Maraviroc
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
CCR5 Co-receptor Antagonist
Controlled Drug Substance
No
Maraviroc
Summary
Maraviroc is used to treat CCR5-tropic HIV-1 infection in adults and children weighing at least 2 kg. It's used in combination with other antiretroviral medications to help manage HIV infection and reduce the risk of developing AIDS and related illnesses.
Maraviroc works by blocking the CCR5 coreceptor on immune cells. This prevents the CCR5-tropic HIV-1 virus from entering and infecting these cells, thereby reducing the amount of virus in the blood and helping to maintain immune function.
For adults, the usual dose of Maraviroc is 150 mg, 300 mg, or 600 mg twice daily depending on interactions with other medications. For children weighing at least 2 kg, the dose is based on body weight and concomitant medications. Maraviroc can be taken with or without food.
Common side effects of Maraviroc include cough, runny nose, dizziness, diarrhea, and constipation. Serious adverse effects include hepatotoxicity, severe skin reactions, and cardiovascular events. If you experience any severe or persistent side effects, you should report them to your healthcare provider immediately.
Maraviroc carries a risk of hepatotoxicity and severe skin and hypersensitivity reactions. It is contraindicated in patients with severe renal impairment or end-stage renal disease who are taking potent CYP3A inhibitors or inducers. Patients should be monitored for liver function and signs of allergic reactions.
Indications and Purpose
How does Maraviroc work?
Maraviroc works by blocking the CCR5 receptor on the surface of immune cells. This prevents HIV-1 from entering and infecting these cells, thereby reducing the viral load in the body and helping to maintain immune function.
Is Maraviroc effective?
Maraviroc has been shown to effectively reduce HIV-1 viral load and increase CD4+ cell counts in clinical trials. It is used in combination with other antiretroviral medications to manage HIV-1 infection, helping to prevent the progression to AIDS.
What is Maraviroc?
Maraviroc is used to treat CCR5-tropic HIV-1 infection in combination with other antiretroviral medications. It works by blocking the CCR5 receptor on immune cells, preventing the virus from entering and infecting these cells. This helps reduce the viral load and increase CD4+ cell counts.
Directions for Use
For how long do I take Maraviroc?
Maraviroc is typically used as part of a long-term treatment plan for HIV-1 infection. The duration of use is determined by a healthcare provider based on individual patient needs and response to treatment.
How do I take Maraviroc?
Maraviroc can be taken with or without food. It is important to take it at the same times every day as prescribed by your doctor. There are no specific food restrictions, but always follow your healthcare provider's advice.
How long does it take for Maraviroc to start working?
Maraviroc begins to work within a few hours of taking the first dose, but it may take several weeks to see a significant reduction in viral load. Regular monitoring by a healthcare provider is necessary to assess its effectiveness.
How should I store Maraviroc?
Store Maraviroc at room temperature, away from excess heat and moisture. Keep it in its original container, tightly closed, and out of reach of children. Discard any unused oral solution 60 days after first opening the bottle.
What is the usual dose of Maraviroc?
For adults, the usual dose of Maraviroc is 150 mg, 300 mg, or 600 mg taken twice daily, depending on other medications being taken. For children weighing at least 2 kg, the dose is based on body weight and other medications, with specific dosing guidelines provided by a healthcare provider.
Warnings and Precautions
Can I take Maraviroc with other prescription drugs?
Maraviroc interacts with medications that affect CYP3A enzymes, such as certain antifungals, antibiotics, and antiretrovirals. These interactions can alter Maraviroc levels in the body, requiring dosage adjustments. Always inform your doctor of all medications you are taking.
Can Maraviroc be taken safely while breastfeeding?
Mothers with HIV-1 infection are advised not to breastfeed to prevent transmission of the virus to the infant. It is unknown if Maraviroc is excreted in human milk, so breastfeeding is not recommended while taking this medication.
Can Maraviroc be taken safely while pregnant?
There is limited data on the use of Maraviroc during pregnancy. It should only be used if the potential benefits justify the potential risks to the fetus. Pregnant women taking Maraviroc are encouraged to enroll in a pregnancy registry to monitor outcomes.
Is it safe to exercise while taking Maraviroc?
Maraviroc may cause dizziness or lightheadedness, which could affect your ability to exercise safely. If you experience these symptoms, it is advisable to avoid strenuous activities and consult your doctor for guidance.
Is Maraviroc safe for the elderly?
Elderly patients may have a higher risk of side effects due to age-related changes in liver and kidney function. Caution is advised, and dosage adjustments may be necessary. Regular monitoring by a healthcare provider is recommended.
Who should avoid taking Maraviroc?
Maraviroc can cause serious liver problems and severe allergic reactions. It is contraindicated in patients with severe renal impairment who are taking potent CYP3A inhibitors or inducers. Patients should be monitored for signs of liver damage and allergic reactions.
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