also interact with ACE inhibitors, diuretics, and lithium, affecting their efficacy or increasing side effects.
Can Oxaprozin be taken safely while breastfeeding?
There is limited information on the safety of Oxaprozin during breastfeeding. It's best to consult your doctor to weigh the benefits and risks before using this medication while nursing.
Can Oxaprozin be taken safely while pregnant?
Oxaprozin should be avoided during pregnancy, especially after 20 weeks, due to the risk of fetal harm, such as premature closure of the ductus arteriosus. Consult your doctor for alternative pain management options if you are pregnant or planning to become pregnant.
Is it safe to drink alcohol while taking Oxaprozin?
Drinking alcohol while taking Oxaprozin can increase the risk of stomach bleeding. It's advisable to limit alcohol consumption and discuss with your doctor if you plan to drink alcohol while on this medication.
Is it safe to exercise while taking Oxaprozin?
Oxaprozin does not inherently limit the ability to exercise. However, if you experience side effects like dizziness or fatigue, it may affect your ability to perform physical activities safely. Consult your doctor if you have concerns about exercising while taking Oxaprozin.
Is Oxaprozin safe for the elderly?
Elderly patients should use Oxaprozin with caution due to an increased risk of serious side effects, such as gastrointestinal bleeding and cardiovascular events. It's recommended to start with the lowest effective dose and monitor for adverse effects. Regular check-ups with a healthcare provider are advised.
Who should avoid taking Oxaprozin?
Important warnings for Oxaprozin include an increased risk of heart attack or stroke, especially with long-term use, and gastrointestinal issues like bleeding or ulcers. It's contraindicated in patients with a history of allergic reactions to NSAIDs, recent heart surgery, or severe liver or kidney disease.
