Nevirapine
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
No
Pharmaceutical Class
Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
Controlled Drug Substance
No
Nevirapine
Summary
Nevirapine is used to treat HIV infection, which is a virus that attacks the immune system. It helps control the virus and improve immune function when used with other HIV medications.
Nevirapine works by blocking the reverse transcriptase enzyme, which the HIV virus needs to multiply. This action reduces the amount of virus in the body, helping to improve immune function.
The usual starting dose for adults is 200 mg once daily for the first 14 days, then 200 mg twice daily. It can be taken with or without food, following the doctor's instructions.
Common side effects include rash, fever, and nausea, which are unwanted reactions to the medication. These effects vary among individuals and should be discussed with a doctor if they occur.
Nevirapine can cause severe liver damage and skin reactions, which can be life-threatening. It is contraindicated in people with severe liver problems and those who have had severe allergic reactions to it.
Indications and Purpose
How does Nevirapine work?
Nevirapine works by blocking the reverse transcriptase enzyme, which the HIV virus needs to multiply. Think of it like stopping a copy machine from making more copies. By preventing the virus from multiplying, Nevirapine helps lower the amount of virus in your body, which improves immune function and reduces the risk of HIV-related complications.
Is Nevirapine effective?
Nevirapine is effective in treating HIV infection. It works by blocking the virus from multiplying in your body, which helps lower the amount of virus in your blood. Clinical studies show that Nevirapine, when used with other HIV medications, helps improve immune function and reduce the risk of HIV-related complications.
What is Nevirapine?
Nevirapine is an antiretroviral medication used to treat HIV infection. It belongs to a class of drugs called non-nucleoside reverse transcriptase inhibitors, which block the virus from multiplying in your body. Nevirapine is used in combination with other HIV medications to help control the infection and improve immune function.
Directions for Use
For how long do I take Nevirapine?
Nevirapine is usually a long-term medication for managing HIV infection. You'll typically take it every day as part of a lifelong treatment plan unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your condition to worsen. Always talk with your doctor before changing or stopping your Nevirapine treatment.
How do I dispose of Nevirapine?
To dispose of Nevirapine, take it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. Mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away.
How do I take Nevirapine?
Nevirapine is usually taken once or twice daily, depending on your doctor's instructions. You can take it with or without food. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Then, skip the missed dose and continue your regular schedule. Never take two doses at once. Always follow your doctor's specific advice about how to take Nevirapine.
How long does it take for Nevirapine to start working?
Nevirapine begins working in your body shortly after you take it, but it may take several weeks to see the full effects. Your doctor will monitor your viral load and CD4 count through regular blood tests to ensure the medication is working. How quickly Nevirapine works can depend on your overall health and adherence to the treatment plan.
How should I store Nevirapine?
Store Nevirapine at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms, as moisture can affect the medication. Always keep Nevirapine out of children's reach to prevent accidental swallowing. Check the expiration date regularly and dispose of any unused or expired medication properly.
What is the usual dose of Nevirapine?
The usual starting dose of Nevirapine for adults is 200 mg once daily for the first 14 days, followed by 200 mg twice daily. This helps reduce the risk of side effects. Your doctor may adjust your dose based on your response and any side effects. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can I take Nevirapine with other prescription drugs?
Nevirapine can interact with other medications, increasing the risk of side effects or reducing effectiveness. Drugs like rifampin, which is used to treat tuberculosis, can lower Nevirapine levels. Always inform your doctor about all medications you take to avoid interactions. Your doctor can adjust your treatment to ensure safety and effectiveness.
Can Nevirapine be taken safely while breastfeeding?
Nevirapine is not recommended while breastfeeding. It can pass into breast milk and may affect the baby. In areas where safe alternatives to breastfeeding are available, HIV-positive mothers are advised not to breastfeed to prevent transmission of the virus. Discuss with your doctor the best feeding options for your baby.
Can Nevirapine be taken safely while pregnant?
Nevirapine can be used during pregnancy, but it requires careful monitoring. It helps prevent mother-to-child transmission of HIV. However, it can cause liver problems, so regular liver function tests are important. Always discuss with your doctor the benefits and risks of using Nevirapine during pregnancy to ensure the best outcome for you and your baby.
Does Nevirapine have adverse effects?
Adverse effects are unwanted reactions to a medication. Nevirapine can cause skin rashes, liver problems, and allergic reactions. These effects can be serious and require immediate medical attention. If you notice symptoms like rash, fever, or yellowing of the skin, contact your doctor. Regular monitoring helps manage these risks.
Does Nevirapine have any safety warnings?
Yes, Nevirapine has important safety warnings. It can cause severe liver damage and skin reactions, which can be life-threatening. If you experience symptoms like rash, fever, fatigue, or yellowing of the skin or eyes, seek medical help immediately. Regular monitoring of liver function is recommended. Always follow your doctor's advice and report any unusual symptoms.
Is it safe to drink alcohol while taking Nevirapine?
It's best to avoid alcohol while taking Nevirapine. Alcohol can increase the risk of liver damage, which is a serious side effect of Nevirapine. If you choose to drink, limit your alcohol intake and monitor for symptoms like nausea, fatigue, or yellowing of the skin. Talk with your doctor about alcohol use while on Nevirapine.
Is it safe to exercise while taking Nevirapine?
You can exercise while taking Nevirapine, but listen to your body. Nevirapine can cause fatigue, so you might feel more tired during workouts. Stay hydrated and avoid overexertion. If you feel dizzy or unusually fatigued, slow down or stop exercising and rest. Consult your doctor if you have concerns about your exercise routine.
Is it safe to stop Nevirapine?
Stopping Nevirapine suddenly can cause your HIV to become resistant to treatment. It's important to follow your doctor's instructions and not stop taking Nevirapine without medical advice. Your doctor might suggest gradually reducing your dose or switching to a different medication to keep your condition under control.
Is Nevirapine addictive?
Nevirapine is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Nevirapine works by affecting the virus that causes HIV, not brain chemistry, so it doesn't lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Nevirapine safe for the elderly?
Elderly patients may be more vulnerable to side effects of Nevirapine, such as liver problems. Regular monitoring of liver function is important. The elderly may also have other health conditions that require careful management. Always consult your doctor about the risks and benefits of using Nevirapine if you are older.
What are the most common side effects of Nevirapine?
Side effects are unwanted reactions to a medication. Common side effects of Nevirapine include rash, fever, and nausea. These effects vary from person to person. If you notice new symptoms after starting Nevirapine, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Nevirapine?
Don't take Nevirapine if you've had a severe allergic reaction to it before. It's also contraindicated in people with severe liver problems. Nevirapine can cause serious liver damage, so regular monitoring is important. Always consult your doctor about any concerns and inform them of your medical history before starting Nevirapine.
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