Lorlatinib
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Lorlatinib
Summary
Lorlatinib is used to treat certain types of lung cancer, specifically non-small cell lung cancer with specific genetic mutations, which are changes in the DNA of cancer cells that affect their growth.
Lorlatinib works by blocking specific proteins in cancer cells, known as kinases, which are involved in cell growth and division. This action helps slow or stop the growth of cancer cells.
The usual starting dose of Lorlatinib for adults is 100 mg taken once daily. It is taken orally, which means by mouth, and can be taken with or without food.
Common side effects of Lorlatinib include weight gain, mood changes, and high blood pressure, which is when the force of blood against artery walls is too high.
Lorlatinib can cause serious side effects like lung problems and heart issues. It is not recommended for people with certain heart conditions due to these risks.
Indications and Purpose
How does Lorlatinib work?
Lorlatinib works by blocking specific proteins in cancer cells, known as kinases, which are involved in cell growth and division. By inhibiting these proteins, Lorlatinib helps slow or stop the growth of cancer cells. Think of it like turning off a switch that controls cell growth. This action makes Lorlatinib effective in treating certain types of lung cancer with specific genetic mutations.
Is Lorlatinib effective?
Lorlatinib is effective in treating certain types of lung cancer. It works by targeting specific proteins in cancer cells, helping to slow or stop their growth. Clinical studies show that Lorlatinib can improve outcomes for patients with specific genetic mutations in their cancer. Your doctor will monitor your response to the medication through regular check-ups and tests to ensure it's working effectively for your condition.
What is Lorlatinib?
Lorlatinib is a medication used to treat certain types of lung cancer. It belongs to a class of drugs called kinase inhibitors, which work by blocking specific proteins in cancer cells to slow or stop their growth. Lorlatinib is primarily used for patients with specific genetic mutations in their cancer. It can be used alone or in combination with other therapies, depending on your doctor's recommendation.
Directions for Use
For how long do I take Lorlatinib?
Lorlatinib is usually a long-term medication for managing certain types of lung cancer. You'll typically take it every day as part of your ongoing treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Lorlatinib treatment.
How do I dispose of Lorlatinib?
Dispose of Lorlatinib by taking it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away.
How do I take Lorlatinib?
Take Lorlatinib exactly as your doctor prescribes. It's usually taken once daily, with or without food. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for Lorlatinib to start working?
Lorlatinib begins working in your body shortly after you take it, but the full therapeutic effects may take weeks to become noticeable. The time it takes to see results can vary based on individual factors like your overall health and the specific characteristics of your cancer. Regular check-ups and tests with your doctor will help monitor your response to the medication and adjust your treatment as needed.
How should I store Lorlatinib?
Store Lorlatinib at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Avoid storing it in humid places like bathrooms. Always keep Lorlatinib out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication. Follow your pharmacist's instructions for safe storage.
What is the usual dose of Lorlatinib?
The usual starting dose of Lorlatinib for adults is 100 mg once daily. Your doctor may adjust your dose based on your response to the medication and any side effects you experience. It's important to follow your doctor's specific dosing instructions for your personal health needs. Always consult your healthcare provider before making any changes to your medication regimen.
Warnings and Precautions
Can I take Lorlatinib with other prescription drugs?
Lorlatinib can interact with other medications, increasing the risk of side effects or reducing effectiveness. Major interactions include certain heart medications and drugs that affect liver enzymes. Always inform your doctor about all medications you're taking to avoid potential interactions. Your doctor can adjust your treatment plan to manage these risks and ensure Lorlatinib works effectively for you.
Can Lorlatinib be taken safely while breastfeeding?
Lorlatinib is not recommended while breastfeeding. We don't have much information about whether it passes into human breast milk, but it may pose risks to a nursing baby. If you're taking Lorlatinib and want to breastfeed, talk with your doctor about safer medication options. They can help you make informed decisions about your treatment and breastfeeding to ensure your baby's safety.
Can Lorlatinib be taken safely while pregnant?
Lorlatinib is not recommended during pregnancy due to potential risks to the unborn baby. Animal studies suggest it may harm fetal development. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby. Always inform your healthcare provider if you become pregnant while taking Lorlatinib.
Does Lorlatinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Lorlatinib can cause side effects like high blood pressure, weight gain, and mood changes. Serious effects include lung problems and heart issues. If you notice new or worsening symptoms, contact your doctor. They can help determine if these are related to Lorlatinib and suggest ways to manage them. Always report any concerning symptoms to your healthcare provider.
Does Lorlatinib have any safety warnings?
Yes, Lorlatinib has important safety warnings. It can cause serious side effects, including lung problems, high blood pressure, and heart issues. If you experience symptoms like shortness of breath, chest pain, or swelling in your legs, seek medical help immediately. Regular monitoring by your doctor is essential to manage these risks. Always follow your doctor's advice and report any new or worsening symptoms promptly.
Is it safe to drink alcohol while taking Lorlatinib?
It's best to avoid alcohol while taking Lorlatinib. Alcohol can increase the risk of side effects like dizziness and liver problems. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like nausea or dizziness. These symptoms could indicate a reaction and require medical attention. Talk with your doctor about alcohol use while taking Lorlatinib for personalized advice.
Is it safe to exercise while taking Lorlatinib?
You can exercise while taking Lorlatinib, but be mindful of how your body feels. Lorlatinib can cause dizziness or fatigue, which might affect your exercise capacity. To exercise safely, drink plenty of water and avoid strenuous activities if you feel unwell. Watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest. Consult your doctor if you have concerns.
Is it safe to stop Lorlatinib?
Stopping Lorlatinib suddenly can cause your condition to worsen. It's important to talk with your doctor before stopping this medication. They might suggest gradually reducing your dose or switching to a different treatment to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health. Always follow your healthcare provider's advice when considering changes to your medication regimen.
Is Lorlatinib addictive?
Lorlatinib is not considered addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Lorlatinib works by targeting specific proteins in cancer cells, and this mechanism doesn't affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, discuss them with your doctor, but Lorlatinib doesn't carry this risk.
Is Lorlatinib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Lorlatinib, such as high blood pressure and heart issues. It's important for older adults to have regular check-ups with their doctor to monitor for any adverse effects. Your doctor will consider your overall health and any other medications you're taking to ensure Lorlatinib is safe for you. Always follow your doctor's advice and report any new symptoms.
What are the most common side effects of Lorlatinib?
Side effects are unwanted reactions to a medication. Common side effects of Lorlatinib include weight gain, mood changes, and high blood pressure. These effects vary from person to person. If you notice new symptoms after starting Lorlatinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication. They can help determine if the symptoms are related to Lorlatinib.
Who should avoid taking Lorlatinib?
Don't take Lorlatinib if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Lorlatinib is not recommended for people with certain heart conditions due to the risk of heart problems. Always inform your doctor about your medical history and any other medications you're taking. They can help determine if Lorlatinib is safe for you and discuss any potential risks.
