Methazolamide
Angle-Closure Glaucoma, Open-Angle Glaucoma
.svg)
Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
NA
Controlled Drug Substance
NO
Methazolamide
Summary
Methazolamide is primarily used to treat glaucoma, including chronic open-angle glaucoma, secondary glaucoma, and to lower intraocular pressure before surgery in acute angle-closure glaucoma.
Methazolamide works by inhibiting an enzyme called carbonic anhydrase, which is involved in the production of a fluid in the eye called aqueous humor. By reducing the production of this fluid, it lowers the pressure inside the eye, helping to manage glaucoma.
Methazolamide is typically taken orally two or three times a day, with doses ranging from 50 mg to 100 mg. Always follow your doctor's instructions regarding dosage and administration.
Common side effects of Methazolamide include drowsiness, fatigue, nausea, vomiting, and diarrhea. More serious side effects can include severe skin reactions and blood disorders, though these are not common.
Methazolamide should not be used by patients with severe kidney or liver disease, adrenal gland failure, or a specific type of acidosis. It should also not be used for long-term treatment of angle-closure glaucoma. If you're pregnant, nursing, or taking other medications like high-dose aspirin or steroids, you should discuss these factors with your doctor.
Indications and Purpose
How does Methazolamide work?
Methazolamide works by inhibiting the enzyme carbonic anhydrase, which reduces the production of aqueous humor in the eye. This leads to a decrease in intraocular pressure, helping to manage conditions like glaucoma and prevent vision loss.
Is Methazolamide effective?
Methazolamide is a carbonic anhydrase inhibitor that effectively reduces intraocular pressure in conditions like glaucoma. It decreases the secretion of aqueous humor in the eye, leading to a reduction in pressure. Clinical studies have shown its effectiveness in managing glaucoma symptoms.
What is Methazolamide?
Methazolamide is used to treat glaucoma by reducing intraocular pressure. It belongs to a class of medications called carbonic anhydrase inhibitors, which decrease the production of aqueous humor in the eye. This helps prevent damage to the optic nerve and loss of vision.
Directions for Use
For how long do I take Methazolamide?
Methazolamide is used to control glaucoma but does not cure it, so it is typically taken long-term. Continue taking it as prescribed by your doctor, even if you feel well.
How do I take Methazolamide?
Methazolamide is taken orally, usually two or three times a day. It can be taken with or without food. There are no specific food restrictions, but always follow your doctor's instructions and consult them if you have any dietary concerns.
How long does it take for Methazolamide to start working?
Methazolamide generally starts to decrease intraocular pressure within 2 to 4 hours after administration, with peak effects occurring in 6 to 8 hours. The total duration of action is typically 10 to 18 hours.
How should I store Methazolamide?
Store Methazolamide at room temperature, away from excess heat and moisture. Keep it in its original container, tightly closed, and out of reach of children. Do not store it in the bathroom. Dispose of unneeded medication through a take-back program.
What is the usual dose of Methazolamide?
The usual adult dose for Methazolamide is 50 mg to 100 mg taken two or three times daily. The safety and effectiveness of Methazolamide in children have not been established, so dosing for children is not provided. Always follow your doctor's advice for the correct dosage.
Warnings and Precautions
Can I take Methazolamide with other prescription drugs?
Methazolamide can interact with high-dose aspirin, leading to serious side effects like lethargy and coma. It should be used cautiously with steroids due to the risk of hypokalemia. Always inform your doctor about all medications you are taking to avoid harmful interactions.
Can Methazolamide be taken safely while breastfeeding?
It is not known whether Methazolamide is excreted in human milk. Due to the potential for serious adverse reactions in nursing infants, a decision should be made to either discontinue nursing or discontinue the drug, considering its importance to the mother.
Can Methazolamide be taken safely while pregnant?
Methazolamide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It has shown teratogenic effects in animal studies, but there are no adequate human studies. Consult your doctor for personalized advice if you are pregnant or planning to become pregnant.
Is it safe to exercise while taking Methazolamide?
Methazolamide may cause drowsiness or fatigue, which could affect your ability to exercise. If you experience these symptoms, it is advisable to avoid strenuous activities until you know how the medication affects you. Consult your doctor if you have concerns about exercising while on this medication.
Is Methazolamide safe for the elderly?
Elderly patients should use Methazolamide with caution, as they may be more sensitive to its effects, particularly drowsiness and electrolyte imbalances. Regular monitoring by a healthcare provider is recommended to ensure safe use.
Who should avoid taking Methazolamide?
Methazolamide is contraindicated in patients with severe kidney or liver disease, adrenal gland failure, and certain electrolyte imbalances. It should not be used in long-term treatment of angle-closure glaucoma. Serious reactions, including Stevens-Johnson syndrome and blood disorders, have been reported. Discontinue use if hypersensitivity occurs.