Naproxen + Sumatriptan
Find more information about this combination medication at the webpages for Naproxen and Sumatriptan
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Advisory
- This medicine contains a combination of 2 drugs: Naproxen and Sumatriptan.
- Based on evidence, Naproxen and Sumatriptan are more effective when taken together.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Nonsteroidal Anti-inflammatory Drug and Serotonin-1b and Serotonin-1d Receptor Agonist
Controlled Drug Substance
NO
Summary
Naproxen and Sumatriptan are used together to treat acute migraine headaches. They work by addressing both the vascular and inflammatory components of the headache. Please note, they are not intended for the prevention of migraines or for treating other types of headaches.
Sumatriptan works by narrowing blood vessels in the brain and blocking pain signals, which helps alleviate headache pain. Naproxen, an anti-inflammatory drug, reduces inflammation and pain. When combined, these medications provide a comprehensive approach to managing migraines by addressing both pain and inflammation.
The typical dose of Naproxen and Sumatriptan combination is one tablet containing 85 mg of Sumatriptan and 500 mg of Naproxen. This combination is usually taken at the onset of a migraine. If symptoms improve but return, a second dose may be taken after at least 2 hours, with a maximum of two doses in a 24-hour period.
Common side effects of Naproxen and Sumatriptan include dizziness, drowsiness, nausea, and stomach upset. Sumatriptan may cause sensations of tingling, warmth, or pressure, while Naproxen can lead to gastrointestinal issues like heartburn or indigestion. Serious side effects include cardiovascular events such as heart attack or stroke, gastrointestinal bleeding, and severe allergic reactions.
Naproxen and Sumatriptan should not be used in patients with a history of heart disease, stroke, or uncontrolled hypertension, which means high blood pressure. They should also not be used in patients with severe liver or kidney impairment. Naproxen can cause gastrointestinal bleeding, especially in older adults or those with a history of ulcers. Sumatriptan should not be used with other similar drugs due to the risk of additive effects.
Indications and Purpose
What is combination of Naproxen and Sumatriptan used for?
Sumatriptan is indicated for the acute treatment of migraine headaches, with or without aura, in adults. Naproxen is used to relieve pain and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, gout, and menstrual cramps. While sumatriptan is specifically for migraines, naproxen addresses a wider range of pain and inflammatory conditions. Both medications are used to manage acute symptoms and improve patient comfort.
How does combination of Naproxen and Sumatriptan work?
Sumatriptan works by activating serotonin receptors in the brain, which leads to the narrowing of blood vessels and blocking of pain signals, effectively treating migraines. Naproxen, an NSAID, inhibits the production of prostaglandins, substances in the body that cause inflammation and pain. While sumatriptan specifically targets migraine pathways, naproxen provides a broader anti-inflammatory and analgesic effect. Both medications help alleviate pain, but through different mechanisms, making them complementary in treating migraine symptoms.
How effective is combination of Naproxen and Sumatriptan?
Clinical trials have demonstrated that sumatriptan effectively reduces migraine symptoms, such as headache, nausea, and sensitivity to light and sound, within a few hours of administration. Naproxen has been shown to effectively reduce pain and inflammation in conditions like arthritis, gout, and menstrual cramps. Both medications have been proven to improve patient quality of life by alleviating symptoms and allowing for normal daily activities. The combination of these medications can provide comprehensive relief for migraine sufferers by addressing both pain and inflammation.
How does one know if combination of Naproxen and Sumatriptan is working?
The benefit of sumatriptan is assessed by its ability to relieve migraine symptoms, such as headache, nausea, and sensitivity to light and sound, within a few hours of administration. Naproxen's effectiveness is measured by its ability to reduce pain and inflammation in conditions like arthritis and acute injuries. Both medications are considered effective if they provide significant symptom relief and improve the patient's quality of life. Regular monitoring and communication with a healthcare provider are essential to ensure optimal outcomes and adjust treatment as needed.
Directions for Use
What is the usual dose of combination of Naproxen and Sumatriptan?
For sumatriptan, the usual adult dose is 25 mg, 50 mg, or 100 mg, taken at the first sign of a migraine. If symptoms persist, a second dose can be taken after 2 hours, with a maximum of 200 mg in 24 hours. Naproxen's typical adult dose for pain relief is 500 mg to 1000 mg per day, divided into two doses, with a maximum of 1500 mg per day for short-term use. Both medications should be used as directed by a healthcare provider, and it's important not to exceed the recommended doses to avoid adverse effects.
How does one take combination of Naproxen and Sumatriptan?
