Lomustine
Hodgkin Disease, Non-Hodgkin Lymphoma ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Alkylating Drug
Controlled Drug Substance
No
Lomustine
Summary
Lomustine is used to treat certain types of brain tumors and Hodgkin's lymphoma that have not responded to other treatments.
Lomustine works by alkylating DNA and RNA, disrupting the growth and replication of cancer cells. It may also inhibit key enzymatic processes, contributing to its anticancer effects.
Lomustine is usually taken as a single dose every 6 weeks. For adults, the recommended dose is 130 mg/m. For children, the dosage is based on body surface area. It is taken orally, and the capsules should be swallowed whole.
Common side effects of Lomustine include nausea, vomiting, loss of appetite, and fatigue. Serious adverse effects can include myelosuppression, pulmonary toxicity, hepatotoxicity, and nephrotoxicity.
Lomustine can cause severe myelosuppression and is contraindicated in severe bone marrow depression and severe renal impairment. It can harm a fetus and is contraindicated during pregnancy. It can also cause serious reactions in breastfed infants, so breastfeeding is not recommended during treatment and for 2 weeks after the final dose.
Indications and Purpose
How does Lomustine work?
Lomustine works by alkylating DNA and RNA, which disrupts the growth and replication of cancer cells. It may also inhibit key enzymatic processes by carbamoylation of amino acids in proteins, contributing to its anti-cancer effects.
Is Lomustine effective?
Lomustine is used to treat certain types of brain tumors and Hodgkin's lymphoma that have not improved with other treatments. It works by slowing or stopping the growth of cancer cells. Its effectiveness is supported by clinical use and studies, but individual responses can vary.
What is Lomustine?
Lomustine is used to treat certain brain tumors and Hodgkin's lymphoma that have not responded to other treatments. It belongs to a class of medications called alkylating agents, which work by slowing or stopping the growth of cancer cells. Regular monitoring is essential to manage potential side effects.
Directions for Use
For how long do I take Lomustine?
Lomustine is usually taken as a single dose every 6 weeks. The duration of treatment depends on the individual's response to the medication and the specific condition being treated. Your doctor will determine the appropriate length of treatment based on your medical needs.
How do I take Lomustine?
Lomustine should be taken as a single dose every 6 weeks on an empty stomach. Swallow the capsules whole without splitting, chewing, or crushing them. There are no specific food restrictions, but always follow your doctor's instructions regarding diet and medication use.
How should I store Lomustine?
Store Lomustine in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children. Do not store it in the bathroom. Dispose of unneeded medication through a take-back program, not by flushing it down the toilet.
What is the usual dose of Lomustine?
Lomustine is typically administered as a single oral dose every 6 weeks. For adults, the recommended dose is 130 mg/m². For children, the dosage is also based on body surface area, similar to adults, but specific pediatric dosing should be determined by a healthcare provider. Always follow the doctor's prescription and guidance.
Warnings and Precautions
Can I take Lomustine with other prescription drugs?
Lomustine may interact with other myelosuppressive drugs, increasing the risk of bone marrow suppression. It can also interact with medications like theophylline and cimetidine, potentially enhancing bone marrow toxicity. Always inform your doctor about all medications and supplements you are taking.
Can Lomustine be taken safely while breastfeeding?
Lomustine is contraindicated during breastfeeding due to the potential for serious adverse reactions in breastfed infants. Women should not breastfeed during treatment and for 2 weeks after the final dose. Consult your doctor for personalized advice.
Can Lomustine be taken safely while pregnant?
Lomustine can cause fetal harm and is contraindicated during pregnancy. Women of childbearing potential should use effective contraception during treatment and for at least 2 weeks after the final dose. If pregnancy occurs, consult your doctor immediately. There is no strong evidence from human studies, but animal studies show potential risks.
Is it safe to exercise while taking Lomustine?
Lomustine can cause fatigue and weakness, which may limit your ability to exercise. If you experience these symptoms, it is important to rest and avoid strenuous activities. Consult your doctor for personalized advice on physical activity during treatment.
Is Lomustine safe for the elderly?
There is no specific data available for the elderly population regarding Lomustine use. However, elderly patients are more likely to have decreased renal function, which may increase the risk of toxic reactions. Dose selection should be cautious, and renal function should be monitored closely.
Who should avoid taking Lomustine?
Lomustine can cause severe myelosuppression, increasing the risk of infection and bleeding. It may also cause pulmonary toxicity, secondary malignancies, hepatotoxicity, and nephrotoxicity. It is contraindicated in severe bone marrow depression and severe renal impairment. Regular monitoring of blood counts, liver, and kidney function is essential.
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