Orlistat
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Intestinal Lipase Inhibitor
Controlled Drug Substance
NO

Orlistat
Learn more about this medicine -
Click HereSummary
Orlistat is a medication used to help people with overweight or obesity achieve weight loss. It is typically combined with a low-calorie diet and regular physical activity.
Orlistat works by inhibiting an enzyme called lipase, which is responsible for breaking down fats in the digestive tract. This prevents the body from absorbing approximately 30% of the fat consumed.
The usual dose of Orlistat is 120 mg, taken three times a day with each main meal that contains fat. It is typically taken with meals or within 1 hour after a meal.
Common side effects of Orlistat include gastrointestinal issues such as oily stools, flatulence, diarrhea, and abdominal cramping. It may also cause vitamin deficiencies, particularly of fat-soluble vitamins A, D, E, K. Rarely, it may cause liver injury or kidney stones.
Orlistat is not recommended for people with chronic malabsorption syndrome, gallbladder problems, or allergies to Orlistat or any of its ingredients. It's also not recommended for pregnant or breastfeeding women as it may affect nutrient absorption.
Indications and Purpose
How does one know if Orlistat is working?
Orlistat helped people lose weight in studies that lasted up to four years. These studies showed that people taking Orlistat lost more weight than those taking a sugar pill (placebo). It also helped prevent people from gaining the weight back after they'd lost it. Plus, it improved some health problems often linked to being overweight.
How does Orlistat work?
Orlistat works by inhibiting lipase, an enzyme responsible for breaking down fats in the digestive tract. This prevents the body from absorbing approximately 30% of the fat consumed.
Is Orlistat effective?
Orlistat is a medicine that helps people lose weight and keep it off. Studies showed that people taking it lost 3% more weight over two years than those taking a sugar pill (placebo). Also, people on Orlistat regained less weight after they'd already lost some, compared to those on the placebo. Those on the placebo regained a lot more of their lost weight.
What is Orlistat?
Orlistat is a medication used for weight loss. It works by inhibiting the absorption of fats in the digestive system
What is Orlistat used for?
Orlistat is used to help people with overweight or obesity achieve weight loss, particularly when combined with a low-calorie diet and regular physical activity.
Directions for Use
For how long do I take Orlistat?
- Orlistat is usually taken as part of a long-term weight management plan.
- It is typically used for several months or longer, depending on your doctor’s advice and progress.
How do I take Orlistat?
- Take Orlistat with or up to 1 hour after a meal.
- It should be swallowed with water.
- If you miss a dose, skip it and take your next dose at the regular time.
How long does it take for Orlistat to start working?
Orlistat starts working within a few hours of taking it, as it inhibits the digestion and absorption of dietary fat.
How should I store Orlistat?
Keep Orlistat in a cool, dry place between 59°F and 86°F (15°C and 30°C). Make sure the container is closed tightly. Don't use it after the date on the label.
What is the usual dose of Orlistat?
- The usual dose is 120 mg taken three times a day with each main meal that contains fat.
- It is typically taken with meals or within 1 hour after a meal.
Warnings and Precautions
Can I take Orlistat with other prescription drugs?
- Orlistat may interact with medications like blood thinners, antidiabetic drugs, and anticonvulsants.
- Always inform your healthcare provider about other medications you are taking to avoid interactions.
Can I take Orlistat with vitamins or supplements?
- People with chronic malabsorption syndrome (e.g., Crohn’s disease or other intestinal conditions).
- People with gallbladder problems.
- People who are pregnant or breastfeeding.
- People with allergies to Orlistat or any of its ingredients.
Can Orlistat be taken safely while breastfeeding?
Orlistat is not recommended while breastfeeding, as it is not known if it passes into breast milk and may affect the infant’s nutrition.
Can Orlistat be taken safely while pregnant?
Orlistat is not recommended during pregnancy as it may affect the absorption of nutrients important for the developing baby.
Is it safe to drink alcohol while taking Orlistat?
Drinking alcohol in moderation is generally safe while taking Orlistat, but excessive alcohol consumption can affect your weight loss progress.
Is it safe to exercise while taking Orlistat?
Yes, exercise is encouraged while taking Orlistat as part of a healthy weight loss program. Regular physical activity supports overall weight management and health.
Is Orlistat safe for the elderly?
Orlistat can be safe for the elderly but should be used with caution, particularly in those with kidney problems or other health concerns.
Who should avoid taking Orlistat?
- People with chronic malabsorption syndrome (e.g., Crohn’s disease or other intestinal conditions).
- People with gallbladder problems.
- People who are pregnant or breastfeeding.
- People with allergies to Orlistat or any of its ingredients.