Nefazodone
Post-Traumatic Stress Disorders, Depressive Disorder
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Serotonin Reuptake Inhibitor
Controlled Drug Substance
No
nefazodone
Summary
Nefazodone is used to treat depression, which is a mood disorder causing persistent sadness and loss of interest. It may also be prescribed for other conditions as determined by your doctor.
Nefazodone works by affecting neurotransmitters, which are chemicals that transmit signals in the brain. It specifically modulates serotonin, which influences mood, by blocking its reuptake, thereby increasing serotonin levels and improving mood.
The usual starting dose of Nefazodone for adults is 100 mg taken twice daily. Your doctor may adjust the dose based on your response and needs, with a maximum recommended dose of 600 mg per day. It is taken orally, with or without food.
Common side effects of Nefazodone include dizziness, dry mouth, and nausea, which are unwanted reactions that can occur when taking a medication. These effects are usually mild and affect less than 10% of users.
Nefazodone can cause liver damage, which may be severe and life-threatening. It should not be used if you have liver disease or are taking MAO inhibitors, which are medications for depression. Regular liver function tests are recommended.
Indications and Purpose
How does Nefazodone work?
Nefazodone works by affecting neurotransmitters in the brain, which are chemicals that transmit signals. It specifically modulates serotonin, which is a neurotransmitter that influences mood, by blocking its reuptake. This increases serotonin levels in the brain, helping to improve mood and reduce symptoms of depression. Think of it like adjusting the volume on a radio to get a clearer sound. This mechanism makes Nefazodone effective for treating depression.
Is Nefazodone effective?
Yes, Nefazodone is effective for treating depression, which is a mood disorder causing persistent sadness. It works by balancing neurotransmitters in the brain, which are chemicals that transmit signals. Clinical studies show that Nefazodone can improve mood and reduce symptoms of depression. It may take several weeks to notice the full benefits. Always follow your doctor's instructions and attend regular check-ups to monitor your progress.
What is Nefazodone?
Nefazodone is an antidepressant medication that belongs to the class of drugs called serotonin modulators. It works by balancing neurotransmitters in the brain, which are chemicals that transmit signals. Nefazodone is primarily used to treat depression, which is a mood disorder causing persistent sadness. It may also be used for other conditions as determined by your doctor. Always follow your doctor's instructions when taking Nefazodone.
Directions for Use
For how long do I take Nefazodone?
Nefazodone is usually taken long-term for managing depression, which is a chronic condition. The duration of use depends on your response to the medication and any side effects you experience. Your doctor will guide you on how long to continue taking Nefazodone. Always talk with your doctor before changing or stopping your treatment to ensure it's done safely.
How do I dispose of Nefazodone?
Dispose of Nefazodone by taking it to a drug take-back program or collection site at a pharmacy or hospital. This ensures safe disposal without harming people or the environment. If a take-back program isn't available, you can throw it in the trash at home. First, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away. Always keep medications out of reach of children and pets.
How do I take Nefazodone?
Take Nefazodone as prescribed by your doctor, usually twice daily. You can take it with or without food. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose. Do not double up on doses. Avoid alcohol while taking Nefazodone, as it can increase side effects. Always follow your doctor's specific instructions regarding your medication schedule and any dietary restrictions.
How long does it take for Nefazodone to start working?
Nefazodone may start to improve symptoms of depression within one to two weeks, but it can take several weeks to achieve its full therapeutic effect. Individual factors like age, overall health, and other medications can affect how quickly you notice improvements. It's important to take Nefazodone exactly as prescribed and attend regular check-ups with your doctor to monitor your progress. If you have concerns about how long it's taking to work, talk with your healthcare provider.
How should I store Nefazodone?
Store Nefazodone at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Do not store it in humid places like bathrooms, as moisture can affect the medication's effectiveness. Always keep Nefazodone out of reach of children and pets. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Nefazodone?
The usual starting dose of Nefazodone for adults is 100 mg twice daily. Your doctor may adjust the dose based on your response and needs. The maximum recommended dose is 600 mg per day. Dose adjustments may be necessary for elderly patients or those with liver problems. Always follow your doctor's specific dosing instructions. Do not change your dose without consulting your healthcare provider.
Warnings and Precautions
Can I take Nefazodone with other prescription drugs?
Nefazodone has major interactions with certain medications, such as MAO inhibitors, which are used to treat depression, and certain antihistamines, which are used for allergies. These interactions can increase the risk of serious side effects like serotonin syndrome, which is a potentially life-threatening condition. Always inform your doctor about all medications you are taking to avoid harmful interactions. Your doctor can help manage your medications safely.
