Lubiprostone
Constipation, Irritable Bowel Syndrome
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Chloride Channel Activator
Controlled Drug Substance
No
Lubiprostone
Summary
Lubiprostone is used to treat chronic idiopathic constipation, irritable bowel syndrome with constipation in women, and opioid-induced constipation.
Lubiprostone works by increasing fluid secretion in the intestines which helps to soften stools and promote bowel movements. This action alleviates symptoms like abdominal pain and bloating.
For adults, the usual dose of Lubiprostone is 24 mcg taken twice daily for chronic idiopathic constipation and opioid-induced constipation. For irritable bowel syndrome with constipation, the dose is 8 mcg twice daily.
Common side effects of Lubiprostone include nausea, diarrhea, and headache. Serious adverse effects can include severe diarrhea, shortness of breath, and chest tightness.
Lubiprostone is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction. Patients should be aware of the risk of severe diarrhea, syncope, and hypotension. If these occur, they should discontinue use and contact their healthcare provider immediately.
Indications and Purpose
How does Lubiprostone work?
Lubiprostone works by activating chloride channels in the intestines, which increases fluid secretion. This process helps soften stools and promotes bowel movements, providing relief from constipation. Think of it like adding water to a dry sponge, making it easier to move through the intestines. This medication is effective for conditions like chronic idiopathic constipation and irritable bowel syndrome with constipation. If you have questions about how Lubiprostone works, talk with your doctor.
Is Lubiprostone effective?
Lubiprostone is effective for treating chronic idiopathic constipation and irritable bowel syndrome with constipation. It works by increasing fluid secretion in the intestines, which helps ease bowel movements. Clinical studies show that Lubiprostone significantly improves stool consistency and frequency, providing relief from constipation symptoms. If you have questions about its effectiveness for your condition, discuss them with your doctor. They can provide guidance based on your specific health needs.
What is Lubiprostone?
Lubiprostone is a medication used to treat chronic idiopathic constipation and irritable bowel syndrome with constipation. It belongs to a class of drugs called chloride channel activators. Lubiprostone works by increasing fluid secretion in the intestines, which helps ease bowel movements. This medication is typically used when other treatments haven't worked. If you have questions about Lubiprostone, talk with your doctor for more information.
Directions for Use
For how long do I take Lubiprostone?
Lubiprostone is used for short-term treatment of constipation symptoms. The duration of use depends on your condition and how you respond to the medication. Your doctor will guide you on how long to take Lubiprostone based on your specific health needs. Always follow your doctor's instructions and talk with them before changing or stopping your treatment.
How do I dispose of Lubiprostone?
To dispose of Lubiprostone, take it to a drug take-back program or collection site at a pharmacy or hospital. This ensures safe disposal without harming people or the environment. If a take-back program isn't available, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away.
How do I take Lubiprostone?
Take Lubiprostone as prescribed by your doctor, usually twice daily with food to reduce nausea. Swallow the capsules whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not double up on doses. There are no specific dietary or beverage restrictions, but always follow your doctor's advice. If you have questions about taking Lubiprostone, consult your healthcare provider for personalized instructions.
How long does it take for Lubiprostone to start working?
Lubiprostone usually starts working within 24 hours, but it may take a few days to achieve its full effect. The time it takes to work can vary depending on individual factors like your overall health and the severity of your condition. If you don't notice improvement after a few days, talk with your doctor. They can help determine if Lubiprostone is working for you or if adjustments are needed.
How should I store Lubiprostone?
Store Lubiprostone at room temperature, away from moisture and light. Keep it in its original container with the lid tightly closed. Avoid storing it in humid places like bathrooms, as moisture can affect the medication's effectiveness. Always keep Lubiprostone out of reach of children to prevent accidental ingestion. Check the expiration date regularly and dispose of any unused or expired medication properly.
What is the usual dose of Lubiprostone?
The usual starting dose of Lubiprostone for adults is 24 micrograms taken twice daily with food. This helps manage conditions like chronic idiopathic constipation and irritable bowel syndrome with constipation. Dose adjustments may be necessary for special populations, such as the elderly or those with liver issues. Always follow your doctor's specific dosing instructions for your health needs. If you have questions about your dose, consult your healthcare provider.
Warnings and Precautions
Can I take Lubiprostone with other prescription drugs?
