Mupirocin
Impetigo
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
RNA Synthetase Inhibitor Antibacterial
Controlled Drug Substance
No
Summary
Mupirocin is used to treat skin infections like impetigo, which causes red sores, and other bacterial skin infections such as folliculitis, which is inflammation of hair follicles, and furunculosis, which are boils. It helps by stopping the growth of bacteria on the skin, promoting healing.
Mupirocin works by inhibiting bacterial protein synthesis, which is the process bacteria use to make proteins necessary for their growth and survival. It targets an enzyme called isoleucyl-tRNA synthetase, preventing bacteria from producing essential proteins, thus stopping their growth.
Mupirocin is applied topically, which means directly on the skin, to the affected area. The usual dose for adults is a small amount of ointment applied two to three times daily. The frequency may vary based on the infection's severity and your doctor's instructions.
Common side effects of mupirocin include mild burning, stinging, or itching at the application site. These effects are usually temporary and resolve on their own. If new symptoms appear, they might be unrelated to the medication. Consult your doctor if side effects persist or worsen.
Mupirocin is for external use only and should not be used in the eyes, nose, or mouth. Avoid using it on large areas of damaged skin or for prolonged periods. If severe skin irritation or allergic reactions occur, stop using mupirocin and consult your doctor immediately.
Indications and Purpose
How does mupirocin work?
Mupirocin works by inhibiting bacterial protein synthesis, which is the process bacteria use to make proteins necessary for their growth and survival. It specifically targets an enzyme called isoleucyl-tRNA synthetase, preventing bacteria from producing essential proteins. Think of it like cutting off the supply line to a factory, stopping production. This action helps clear skin infections like impetigo by stopping the growth of bacteria on the skin.
Is mupirocin effective?
Yes, mupirocin is effective for treating skin infections like impetigo, which is a bacterial infection causing red sores. It works by stopping the growth of bacteria on the skin. Clinical studies support its effectiveness in clearing infections and improving skin health. Mupirocin is often used when other antibiotics are not suitable or effective. Always use it as directed by your doctor for the best results.
What is mupirocin?
Mupirocin is a topical antibiotic used to treat skin infections like impetigo, which causes red sores. It belongs to the class of antibiotics called monoxycarbolic acids. Mupirocin works by stopping the growth of bacteria on the skin, helping to clear the infection. It is applied directly to the affected area and is often used when other antibiotics are not suitable or effective. Always use mupirocin as directed by your doctor.
Directions for Use
For how long do I take mupirocin?
Mupirocin is used for short-term treatment of acute skin infections. The usual duration is 5 to 10 days, depending on the severity of the infection and your doctor's instructions. It is important to complete the full course of treatment to ensure the infection is fully cleared. Do not stop using mupirocin without consulting your doctor, even if symptoms improve, to prevent recurrence of the infection.
How do I dispose of mupirocin?
To dispose of mupirocin, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away.
How do I take mupirocin?
Mupirocin is applied topically to the affected area of the skin. Clean and dry the area before applying a small amount of the ointment. Use it two to three times daily, as directed by your doctor. Do not cover the treated area with a bandage unless instructed. Avoid getting it in your eyes, nose, or mouth. If you miss a dose, apply it as soon as you remember, unless it's almost time for the next dose. Do not double up on doses.
How long does it take for mupirocin to start working?
Mupirocin starts working soon after application, with noticeable improvement in skin infections like impetigo within a few days. The full therapeutic effect may take up to 10 days, depending on the severity of the infection and adherence to the treatment regimen. Factors like the size of the infected area and individual response can affect how quickly mupirocin works. Always use it as directed by your doctor for the best results.
How should I store mupirocin?
Store mupirocin at room temperature, away from moisture and light. Keep it in its original container, tightly closed, to protect it from environmental factors that could affect its effectiveness. Do not refrigerate or freeze mupirocin. Avoid storing it in humid places like bathrooms. Always keep mupirocin out of reach of children to prevent accidental ingestion. Check the expiration date regularly and dispose of any unused or expired medication properly.
What is the usual dose of mupirocin?
The usual dose of mupirocin for adults is to apply a small amount of the ointment to the affected area of the skin two to three times daily. The frequency of application may vary based on the severity of the infection and your doctor's instructions. Mupirocin is not typically used in children under 12 years without medical advice. Always follow your doctor's specific dosing instructions for your condition.
Warnings and Precautions
Can I take mupirocin with other prescription drugs?
