Moexipril
Hypertension, Left Ventricular Dysfunction ... show more
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Angiotensin Converting Enzyme Inhibitor
Controlled Drug Substance
No
Moexipril
Summary
Moexipril is primarily used to treat high blood pressure, also known as hypertension. By managing your blood pressure levels, it helps prevent serious complications such as heart disease, stroke, and kidney damage.
Moexipril is an ACE inhibitor. It works by reducing certain chemicals that tighten your blood vessels. This allows your blood to flow more smoothly and your heart to pump more efficiently.
The usual starting dose for adults is 7.5 mg taken once daily, one hour before meals. The dose may be adjusted based on your blood pressure response, with a typical range of 7.5 to 30 mg per day.
Common side effects of Moexipril include cough, dizziness, and diarrhea. If you experience any severe side effects, you should contact your doctor immediately.
Moexipril should not be used during pregnancy due to the risk of harming the fetus. It's also not recommended for patients with a history of swelling related to ACE inhibitors. Caution is advised in patients with kidney impairment.
Indications and Purpose
How does Moexipril work?
Moexipril is a prodrug that is converted to its active form, moexiprilat, in the body. It inhibits the angiotensin-converting enzyme (ACE), which decreases the production of angiotensin II, a substance that narrows blood vessels. This leads to vasodilation, reduced blood pressure, and decreased workload on the heart.
Is Moexipril effective?
Moexipril is an ACE inhibitor that effectively lowers blood pressure by decreasing certain chemicals that tighten blood vessels. Clinical trials have shown that it reduces sitting diastolic and systolic blood pressure, with effects evident within 2 weeks and maximal reduction after 4 weeks. It is effective in both pre- and postmenopausal women and has been proven to continue its antihypertensive effects for up to 24 months.
What is Moexipril?
Moexipril is used to treat high blood pressure. It belongs to a class of medications called ACE inhibitors, which work by decreasing certain chemicals that tighten blood vessels, allowing blood to flow more smoothly and the heart to pump more efficiently. This helps to lower blood pressure and reduce the risk of heart disease and stroke.
Directions for Use
For how long do I take Moexipril?
Moexipril is typically used as a long-term treatment for high blood pressure. It is important to continue taking it even if you feel well, as it controls blood pressure but does not cure it. Always follow your doctor's instructions regarding the duration of use.
How do I take Moexipril?
Moexipril should be taken on an empty stomach, one hour before or two hours after a meal. It is important to take it at the same time every day to help remember. Avoid using salt substitutes containing potassium unless advised by your doctor. Always follow your doctor's instructions regarding food restrictions.
How long does it take for Moexipril to start working?
Moexipril begins to lower blood pressure within about 1 hour after dosing, with peak effects occurring between 3 and 6 hours after dosing. The full antihypertensive effect is generally evident within 2 weeks of treatment, with maximal reduction after 4 weeks.
How should I store Moexipril?
Moexipril should be stored in its original container, tightly closed, at room temperature away from excess heat and moisture. It should be kept out of reach of children. Unneeded medication should be disposed of through a take-back program, not flushed down the toilet. Consult your pharmacist for more information on safe disposal.
What is the usual dose of Moexipril?
The usual daily dose of Moexipril for adults is 7.5 mg to 30 mg, taken once or twice a day. It should be taken on an empty stomach, one hour before or two hours after a meal. The dosage for children has not been established, so it is not recommended for pediatric use. Always follow your doctor's advice for the correct dosage.
Warnings and Precautions
Can I take Moexipril with other prescription drugs?
Moexipril should not be taken with valsartan and sacubitril, or aliskiren in patients with diabetes. It may interact with NSAIDs, potassium supplements, and potassium-sparing diuretics, increasing the risk of hyperkalemia. Always discuss any medications you are taking with your doctor to avoid interactions.
Can Moexipril be taken safely while breastfeeding?
It is not known whether Moexipril is excreted in human milk. Caution should be exercised when it is given to a nursing mother. Always consult your doctor for personalized advice regarding the use of Moexipril while breastfeeding.
Can Moexipril be taken safely while pregnant?
Moexipril is not recommended during pregnancy as it can harm the fetus, especially during the second and third trimesters. It can cause fetal renal dysfunction, leading to oligohydramnios and other complications. If pregnancy is detected, discontinue Moexipril immediately and consult your doctor for alternative treatments.
Is it safe to drink alcohol while taking Moexipril?
Drinking alcohol can lower your blood pressure and may increase certain side effects of Moexipril. It is advisable to limit alcohol consumption while taking this medication. Always consult your doctor for personalized advice regarding alcohol use.
Is it safe to exercise while taking Moexipril?
Moexipril does not specifically limit the ability to exercise. However, it can cause dizziness or lightheadedness, which might affect physical activity. If you experience these symptoms, it is advisable to avoid strenuous activities and consult your doctor for guidance.
Is Moexipril safe for the elderly?
Elderly patients may have a greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Therefore, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range. Always consult a doctor for personalized advice.
Who should avoid taking Moexipril?
Moexipril should not be used during pregnancy as it can harm the fetus. It is contraindicated in patients with a history of angioedema related to previous ACE inhibitor treatment. Patients with diabetes should not take it with aliskiren. It can cause symptomatic hypotension, especially in those who are salt- and volume-depleted. Always consult your doctor for personalized advice.
