Osimertinib
Non-Small-Cell Lung Carcinoma
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
NO
Osimertinib
Summary
Osimertinib is used to treat nonsmall cell lung cancer, particularly in cases where there are specific mutations in the EGFR gene and other treatments have not been effective.
Osimertinib works by targeting and blocking the EGFR receptor on cancer cells. This receptor is essential for the growth and division of many cancers, including nonsmall cell lung cancer. By blocking this receptor, Osimertinib effectively stops or slows down the progression of the tumor.
The typical adult dose of Osimertinib is 80 mg once a day, taken with or without food. The dosage for children is determined by their body weight and should be administered as directed by a healthcare provider.
Common side effects of Osimertinib include diarrhea, skin rashes, dry skin, and nausea. More serious side effects can include lung problems, heart issues, and liver problems.
Osimertinib should be avoided by individuals who have a history of severe allergic reactions to the drug or its components. It is not recommended for patients with severe liver or lung problems, or certain heart conditions. It is also not recommended during pregnancy or breastfeeding.
Indications and Purpose
How does Osimertinib work?
Osimertinib works by targeting and inhibiting the EGFR receptor on cancer cells. Many cancers, including non-small cell lung cancer, depend on this receptor to grow and divide. By blocking EGFR, osimertinib prevents cancer cells from receiving growth signals, effectively stopping or slowing tumor progression.
Is Osimertinib effective?
Yes, osimertinib is highly effective in patients with EGFR mutations that cause lung cancer. Clinical studies have shown it to significantly reduce tumor growth and improve survival rates compared to older treatments. Its targeted action makes it especially effective in those with drug-resistant mutations that other drugs can't treat.
What is Osimertinib?
Osimertinib is a targeted therapy used to treat non-small cell lung cancer (NSCLC), especially in cases with specific mutations in the EGFR gene. It works by blocking the abnormal EGFR receptor that promotes cancer cell growth. Osimertinib helps control the spread of cancer and is typically used when other treatments are ineffective.
Directions for Use
For how long do I take Osimertinib?
The duration of treatment with osimertinib depends on how well your cancer responds to the drug. Typically, long-term treatment is required for ongoing management of non-small cell lung cancer. Your doctor will monitor progress through scans and tests to determine if you should continue or adjust your treatment.
How do I take Osimertinib?
Take osimertinib once daily, either with or without food. Swallow the tablet whole; do not crush, chew, or break it. If you miss a dose, take it as soon as you remember, but never double the dose. For any questions regarding administration, consult your healthcare provider.
How long does it take for Osimertinib to start working?
Osimertinib can start showing results within weeks. Many patients may notice a decrease in tumor size and symptoms after about 4-8 weeks of treatment. However, the time it takes for the drug to be effective varies, and your doctor will monitor your progress with regular imaging tests.
How should I store Osimertinib?
Store osimertinib at room temperature, between 15°C and 30°C (59°F to 86°F). Keep it in a dry place away from moisture and light. Ensure it is out of reach of children and properly dispose of any expired or unused medication. Do not store the medication in the bathroom.
What is the usual dose of Osimertinib?
The typical adult dose of osimertinib is 80 mg once a day, taken with or without food. Your doctor may adjust the dose based on your response and any side effects. For children, dosage is based on body weight and is determined by your healthcare provider. Always follow your doctor’s instructions for proper use.
Warnings and Precautions
Can I take Osimertinib with other prescription drugs?
Osimertinib may interact with medications that affect liver enzymes, such as antifungals, antibiotics, or anticonvulsants. These drugs may alter osimertinib's absorption and effectiveness. Always disclose all medications you’re taking to your doctor, including over-the-counter drugs, to avoid harmful interactions.
Can Osimertinib be taken safely while breastfeeding?
Osimertinib is not recommended while breastfeeding, as it is not known whether it passes into breast milk and may pose risks to the infant. It is advised to stop breastfeeding during treatment with osimertinib. Consult your doctor for alternatives or further guidance on the best approach for both mother and baby.
Can Osimertinib be taken safely while pregnant?
Osimertinib is not recommended during pregnancy, as it may harm the fetus. It falls under category D, meaning there’s evidence of fetal risk. Women should avoid pregnancy during treatment, and both men and women should use effective birth control during therapy and for some time after stopping the medication.
Is it safe to drink alcohol while taking Osimertinib?
It is generally not recommended to drink alcohol while taking osimertinib. Alcohol can increase the risk of liver toxicity or worsen side effects such as nausea and fatigue. It may also interfere with the effectiveness of your treatment. If you want to drink alcohol, discuss it with your doctor for guidance based on your individual health condition.
Is it safe to exercise while taking Osimertinib?
Exercise is generally safe while taking osimertinib, but moderation is key. If you experience side effects like fatigue, dizziness, or shortness of breath, consider reducing the intensity of your exercise routine. Gentle physical activities like walking or swimming may help you stay active without overexerting yourself. Consult your doctor for personalized advice on exercise during treatment.
Is Osimertinib safe for the elderly?
There is limited information about the safety of osimertinib in the elderly. However, older adults may be more susceptible to side effects such as lung issues or skin reactions. Doctors typically monitor elderly patients closely and may adjust the dosage to minimize risks and ensure the treatment is well-tolerated.
Who should avoid taking Osimertinib?
Osimertinib should be avoided by individuals who have a history of severe allergic reactions to the drug or its components. Patients with severe liver or lung problems or those with certain heart conditions should not take it. Always consult your doctor to ensure it’s the right treatment for you based on your health status.