Letrozole
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
No
Pharmaceutical Class
Aromatase Inhibitor
Controlled Drug Substance
No
letrozole
Summary
Letrozole is used to treat hormone receptor-positive breast cancer, which is a type of cancer that grows in response to estrogen, in postmenopausal women. It is often used as a first-line treatment or after surgery to prevent the cancer from returning.
Letrozole works by inhibiting aromatase, which is an enzyme that converts androgens into estrogen. By blocking this enzyme, Letrozole reduces estrogen levels, which can slow or stop the growth of hormone receptor-positive breast cancer.
The usual starting dose of Letrozole for adults is 2.5 mg once daily. It is taken as a pill, with or without food, at the same time each day. Swallow the tablet whole without crushing or chewing it.
Common side effects of Letrozole include hot flashes, which are sudden feelings of warmth, joint pain, and fatigue, which is a feeling of tiredness. These effects occur in more than 10% of users.
Letrozole can cause bone thinning, which increases fracture risk, and liver problems. It should not be used in premenopausal women or during pregnancy, as it can harm the fetus. Regular monitoring of bone density and liver function is recommended.
Indications and Purpose
How does Letrozole work?
Letrozole works by inhibiting an enzyme called aromatase, which is responsible for converting androgens into estrogen in the body. By blocking this enzyme, Letrozole reduces estrogen levels, which can slow or stop the growth of hormone receptor-positive breast cancer. Think of it like turning off a faucet to stop the flow of water. This reduction in estrogen helps prevent cancer cells from receiving the signals they need to grow and multiply.
Is Letrozole effective?
Yes, Letrozole is effective in treating hormone receptor-positive breast cancer in postmenopausal women. It works by reducing estrogen levels, which can slow or stop the growth of certain breast cancers. Clinical studies show that Letrozole significantly improves survival rates and reduces the risk of cancer recurrence. It is often used as a first-line treatment or after surgery to prevent cancer from returning. Letrozole's effectiveness is well-supported by research and clinical experience.
What is Letrozole?
Letrozole is a medication used to treat hormone receptor-positive breast cancer in postmenopausal women. It belongs to a class of drugs called aromatase inhibitors, which work by reducing estrogen levels in the body. Estrogen can promote the growth of certain types of breast cancer, so lowering its levels can help slow or stop cancer growth. Letrozole is often used as a first-line treatment or after surgery to prevent cancer from returning.
Directions for Use
For how long do I take Letrozole?
Letrozole is usually taken long-term for breast cancer treatment. The duration depends on your specific condition and response to treatment. Some patients may take it for several years to reduce the risk of cancer recurrence. Your doctor will determine the appropriate length of treatment based on your individual needs and health status. Always follow your doctor's instructions and discuss any concerns about the duration of your Letrozole treatment with them.
How do I dispose of Letrozole?
To dispose of Letrozole, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If a take-back program is not available, you can throw Letrozole in the trash at home. First, mix it with something undesirable, like used coffee grounds, seal it in a plastic bag, and then throw it away. Always follow local guidelines for medication disposal.
How do I take Letrozole?
Letrozole is usually taken as a once-daily pill. You can take it with or without food, but try to take it at the same time each day. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Always follow your doctor's specific instructions regarding your Letrozole treatment.
How long does it take for Letrozole to start working?
Letrozole begins working in your body shortly after you take it, but the full therapeutic effects may take several weeks to become noticeable. The time it takes to see results can vary depending on individual factors like your overall health and the specific condition being treated. Regular follow-up appointments with your doctor will help monitor your progress and determine how well Letrozole is working for you. Always take it as prescribed for the best results.
How should I store Letrozole?
Store Letrozole tablets at room temperature, away from moisture and light. Keep them in their original packaging until you're ready to take them. Avoid storing Letrozole in humid places like bathrooms, as moisture can affect the medication's effectiveness. Always keep Letrozole out of reach of children to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication according to local guidelines.
What is the usual dose of Letrozole?
The usual starting dose of Letrozole for adults is 2.5 mg once daily. This dose is typically taken at the same time each day, with or without food. Dose adjustments are not commonly needed, but your doctor may adjust your dose based on your response to the treatment. Letrozole is not recommended for use in children. Elderly patients usually take the same dose as younger adults, but they should be monitored closely for side effects.
Warnings and Precautions
Can I take Letrozole with other prescription drugs?
Letrozole can interact with certain medications, which may increase the risk of side effects or reduce its effectiveness. For example, combining Letrozole with tamoxifen, another breast cancer medication, can decrease Letrozole's effectiveness. Always inform your doctor about all medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions. Your doctor can help manage any interactions and adjust your treatment plan as needed to ensure safe and effective therapy.
