Neratinib
Breast Neoplasms
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Neratinib
Summary
Neratinib is used to treat HER2-positive breast cancer, which is a type of cancer that has a protein promoting cancer cell growth. It helps reduce the risk of cancer coming back after initial treatment.
Neratinib works by blocking the HER2 protein, which promotes cancer cell growth. This action helps slow or stop the spread of cancer, reducing the risk of recurrence.
The usual dose of Neratinib for adults is 240 mg taken once daily with food. It's important to follow your doctor's specific instructions for your health needs.
Common side effects of Neratinib include diarrhea, which is frequent and can be severe, nausea, and fatigue, which is a feeling of tiredness or weakness.
Neratinib can cause severe diarrhea and liver problems. It's not recommended for those with severe liver impairment or allergies to its ingredients. Regular monitoring is advised.
Indications and Purpose
How does Neratinib work?
Neratinib works by blocking the HER2 protein, which promotes the growth of cancer cells. This action helps slow or stop the spread of cancer. Think of it like turning off a switch that powers cancer cell growth. By inhibiting this protein, Neratinib helps reduce the risk of cancer recurrence in patients with HER2-positive breast cancer.
Is Neratinib effective?
Neratinib is effective in treating certain types of breast cancer, particularly HER2-positive breast cancer. Clinical studies show that it helps reduce the risk of cancer recurrence when used after initial treatment. It works by blocking the HER2 protein, which promotes cancer cell growth. This medication is an important part of a comprehensive cancer treatment plan.
What is Neratinib?
Neratinib is a medication used to treat HER2-positive breast cancer. It belongs to a class of drugs called tyrosine kinase inhibitors, which block certain proteins that promote cancer cell growth. Neratinib is used after initial treatment to reduce the risk of cancer returning. It's an important part of a comprehensive cancer treatment plan.
Directions for Use
For how long do I take Neratinib?
Neratinib is usually taken long-term for managing certain types of breast cancer. The duration of use depends on your treatment plan and how your body responds. Your doctor will guide you on how long to continue the medication. Always talk with your doctor before changing or stopping your Neratinib treatment.
How do I dispose of Neratinib?
Dispose of unused Neratinib through a drug take-back program or collection site at a pharmacy or hospital. If these options aren't available, mix the medication with an undesirable substance like used coffee grounds, seal it in a plastic bag, and throw it away in the trash. This helps prevent harm to people and the environment.
How do I take Neratinib?
Take Neratinib once daily with food, preferably in the morning. Swallow the tablets whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for Neratinib to start working?
Neratinib starts working in your body shortly after you take it, but the full therapeutic effects may take several weeks to become noticeable. The time it takes to see results can vary based on individual factors like your overall health and how your body responds to the medication. Follow your doctor's instructions for the best results.
How should I store Neratinib?
Store Neratinib at room temperature, away from moisture and light. Keep it in its original container with the lid tightly closed. Avoid storing it in humid places like bathrooms. Always keep Neratinib out of reach of children to prevent accidental ingestion. Check the expiration date regularly and dispose of any unused or expired medication properly.
What is the usual dose of Neratinib?
The usual starting dose of Neratinib for adults is 240 mg taken once daily with food. Your doctor may adjust your dose based on your response and any side effects. Always follow your doctor's specific dosing instructions for your personal health needs. If you have any concerns about your dosage, discuss them with your healthcare provider.
Warnings and Precautions
Can I take Neratinib with other prescription drugs?
Neratinib can interact with certain medications, including proton pump inhibitors, which reduce stomach acid, and strong CYP3A4 inhibitors, which can increase Neratinib levels in your body. These interactions may increase the risk of side effects. Always inform your doctor about all medications you are taking to avoid potential interactions and ensure safe treatment.
Can Neratinib be taken safely while breastfeeding?
Neratinib is not recommended while breastfeeding. It's unclear if it passes into human breast milk, but it could pose risks to a nursing infant. If you're taking Neratinib and want to breastfeed, discuss safer medication options with your doctor. They can help you find a treatment plan that allows you to nurse safely.
Can Neratinib be taken safely while pregnant?
Neratinib is not recommended during pregnancy due to potential harm to the unborn baby. There is limited information on its safety in pregnant women, but animal studies suggest risks. If you're pregnant or planning to become pregnant, talk with your doctor about safer treatment options. Your doctor can help create a plan that protects both you and your baby.
Does Neratinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Neratinib include diarrhea, nausea, and fatigue. Diarrhea is the most frequent, affecting more than 90% of users. Serious side effects can include liver problems and severe dehydration. If you experience severe or persistent symptoms, contact your doctor. They can help manage side effects and adjust your treatment if necessary.
Does Neratinib have any safety warnings?
Yes, Neratinib has important safety warnings. It can cause severe diarrhea, which may lead to dehydration. It's crucial to manage this side effect with anti-diarrheal medications and hydration. Liver problems are another risk, so regular liver function tests are recommended. If you experience symptoms like yellowing of the skin or eyes, dark urine, or severe fatigue, contact your doctor immediately. Always adhere to your doctor's advice to minimize risks.
Is it safe to drink alcohol while taking Neratinib?
It's best to avoid alcohol while taking Neratinib. Alcohol can worsen side effects like diarrhea and dehydration. If you choose to drink occasionally, limit your intake and watch for symptoms like nausea or dizziness. These could indicate dehydration and require medical attention. Talk with your doctor about alcohol use while on Neratinib for personalized advice.
Is it safe to exercise while taking Neratinib?
You can exercise while taking Neratinib, but be cautious. This medication can cause diarrhea and dehydration, which might make you feel dizzy during exercise. To exercise safely, drink plenty of water before, during, and after physical activity. Watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest.
Is it safe to stop Neratinib?
Neratinib is usually used for long-term treatment of certain cancers. Stopping it suddenly can affect your treatment's effectiveness. Always talk with your doctor before stopping Neratinib. They might suggest a gradual reduction or an alternative treatment to ensure your condition remains under control. Your doctor will help you make any medication changes safely.
Is Neratinib addictive?
Neratinib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. If you have concerns about medication dependence, you can feel confident that Neratinib doesn't carry this risk while managing your health condition.
Is Neratinib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Neratinib, such as diarrhea and dehydration. These can lead to more serious complications in older adults. Regular monitoring and dose adjustments may be necessary. Always consult your doctor about the risks and benefits of Neratinib if you are elderly or caring for an elderly patient.
What are the most common side effects of Neratinib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Neratinib include diarrhea, nausea, and fatigue. Diarrhea is the most frequent, affecting more than 90% of users. If you notice new symptoms after starting Neratinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Neratinib?
Neratinib should not be used if you are allergic to it or any of its ingredients. It's also contraindicated in patients with severe liver impairment. Caution is needed for those with a history of severe diarrhea or dehydration. Always consult your doctor about your medical history before starting Neratinib to ensure it's safe for you.