There are no major or moderate drug interactions specifically associated with Lubiprostone. However, always inform your doctor about all medications you are taking to avoid potential interactions. This includes prescription drugs, over-the-counter medications, and supplements. Your doctor can help ensure your treatment is safe and effective by considering all possible interactions.
Can Lubiprostone be taken safely while breastfeeding?
The safety of Lubiprostone while breastfeeding is not well-established. It's unclear if the medication passes into breast milk or affects the breastfed infant. If you're breastfeeding or planning to breastfeed, discuss your treatment options with your doctor. They can help determine the safest approach for you and your baby, considering the potential risks and benefits.
Can Lubiprostone be taken safely while pregnant?
The safety of Lubiprostone during pregnancy is not well-established. Limited data is available, and its use is generally not recommended unless the benefits outweigh the risks. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for your condition. They can help create a plan that protects both you and your baby.
Does Lubiprostone have adverse effects?
Adverse effects are unwanted reactions to a medication. With Lubiprostone, common adverse effects include nausea, diarrhea, and abdominal pain. These occur in more than 10% of users and are usually mild to moderate. Serious side effects are rare but can include severe diarrhea or allergic reactions. If you experience severe symptoms, contact your doctor immediately. Always inform your healthcare provider about any new or worsening symptoms while taking Lubiprostone to ensure safe and effective treatment.
Does Lubiprostone have any safety warnings?
Yes, Lubiprostone has safety warnings. It can cause nausea, diarrhea, and abdominal pain. These symptoms are usually mild but can be severe. If you experience severe symptoms, contact your doctor. Lubiprostone is not recommended for people with known or suspected bowel obstruction. If you have liver problems, your doctor may adjust your dose. Always follow your doctor's instructions and report any unusual symptoms. Not adhering to safety warnings can lead to complications, so it's important to use this medication as directed.
Is it safe to drink alcohol while taking Lubiprostone?
There are no well-established interactions between Lubiprostone and alcohol. However, alcohol can worsen side effects like nausea and diarrhea. It's best to limit alcohol consumption while taking this medication. If you choose to drink, do so in moderation and watch for any worsening symptoms. Talk with your doctor about alcohol use while taking Lubiprostone to get personalized advice based on your health situation.
Is it safe to exercise while taking Lubiprostone?
Yes, you can exercise while taking Lubiprostone. However, be aware that this medication can cause nausea and diarrhea, which might affect your exercise capacity. If you experience these symptoms, consider adjusting your workout intensity or duration. Stay hydrated and listen to your body. If you have concerns about exercising while on Lubiprostone, consult your doctor for personalized advice.
Is it safe to stop Lubiprostone?
Lubiprostone is usually used for symptomatic relief of constipation. Stopping it suddenly is generally safe, but your symptoms may return. There are no known withdrawal symptoms. However, always talk with your doctor before stopping any medication. They can provide guidance on managing your condition and suggest alternative treatments if needed. Your doctor will help ensure any changes to your medication are safe and effective for your health.
Is Lubiprostone addictive?
Lubiprostone is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. This medication works by increasing fluid secretion in the intestines to help with bowel movements. It doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for Lubiprostone or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Lubiprostone doesn't carry this risk.
Is Lubiprostone safe for the elderly?
The elderly may be more vulnerable to side effects from medications like Lubiprostone. While it is generally safe, older adults may experience more pronounced side effects such as nausea and diarrhea. It's important for elderly patients to be closely monitored by their healthcare provider while taking this medication. If you have concerns about using Lubiprostone as an older adult, discuss them with your doctor.
What are the most common side effects of Lubiprostone?
Side effects are unwanted reactions to a medication. Common side effects of Lubiprostone include nausea, diarrhea, and abdominal pain, affecting more than 10% of users. These symptoms are usually mild and may improve over time. If you experience new symptoms after starting Lubiprostone, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication to ensure your treatment remains safe and effective.
Who should avoid taking Lubiprostone?
Lubiprostone should not be used if you have a known or suspected bowel obstruction, as it can worsen the condition. This is an absolute contraindication. For people with severe diarrhea, caution is advised, and the medication should be used only if the benefits outweigh the risks. Always inform your doctor about your medical history before starting Lubiprostone. They can help determine if this medication is safe for you.
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