Can Letrozole be taken safely while breastfeeding?
Letrozole is not recommended while breastfeeding. There is limited information on whether Letrozole passes into breast milk, but it could potentially affect the nursing infant. Letrozole reduces estrogen levels, which might impact milk production. If you are breastfeeding or planning to breastfeed, talk with your doctor about safer medication options. They can help you choose a treatment that allows you to nurse your baby safely while managing your health condition.
Can Letrozole be taken safely while pregnant?
Letrozole is not safe to use during pregnancy. It can harm the developing fetus and is contraindicated for pregnant women. Letrozole works by reducing estrogen levels, which can interfere with fetal development. If you are pregnant or planning to become pregnant, talk with your doctor about alternative treatments. It's important to use effective contraception while taking Letrozole to prevent pregnancy and protect the health of both mother and baby.
Does Letrozole have adverse effects?
Adverse effects are unwanted reactions to a medication. Letrozole can cause hot flashes, joint pain, and fatigue, which are common side effects. These occur in more than 10% of users. Serious adverse effects include bone thinning and liver problems, which require medical attention. If you notice any new or worsening symptoms while taking Letrozole, contact your doctor. They can help determine if these symptoms are related to the medication and suggest appropriate management strategies.
Does Letrozole have any safety warnings?
Yes, Letrozole has important safety warnings. It can cause bone thinning or osteoporosis, which increases the risk of fractures. Regular bone density monitoring is recommended. Letrozole may also cause liver problems, so liver function tests are advised. If you experience symptoms like jaundice, which is yellowing of the skin or eyes, seek medical attention. Not adhering to these warnings can lead to serious health issues. Always follow your doctor's advice and report any unusual symptoms.
Is it safe to drink alcohol while taking Letrozole?
It's best to limit alcohol consumption while taking Letrozole. Alcohol can increase the risk of side effects like dizziness and liver problems. Letrozole is metabolized in the liver, and alcohol can add extra strain. If you choose to drink, do so in moderation and watch for any warning signs like nausea or dizziness. Talk with your doctor about alcohol use while taking Letrozole to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Letrozole?
Yes, you can exercise while taking Letrozole, but be mindful of your body's response. Letrozole can cause joint pain or fatigue, which might affect your exercise capacity. Start with low-impact activities and gradually increase intensity as tolerated. Stay hydrated and listen to your body. If you experience unusual fatigue or joint pain, slow down or rest. Consult your doctor if you have concerns about exercising while on Letrozole, especially if you notice any new symptoms.
Is it safe to stop Letrozole?
Letrozole is usually taken long-term for breast cancer treatment. Stopping it suddenly can increase the risk of cancer recurrence. Always talk with your doctor before stopping Letrozole. They may suggest a gradual reduction or an alternative treatment to ensure your condition remains under control. Your doctor will help you make any medication changes safely to protect your health and prevent any potential withdrawal symptoms or complications.
Is Letrozole addictive?
No, Letrozole is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Letrozole works by blocking estrogen production, which is a hormone involved in certain types of breast cancer. This mechanism does not affect brain chemistry in ways that could lead to addiction. You won't experience cravings for Letrozole or feel compelled to take more than prescribed. If you have concerns about medication dependence, Letrozole does not carry this risk.
Is Letrozole safe for the elderly?
Letrozole is generally safe for elderly patients, but they may be more vulnerable to certain side effects like bone thinning and joint pain. The elderly often have other health conditions or take multiple medications, which can increase the risk of interactions or side effects. Regular monitoring of bone density and liver function is recommended. Always consult your doctor about any concerns or conditions that might affect the use of Letrozole in elderly patients to ensure safe and effective treatment.
What are the most common side effects of Letrozole?
Side effects are unwanted reactions to a medication. Common side effects of Letrozole include hot flashes, joint pain, and fatigue. These occur in more than 10% of users. Some people may also experience nausea or dizziness. If you notice new symptoms after starting Letrozole, they might be temporary or unrelated to the medication. It's important to talk with your doctor before stopping any medication, as they can help determine the cause of your symptoms and provide guidance.
Who should avoid taking Letrozole?
Letrozole should not be used in premenopausal women or during pregnancy, as it can harm the developing fetus. It is also contraindicated in individuals with known hypersensitivity to Letrozole or any of its ingredients. Caution is needed in patients with severe liver impairment, as Letrozole is metabolized in the liver. Always consult your doctor about any concerns or conditions that might affect the use of Letrozole to ensure safe and effective treatment.
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