Can Nefazodone be taken safely while breastfeeding?
Nefazodone is not recommended while breastfeeding. Limited information is available on whether it passes into human breast milk. Animal studies suggest it may appear in milk, raising concerns for the baby's health. We don't have specific reports of harm to breastfed infants, but potential risks can't be ruled out. If you're breastfeeding and need treatment for depression, talk with your doctor about safer medication options that allow you to nurse safely.
Can Nefazodone be taken safely while pregnant?
Nefazodone is not recommended during pregnancy due to limited evidence on its safety. Animal studies suggest potential risks, but human data is lacking. Uncontrolled depression during pregnancy can cause problems for both mother and baby, such as preterm birth. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options. Your doctor can help create a plan that protects both you and your baby.
Does Nefazodone have adverse effects?
Yes, Nefazodone can have adverse effects, which are unwanted reactions to a medication. Common adverse effects include dizziness, dry mouth, and nausea. These occur in less than 10% of users. Serious adverse effects include liver damage, which requires immediate medical attention. If you experience symptoms like jaundice or severe fatigue, contact your doctor right away. Always inform your healthcare provider about any new or worsening symptoms while taking Nefazodone.
Does Nefazodone have any safety warnings?
Yes, Nefazodone has important safety warnings. It can cause liver damage, which may be severe and life-threatening. Symptoms include jaundice, which is yellowing of the skin or eyes, dark urine, and severe fatigue. If you notice these symptoms, seek medical help immediately. Regular liver function tests are recommended while taking Nefazodone. Not adhering to these warnings can lead to serious health consequences. Always follow your doctor's advice and report any unusual symptoms promptly.
Is it safe to drink alcohol while taking Nefazodone?
It's best to avoid alcohol while taking Nefazodone. Alcohol can increase the risk of side effects like dizziness and drowsiness, which can impair your ability to function. It may also worsen depression symptoms. If you choose to drink occasionally, limit your intake and watch for warning signs like increased drowsiness or mood changes. Talk with your doctor about alcohol use while taking Nefazodone for personalized advice.
Is it safe to exercise while taking Nefazodone?
Yes, you can exercise while taking Nefazodone. However, be aware that this medication can cause dizziness or drowsiness, which might affect your exercise capacity. If you feel dizzy or lightheaded during physical activity, slow down or stop and rest. Drink plenty of water to stay hydrated. Most people can maintain their regular exercise routine while taking Nefazodone, but check with your doctor if you have concerns about your specific situation.
Is it safe to stop Nefazodone?
No, it's not safe to stop Nefazodone suddenly without consulting your doctor. Nefazodone is usually used for long-term treatment of depression, which is a chronic condition. Stopping it abruptly can cause withdrawal symptoms like anxiety or mood changes. Your doctor may suggest gradually reducing the dose to minimize these effects. Always talk with your healthcare provider before making any changes to your medication regimen.
Is Nefazodone addictive?
No, Nefazodone is not considered addictive or habit-forming. It does not cause physical or psychological dependence. Nefazodone works by affecting neurotransmitters in the brain, which are chemicals that transmit signals. This mechanism does not lead to addiction. You won't experience cravings or withdrawal symptoms when stopping Nefazodone. However, always consult your doctor before stopping any medication to ensure it's done safely.
Is Nefazodone safe for the elderly?
Elderly individuals are more vulnerable to the safety risks of medications like Nefazodone due to age-related changes in metabolism and organ function. Nefazodone can cause dizziness and drowsiness, which may increase the risk of falls in older adults. Regular monitoring and dose adjustments may be necessary. Always consult your doctor about the risks and benefits of Nefazodone if you are elderly or caring for an elderly person.
What are the most common side effects of Nefazodone?
Common side effects of Nefazodone include dizziness, dry mouth, and nausea. These side effects are unwanted reactions that can occur when taking a medication. They affect less than 10% of people using Nefazodone. If you experience new symptoms after starting the medication, they might be temporary or unrelated. Always talk with your doctor before stopping any medication. Your doctor can help determine if the side effects are related to Nefazodone and suggest ways to manage them.
Who should avoid taking Nefazodone?
Nefazodone should not be used if you have liver disease, which affects the organ that processes toxins. This is an absolute contraindication due to the risk of severe liver damage. It's also contraindicated with certain medications like MAO inhibitors, which are used to treat depression, due to the risk of serious interactions. Always inform your doctor about your medical history and current medications to ensure Nefazodone is safe for you.
