Nintedanib
Idiopathic Pulmonary Fibrosis
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Nintedanib
Summary
Nintedanib is used to treat idiopathic pulmonary fibrosis, which is a lung disease causing scarring and breathing difficulties. It is also used for systemic sclerosis-associated interstitial lung disease, which involves lung tissue inflammation and scarring due to systemic sclerosis, a connective tissue disease.
Nintedanib works by inhibiting enzymes called tyrosine kinases, which are involved in the growth and spread of cells. This action helps slow the progression of diseases like idiopathic pulmonary fibrosis by reducing lung scarring, which improves breathing and lung function.
The usual starting dose of Nintedanib for adults is 150 mg taken twice daily with food. The maximum recommended dose is 300 mg per day. It is important to follow your doctor's specific dosing instructions and not to stop taking it without consulting your doctor.
Common side effects of Nintedanib include diarrhea, nausea, and vomiting, which occur in more than 10% of patients. These effects are usually mild to moderate. Taking Nintedanib with food can help reduce stomach upset.
Nintedanib can cause liver problems, so regular liver function tests are needed. It may increase bleeding risk, especially if taken with anticoagulants, which are blood thinners. It is contraindicated in patients with severe liver impairment and those allergic to its ingredients.
Indications and Purpose
How does Nintedanib work?
Nintedanib works by inhibiting enzymes called tyrosine kinases, which are involved in the growth and spread of cells. This action helps slow the progression of diseases like idiopathic pulmonary fibrosis by reducing lung scarring. Think of it like turning down the volume on a radio to reduce noise. This helps improve breathing and lung function.
Is Nintedanib effective?
Nintedanib is effective in treating idiopathic pulmonary fibrosis, which is a lung disease that causes scarring and breathing difficulties. Clinical studies show it slows disease progression by reducing lung function decline. It is also used for other conditions like systemic sclerosis-associated interstitial lung disease. Always follow your doctor's advice to achieve the best outcomes.
What is Nintedanib?
Nintedanib is a medication used to treat idiopathic pulmonary fibrosis, which is a lung disease causing scarring and breathing difficulties. It belongs to a class of drugs called tyrosine kinase inhibitors, which work by blocking certain enzymes involved in disease progression. Nintedanib is also used for other conditions like systemic sclerosis-associated interstitial lung disease.
Directions for Use
For how long do I take Nintedanib?
Nintedanib is usually taken long-term for chronic conditions like idiopathic pulmonary fibrosis. The duration depends on your response and any side effects. Always follow your doctor's advice on how long to take Nintedanib. Do not stop taking it without consulting your doctor, as this could worsen your condition.
How do I dispose of Nintedanib?
Dispose of Nintedanib by taking it to a drug take-back program or collection site at a pharmacy or hospital. If unavailable, mix the medication with an undesirable substance like used coffee grounds, seal it in a plastic bag, and throw it in the trash. This prevents harm to people and the environment.
How do I take Nintedanib?
Take Nintedanib exactly as your doctor prescribes. It's usually taken twice daily, with food, to help reduce stomach upset. Swallow the capsules whole with water; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Avoid taking two doses at once.
How long does it take for Nintedanib to start working?
Nintedanib starts working in your body shortly after you take it, but noticeable benefits may take weeks to months. It slows disease progression in conditions like idiopathic pulmonary fibrosis. How quickly you notice improvements can depend on your overall health and the specific condition being treated. Follow your doctor's instructions for the best results.
How should I store Nintedanib?
Store Nintedanib at room temperature, away from moisture and light. Keep it in its original container, tightly closed. Do not store it in humid places like bathrooms. Always keep it out of reach of children to prevent accidental ingestion. Check expiration dates regularly and dispose of expired medication properly.
What is the usual dose of Nintedanib?
The usual starting dose of Nintedanib for adults is 150 mg taken twice daily with food. Your doctor may adjust the dose based on your response and any side effects. The maximum recommended dose is 300 mg per day. Always follow your doctor's specific dosing instructions for your health needs.
Warnings and Precautions
Can I take Nintedanib with other prescription drugs?
Nintedanib can interact with certain medications, increasing the risk of side effects. For example, it may interact with anticoagulants, which are blood thinners, increasing bleeding risk. Always inform your doctor about all medications you are taking to avoid potential interactions and ensure safe and effective treatment.
Can Nintedanib be taken safely while breastfeeding?
Nintedanib is not recommended while breastfeeding. There is limited information on whether it passes into human breast milk. To avoid potential risks to the baby, discuss with your doctor safer medication options if you wish to breastfeed while managing your condition.
Can Nintedanib be taken safely while pregnant?
Nintedanib is not recommended during pregnancy due to potential risks to the unborn baby. There is limited information on its safety in pregnant women. If you are pregnant or planning to become pregnant, discuss with your doctor the safest treatment options for your condition.
Does Nintedanib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Nintedanib include diarrhea, nausea, and liver enzyme changes. Serious effects can include liver damage and bleeding. If you notice any severe or unusual symptoms, contact your doctor immediately. Regular monitoring and communication with your healthcare provider can help manage any adverse effects.
Does Nintedanib have any safety warnings?
Yes, Nintedanib has important safety warnings. It can cause liver problems, so regular liver function tests are needed. It may also increase the risk of bleeding and cause gastrointestinal issues like diarrhea. If you experience symptoms like yellowing of the skin, severe stomach pain, or unusual bleeding, seek medical help immediately. Always follow your doctor's advice and report any new symptoms.
Is it safe to drink alcohol while taking Nintedanib?
It's best to avoid alcohol while taking Nintedanib. Alcohol can increase the risk of liver damage, which is a concern with Nintedanib. Drinking alcohol may also worsen side effects like nausea. If you choose to drink, limit your intake and discuss with your doctor for personalized advice.
Is it safe to exercise while taking Nintedanib?
You can exercise while taking Nintedanib, but be cautious. This medication can cause side effects like dizziness or fatigue, which might affect your exercise capacity. Listen to your body and avoid strenuous activities if you feel unwell. Stay hydrated and rest if you experience any symptoms during physical activity.
Is it safe to stop Nintedanib?
Stopping Nintedanib suddenly can affect your condition. It's used for long-term management of diseases like idiopathic pulmonary fibrosis. Stopping without medical advice could worsen your condition. Always talk with your doctor before stopping Nintedanib. They may suggest a gradual reduction or an alternative treatment to manage your condition safely.
Is Nintedanib addictive?
Nintedanib is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Nintedanib works by inhibiting certain enzymes involved in disease progression, and this mechanism does not affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, discuss them with your doctor.
Is Nintedanib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Nintedanib, such as liver problems and bleeding. However, it can be used safely with careful monitoring. Regular check-ups and communication with your doctor are important to manage any risks and adjust treatment as needed.
What are the most common side effects of Nintedanib?
Side effects are unwanted reactions to a medication. Common side effects of Nintedanib include diarrhea, nausea, and vomiting. These occur in more than 10% of patients. If you experience new symptoms after starting Nintedanib, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication.
Who should avoid taking Nintedanib?
Nintedanib should not be used if you are allergic to it or its ingredients. It is contraindicated in patients with severe liver impairment. Caution is needed for those with a history of bleeding disorders or who are taking anticoagulants. Always consult your doctor about your medical history before starting Nintedanib.
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