Sumatriptan can be taken with or without food, but taking it with food may help reduce stomach upset. Naproxen should be taken with food or milk to minimize gastrointestinal discomfort. It's important to follow the specific instructions provided by a healthcare provider or pharmacist for each medication. Both medications should be taken with a full glass of water, and patients should avoid alcohol to reduce the risk of stomach irritation and other side effects.
For how long is combination of Naproxen and Sumatriptan taken?
Sumatriptan is used on an as-needed basis for acute migraine attacks and is not intended for long-term use or prevention. Naproxen can be used for both short-term relief of acute pain and inflammation and for longer-term management of chronic conditions like arthritis. However, prolonged use of naproxen should be monitored by a healthcare provider due to potential side effects. Both medications should be used according to the prescribed guidelines to minimize risks.
How long does it take for combination of Naproxen and Sumatriptan to work?
Sumatriptan typically begins to work within 30 minutes to 2 hours after taking it, providing relief from migraine symptoms. Naproxen, on the other hand, can start to relieve pain and inflammation within 1 hour, with its effects lasting longer due to its extended-release formulation. Both medications are used to treat acute conditions, with sumatriptan targeting migraines specifically and naproxen addressing various types of pain and inflammation. The combination of these two medications can provide a more comprehensive approach to managing migraine symptoms by addressing both pain and inflammation.
How does one store combination of Naproxen and Sumatriptan?
Neither naproxen nor sumatriptan requires refrigeration. Both medications should be stored at room temperature, away from excess heat and moisture, and kept in their original containers with the lids tightly closed. It's important to keep these medications out of reach of children and pets to prevent accidental ingestion. Proper storage ensures the medications maintain their effectiveness and safety.
Warnings and Precautions
Are there harms and risks from taking combination of Naproxen and Sumatriptan?
Common side effects of sumatriptan include flushing, tingling, drowsiness, and dizziness. Serious side effects can include chest pain, shortness of breath, and changes in vision. Naproxen may cause side effects such as stomach pain, heartburn, dizziness, and drowsiness. Serious adverse effects include gastrointestinal bleeding, ulcers, and increased risk of heart attack or stroke. Both medications can cause dizziness and drowsiness, and patients should be cautious when driving or operating machinery. It's important to monitor for serious side effects and seek medical attention if they occur.
Can I take combination of Naproxen and Sumatriptan with other prescription drugs?
Sumatriptan should not be taken with other migraine medications like ergotamines or other triptans within 24 hours due to the risk of serious cardiovascular side effects. Naproxen can interact with anticoagulants, increasing the risk of bleeding, and may reduce the effectiveness of antihypertensive drugs. Both medications can interact with SSRIs and SNRIs, increasing the risk of serotonin syndrome. Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions and ensure safe use.
Can I take combination of Naproxen and Sumatriptan with vitamins or supplements?
There are no specific interactions between sumatriptan and vitamins or supplements. However, naproxen may interact with certain supplements, such as those that affect blood clotting, like vitamin E or omega-3 fatty acids, potentially increasing the risk of bleeding. Patients should inform their healthcare provider about all supplements they are taking to avoid potential interactions. It's important to use caution and consult a healthcare provider before starting any new supplements while on these medications.
Can I take combination of Naproxen and Sumatriptan if I am pregnant?
Sumatriptan is generally considered safe during pregnancy, but it should only be used if the potential benefits outweigh the risks. Naproxen, like other NSAIDs, is not recommended during the third trimester due to the risk of premature closure of the fetal ductus arteriosus and other complications. Both medications should be used with caution during pregnancy, and only under the guidance of a healthcare provider, to ensure the safety of both the mother and the developing fetus.
Can I take combination of Naproxen and Sumatriptan while breastfeeding?
Sumatriptan is excreted in breast milk, but the amount is generally low, and it is considered relatively safe for use during breastfeeding. However, it is recommended to avoid breastfeeding for 12 hours after taking sumatriptan to minimize infant exposure. Naproxen is also excreted in breast milk, and while it is generally considered safe, prolonged use should be avoided due to potential effects on the infant. Both medications should be used under the guidance of a healthcare provider during lactation to ensure safety for the infant.
Who should avoid taking combination of Naproxen and Sumatriptan?
Sumatriptan is contraindicated in patients with a history of heart disease, stroke, or uncontrolled hypertension due to the risk of serious cardiovascular events. Naproxen should be used with caution in patients with a history of gastrointestinal bleeding or ulcers, as it can increase the risk of these conditions. Both medications should be used cautiously in patients with liver or kidney disease. Patients should inform their healthcare provider of their full medical history to ensure safe use and avoid potential complications.
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