Metyrapone
NA
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Possible
Pharmaceutical Class
Adrenal Steroid Synthesis Inhibitor
Controlled Drug Substance
No
Metyrapone
Summary
Metyrapone is used to diagnose and treat adrenal gland disorders, which are conditions affecting hormone production in the adrenal glands. It is particularly effective for managing Cushing's syndrome, which is when the body produces too much cortisol, a hormone that helps regulate metabolism and stress response.
Metyrapone works by blocking an enzyme in the adrenal glands, which reduces cortisol production. Cortisol is a hormone that helps control metabolism and stress. By lowering cortisol levels, Metyrapone helps balance hormone levels in the body, which is crucial for managing conditions like Cushing's syndrome.
The usual starting dose of Metyrapone for adults is 750 mg to 1,000 mg per day, divided into two or three doses. The maximum recommended dose is 6,000 mg per day. It is typically taken orally, which means by mouth, and should be taken with food to reduce stomach upset.
Common side effects of Metyrapone include nausea, which is feeling sick to your stomach, dizziness, which is feeling lightheaded, and fatigue, which is feeling very tired. These effects can vary from person to person and may be temporary or unrelated to the medication.
Metyrapone should not be taken by people allergic to it or its ingredients. It is not recommended for those with adrenal gland tumors, which can cause hormone imbalances. Caution is advised for individuals with liver or kidney problems, as these conditions may affect how the body processes the medication.
Indications and Purpose
How does Metyrapone work?
Metyrapone works by blocking an enzyme in the adrenal glands, which reduces cortisol production. Think of it like turning down the volume on a radio. This helps manage conditions like Cushing's syndrome, which is when your body produces too much cortisol. By lowering cortisol levels, Metyrapone helps balance hormone levels.
Is Metyrapone effective?
Metyrapone is effective for diagnosing and treating adrenal gland disorders. It works by blocking cortisol production, which helps manage conditions like Cushing's syndrome, which is when your body produces too much cortisol. Clinical studies support its effectiveness in managing these conditions.
What is Metyrapone?
Metyrapone is a medication used to diagnose and treat adrenal gland disorders. It works by blocking cortisol production, which helps manage conditions like Cushing's syndrome, which is when your body produces too much cortisol. Metyrapone is part of a class of drugs called adrenal corticosteroid inhibitors.
Directions for Use
For how long do I take Metyrapone?
Metyrapone is usually used for short-term treatment to diagnose or manage adrenal gland disorders. The duration of use depends on your specific condition and how your body responds. Always follow your doctor's instructions regarding how long to take Metyrapone. Your doctor will guide you based on your health needs.
How do I dispose of Metyrapone?
Bring unused Metyrapone to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away.
How do I take Metyrapone?
Take Metyrapone as directed by your doctor, usually once or twice daily. It's best to take it with food to reduce stomach upset. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not double up on doses. Always follow your doctor's specific instructions for taking Metyrapone.
How long does it take for Metyrapone to start working?
Metyrapone begins working shortly after you take it, but the full effects may take a few days to become noticeable. The time it takes to work can depend on your specific condition and how your body responds. Always take Metyrapone as prescribed for the best results.
How should I store Metyrapone?
Store Metyrapone at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. Always keep Metyrapone out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Metyrapone?
The usual starting dose of Metyrapone for adults is 750 mg to 1,000 mg per day, divided into two or three doses. Your doctor may adjust your dose based on your response and needs. The maximum recommended dose is 6,000 mg per day. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can I take Metyrapone with other prescription drugs?
Metyrapone can interact with certain medications, such as corticosteroids, which may affect its effectiveness. Always inform your doctor about all the medications you are taking to avoid potential interactions. Your doctor can help manage any interactions and adjust your treatment plan as needed.
Can Metyrapone be taken safely while breastfeeding?
Metyrapone is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. If you're taking Metyrapone and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Metyrapone be taken safely while pregnant?
Metyrapone isn't recommended during pregnancy unless absolutely necessary. Limited data is available on its safety in pregnant women. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a pregnancy-specific treatment plan.
Does Metyrapone have adverse effects?
Adverse effects are unwanted reactions to a medication. Metyrapone can cause nausea, dizziness, or fatigue, which are common side effects. Serious side effects include adrenal insufficiency, which is when your adrenal glands don't produce enough hormones. If you notice any new or worsening symptoms, contact your doctor. They can help determine if these symptoms are related to Metyrapone.
Does Metyrapone have any safety warnings?
Metyrapone has important safety warnings. It can affect your adrenal glands, which produce hormones. Not following your doctor's instructions can lead to hormone imbalances. If you experience symptoms like fatigue, dizziness, or nausea, contact your doctor. These could be signs of adrenal insufficiency, which is when your adrenal glands don't produce enough hormones.
Is it safe to drink alcohol while taking Metyrapone?
It's best to avoid alcohol while taking Metyrapone. Alcohol can interfere with the medication's effectiveness and increase the risk of side effects like dizziness or nausea. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs. Talk with your doctor about alcohol use while taking Metyrapone.
Is it safe to exercise while taking Metyrapone?
You can exercise while taking Metyrapone, but keep a few things in mind. This medication can cause dizziness or fatigue, which might affect your exercise capacity. To exercise safely, drink plenty of water and watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest.
Is it safe to stop Metyrapone?
Stopping Metyrapone suddenly can cause problems. If you're taking it for adrenal gland issues, stopping might worsen your condition. Always talk with your doctor before stopping Metyrapone. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control.
Is Metyrapone addictive?
Metyrapone is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Metyrapone works by affecting hormone production in your adrenal glands, which doesn't lead to addiction. If you have concerns about medication dependence, you can feel confident that Metyrapone doesn't carry this risk.
Is Metyrapone safe for the elderly?
Elderly individuals may be more vulnerable to the side effects of Metyrapone, such as dizziness or fatigue. It's important for older adults to be closely monitored by their doctor while taking this medication. Your doctor may adjust the dose to minimize risks and ensure safety.
What are the most common side effects of Metyrapone?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Metyrapone include nausea, dizziness, and fatigue. These effects vary from person to person. If you notice new symptoms after starting Metyrapone, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Metyrapone?
Don't take Metyrapone if you're allergic to it or its ingredients. It's not for people with adrenal gland tumors, which can cause hormone imbalances. Metyrapone should be used with caution in people with liver or kidney problems, as it may affect how the body processes the medication. Always consult your doctor about these concerns.
