Lorazepam
Partial Epilepsies, Depressive Disorder ... show more
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
Benzodiazepine
Controlled Drug Substance
YES

Lorazepam
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Click HereSummary
Lorazepam is used to treat conditions such as anxiety, insomnia, and seizures. It helps calm the brain and nervous system, providing quick relief from severe anxiety. However, it's not intended for everyday worries or long-term use.
Lorazepam works by attaching to special spots on brain cells called GABA receptors. This makes those brain cells less active, leading to a calming effect. It's like turning down the volume on a noisy brain. This results in reduced anxiety, better sleep, or cessation of seizures.
For anxiety, the typical dose is 2-3 mg daily in divided doses. For insomnia, a single dose of 2-4 mg at bedtime may be prescribed. The medicine can be taken with or without food. It should not be crushed or chewed, but swallowed whole.
Common side effects of Lorazepam include drowsiness, dizziness, weakness, and feeling unsteady. In rare cases, it may cause mood swings, irritability, depression, and decreased libido. It may also cause sleepiness and dizziness, making it harder to sleep well or drive.
Lorazepam is a strong medicine with serious risks. Mixing it with opioids can be deadly. It makes you sleepy and dizzy, so don't drive or use machinery. It's addictive and stopping it suddenly can be very dangerous. It can also make depression worse. Avoid alcohol and be cautious with caffeine and exercise.
Indications and Purpose
How does Lorazepam work?
Lorazepam is a medicine that calms anxiety. It works by attaching to special spots on brain cells called GABA receptors. This makes those brain cells less active, leading to a calming effect. It's like turning down the volume on a noisy brain.
How does one know if Lorazepam is working?
Symptoms such as reduced anxiety, better sleep, or cessation of seizures indicate that Lorazepam is effective.
Is Lorazepam effective?
Imagine your brain has tiny switches that control how calm or anxious you feel. Lorazepam works by turning down the "anxiety" switches. It does this by fitting into special spots on those switches, making them more effective at calming things down. This leads to a feeling of relaxation and less anxiety.
What is Lorazepam?
Lorazepam is a benzodiazepine medication used to treat anxiety, insomnia, and seizures. It works by calming the brain and nervous system.
What is Lorazepam used for?
Lorazepam helps calm anxiety quickly, but it's only for short-term use, like when anxiety is really bad. It's not for everyday worries. Doctors don't know for sure if it continues to help after a few months.
Directions for Use
For how long do I take Lorazepam?
We don't have enough solid research on how long anxiety lasts beyond four months. For quick anxiety relief, doctors sometimes prescribe lorazepam as needed. The amount and how long someone takes it depends on the individual.
How do I take Lorazepam?
Take your LOREEV XR medicine once a day in the morning. You can take it with or without food. Don't crush or chew the capsules; swallow them whole, or if you can't, open the capsule, sprinkle the medicine on a spoonful of applesauce, and eat it right away. Don't save any sprinkled medicine for later.
How long does it take for Lorazepam to start working?
Imagine you take a pill. The medicine in that pill doesn't go everywhere in your body instantly. It takes time to be absorbed into your bloodstream. "Peak plasma concentration" means the highest amount of medicine is in your blood. This happens about two hours after you take the pill because that's how long it takes for your body to absorb most of it.
How should I store Lorazepam?
Keep the liquid Lorazepam in the fridge and away from light. Use it within 3 months of opening. The pills and capsules can be kept at room temperature. Keep all medicine tightly closed and away from kids.
What is the usual dose of Lorazepam?
The dose depends on the condition being treated. For anxiety, the typical dose is 2-3 mg daily in divided doses. For insomnia, a single dose of 2-4 mg at bedtime may be prescribed
Warnings and Precautions
Can I take Lorazepam with other prescription drugs?
Lorazepam may interact with:
- Other sedatives or opioids (increased risk of respiratory depression)
- Antidepressants
- Anticonvulsants
- AlcoholAlways inform your doctor about other medications you are taking.
Can I take Lorazepam with vitamins or supplements?
Some supplements, like valerian root or melatonin, may amplify Lorazepam’s sedative effects. Discuss any supplements with your doctor.
Can Lorazepam be taken safely while breastfeeding?
Lorazepam is a medicine that can make you sleepy. If you're breastfeeding and take lorazepam, the medicine can pass into your breast milk and make your baby sleepy and sluggish, affecting their feeding and growth. We don't know for sure how lorazepam affects your milk supply, but because of the risk to the baby, breastfeeding isn't advised while you're taking it.
Can Lorazepam be taken safely while pregnant?
Taking Lorazepam late in pregnancy might make a newborn sleepy or go through withdrawal. Studies in people haven't shown a strong link to major birth defects. However, high doses harmed animals in studies. There's a natural risk of birth defects and miscarriage anyway (2-4% and 15-20%, respectively). Doctors are keeping track of pregnancies where Lorazepam is used.
Is it safe to drink alcohol while taking Lorazepam?
Drinking alcohol while taking LOREEV XR can make the medicine work differently and might be unsafe. Studies show that alcohol significantly speeds up how quickly the medicine is released into your body. This could mean you get too much medicine too fast, which isn't good. It's best to avoid alcohol completely while you're on this medication.
Is it safe to exercise while taking Lorazepam?
Light to moderate exercise is safe, but avoid activities requiring high alertness or coordination. Be cautious if you feel drowsy.
Is Lorazepam safe for the elderly?
Older adults often need smaller amounts of medicine than younger people because their bodies process drugs differently. They may feel sleepy or unsteady more easily, so it's best to start with the smallest dose that works. If the person has liver or kidney problems, even smaller doses might be needed.
Who should avoid taking Lorazepam?
Lorazepam is a strong medicine with serious risks. Mixing it with opioid painkillers can be deadly. It makes you sleepy and dizzy, so don't drive or use machinery. It's addictive, and stopping it suddenly can be very dangerous. It can also make depression worse. Common side effects include feeling sleepy, dizzy, weak, and unsteady.