Mupirocin is a topical antibiotic with minimal systemic absorption, so it has a low risk of interacting with other prescription drugs. However, avoid using other topical medications on the same area without consulting your doctor, as this could affect mupirocin's effectiveness. Always inform your doctor about all medications you are taking to ensure safe and effective treatment. If you have concerns about drug interactions, discuss them with your healthcare provider.
Can mupirocin be taken safely while breastfeeding?
Mupirocin is generally safe to use while breastfeeding, as it is a topical antibiotic with minimal absorption into the bloodstream. There is limited evidence on its excretion into breast milk, but it is unlikely to affect the breastfed infant or milk supply. Always consult your doctor before using mupirocin while breastfeeding to ensure it is appropriate for your situation and to discuss any concerns you may have.
Can mupirocin be taken safely while pregnant?
Mupirocin is generally considered safe to use during pregnancy, as it is a topical antibiotic with minimal absorption into the bloodstream. However, there is limited evidence on its absolute safety during pregnancy. Always consult your doctor before using mupirocin if you are pregnant or planning to become pregnant. They can help determine if the benefits outweigh any potential risks for your specific situation.
Does mupirocin have adverse effects?
Adverse effects are unwanted reactions to a medication. Mupirocin can cause mild side effects like burning, stinging, or itching at the application site. These effects are usually temporary. Serious adverse effects are rare but can include severe skin irritation or allergic reactions. If you notice any new or worsening symptoms, stop using mupirocin and contact your doctor. They can help determine if the symptoms are related to the medication and suggest appropriate actions.
Does mupirocin have any safety warnings?
Yes, mupirocin has safety warnings. It is for external use only and should not be used in the eyes, nose, or mouth. Using it on large areas of damaged skin or for prolonged periods can lead to systemic absorption and potential side effects. If you experience severe skin irritation, allergic reactions, or no improvement in your condition, stop using mupirocin and consult your doctor. Not adhering to these warnings can lead to ineffective treatment or adverse effects.
Is it safe to drink alcohol while taking mupirocin?
Yes, you can drink alcohol while using mupirocin. There are no known interactions between mupirocin, which is a topical antibiotic, and alcohol. Since mupirocin is applied to the skin and not absorbed into the bloodstream in significant amounts, it does not interact with alcohol. However, always use alcohol in moderation and consult your doctor if you have any concerns about your medications and alcohol use.
Is it safe to exercise while taking mupirocin?
Yes, it is safe to exercise while using mupirocin. Mupirocin is a topical antibiotic used for skin infections and does not affect your ability to exercise. However, if the infection is on a part of the body that might be irritated by exercise, such as a joint, you may want to avoid strenuous activities until it heals. Always listen to your body and consult your doctor if you have concerns about exercising while using mupirocin.
Is it safe to stop mupirocin?
Yes, it is generally safe to stop using mupirocin once your doctor advises that your skin infection has cleared. Mupirocin is used for short-term treatment of acute skin infections. Stopping it before the infection is fully treated may lead to a return of the infection. Always follow your doctor's instructions on the duration of use to ensure complete healing and prevent recurrence.
Is mupirocin addictive?
No, mupirocin is not addictive. It is a topical antibiotic used to treat skin infections and does not have habit-forming potential. Mupirocin works by stopping the growth of bacteria on the skin and does not affect brain chemistry in ways that could lead to addiction. You will not experience cravings or withdrawal symptoms when you stop using mupirocin.
Is mupirocin safe for the elderly?
Yes, mupirocin is generally safe for the elderly. However, older adults may have more sensitive skin, which can increase the risk of irritation. Mupirocin is a topical antibiotic used for skin infections and is not absorbed into the bloodstream in significant amounts, reducing systemic risks. Always follow your doctor's instructions and report any unusual symptoms or skin reactions. Your doctor can help ensure safe and effective use of mupirocin.
What are the most common side effects of mupirocin?
Side effects are unwanted reactions to a medication. Common side effects of mupirocin include mild burning, stinging, or itching at the application site. These effects are usually temporary and resolve on their own. If you notice new symptoms after starting mupirocin, they might be unrelated to the medication. Consult your doctor if side effects persist or worsen. They can help determine if the symptoms are related to mupirocin or another cause.
Who should avoid taking mupirocin?
Mupirocin should not be used if you are allergic to it or any of its ingredients. Serious allergic reactions, which cause rash, hives, or swelling that makes breathing difficult, require immediate medical help. Avoid using mupirocin on large areas of damaged skin or for prolonged periods, as this can lead to systemic absorption and potential side effects. Always consult your doctor if you have concerns about using mupirocin.
