Letermovir
Cytomegalovirus Infections
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Cytomegalovirus DNA Terminase Complex Inhibitor
Controlled Drug Substance
No
Summary
Letermovir is used to prevent cytomegalovirus (CMV) infection, which is a virus that can cause serious illness, in patients who have received a stem cell transplant. It is particularly important for those with weakened immune systems.
Letermovir works by inhibiting a viral enzyme called the CMV DNA terminase complex, which is essential for the virus to multiply. By blocking this enzyme, it prevents the virus from replicating, reducing the risk of infection.
The usual starting dose of letermovir for adults is 480 mg taken once daily, with or without food. It is important to follow your doctor's instructions on the exact timing and dosage.
Common side effects of letermovir include nausea and diarrhea, which are usually mild and temporary. If you notice any new or worsening symptoms, contact your doctor.
Letermovir can cause liver problems, so regular liver function tests are recommended. It is not recommended for patients with severe liver problems. Inform your doctor about all medications you take to avoid potential interactions.
Indications and Purpose
How does letermovir work?
Letermovir works by inhibiting a viral enzyme called the CMV DNA terminase complex. This enzyme is essential for the virus to multiply. By blocking this enzyme, letermovir prevents the virus from replicating, reducing the risk of infection. Think of it like stopping a copy machine from making more copies. This action helps protect patients who have received a stem cell transplant from developing cytomegalovirus (CMV) infection.
Is letermovir effective?
Letermovir is effective in preventing cytomegalovirus (CMV) infection in patients who have received a stem cell transplant. Clinical studies show that letermovir significantly reduces the risk of CMV infection compared to placebo. This medication works by inhibiting a viral enzyme, which helps prevent the virus from multiplying. Letermovir is an important option for patients at high risk of CMV infection.
What is letermovir?
Letermovir is an antiviral medication used to prevent cytomegalovirus (CMV) infection in patients who have received a stem cell transplant. It belongs to a class of drugs called CMV DNA terminase complex inhibitors. Letermovir works by inhibiting a viral enzyme, which helps prevent the virus from multiplying. It's an important option for patients at high risk of CMV infection.
Directions for Use
For how long do I take letermovir?
Letermovir is usually taken for a specific duration to prevent cytomegalovirus (CMV) infection in patients who have received a stem cell transplant. The usual duration of use is around 100 days, but your doctor will determine the exact length based on your health needs. Always follow your doctor's instructions and don't stop taking letermovir without medical advice.
How do I dispose of letermovir?
If you can, bring unused letermovir to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take letermovir?
Letermovir is usually taken once daily, with or without food. It's important to follow your doctor's instructions on the exact timing and dosage. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for letermovir to start working?
Letermovir starts working soon after you take it, but you may not notice its effects immediately. It's used to prevent cytomegalovirus (CMV) infection, so the goal is to avoid developing the infection. Your doctor will monitor your health with regular blood tests to check for the presence of the virus. The full benefits of letermovir may take time to become apparent.
How should I store letermovir?
Store letermovir at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. Always keep letermovir out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of letermovir?
The usual starting dose of letermovir for adults is 480 mg once daily. Your doctor may adjust the dose based on your specific health needs. It's important to follow your doctor's dosing instructions carefully. Letermovir is not typically used in children, and elderly patients may require special monitoring. Always consult your doctor for personalized dosing advice.
Warnings and Precautions
Can I take letermovir with other prescription drugs?
Letermovir can interact with certain medications, increasing the risk of side effects or reducing effectiveness. It's important to inform your doctor about all the medicines you take, including over-the-counter drugs and supplements. Your doctor can help manage potential interactions and adjust your treatment plan as needed.
Can letermovir be taken safely while breastfeeding?
The safety of letermovir while breastfeeding is not well-established. It's unclear if this medication passes into breast milk. If you're breastfeeding or planning to breastfeed, talk with your doctor about the safest options for you and your baby. Your doctor can help determine the best treatment plan for your situation.
Can letermovir be taken safely while pregnant?
The safety of letermovir during pregnancy is not well-established. There is limited information on its use in pregnant women. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your health. Your doctor can help create a treatment plan that protects both you and your baby.
Does letermovir have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of letermovir include nausea and diarrhea. These effects are usually mild. Serious side effects are rare but can include liver problems. If you notice any new or worsening symptoms, contact your doctor. They can help determine if these symptoms are related to letermovir and suggest appropriate actions.
Does letermovir have any safety warnings?
Letermovir has important safety warnings. It can cause liver problems, so regular liver function tests are recommended. If you experience symptoms like yellowing of the skin or eyes, dark urine, or severe fatigue, contact your doctor immediately. Letermovir can also interact with other medications, so inform your doctor about all the medicines you take. Not adhering to these warnings can lead to serious health issues.
Is it safe to drink alcohol while taking letermovir?
It's best to avoid alcohol while taking letermovir. Alcohol can increase the risk of liver problems, which is a concern with letermovir. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like nausea or fatigue. Talk with your doctor about alcohol use while taking letermovir to get personalized advice.
Is it safe to exercise while taking letermovir?
You can exercise while taking letermovir, but keep a few things in mind. Letermovir can cause mild side effects like nausea or fatigue, which might affect your exercise capacity. To exercise safely, listen to your body and rest if you feel unwell. Most people can maintain their regular exercise routine while taking letermovir, but check with your doctor if you have concerns.
Is it safe to stop letermovir?
Letermovir is usually used for a specific duration to prevent viral infections. Stopping it suddenly without medical advice can increase the risk of infection. Always talk with your doctor before stopping letermovir. They might suggest a safe way to discontinue the medication or switch to another treatment to protect your health.
Is letermovir addictive?
Letermovir is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Letermovir works by inhibiting a viral enzyme, which doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is letermovir safe for the elderly?
Elderly patients may be more vulnerable to side effects of letermovir, such as liver problems. It's important for elderly patients to have regular check-ups and liver function tests while taking this medication. Your doctor will monitor your health closely to ensure letermovir is safe and effective for you.
What are the most common side effects of letermovir?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of letermovir include nausea and diarrhea. These effects are usually mild and temporary. If you notice new symptoms after starting letermovir, they might be unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking letermovir?
Don't take letermovir if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Letermovir is not recommended for patients with severe liver problems. Always inform your doctor about your medical history and any other medications you are taking to avoid potential interactions and ensure safe use.
