Lefamulin
Bacterial Pneumonia
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Pleuromutilin Antibacterial
Controlled Drug Substance
No
lefamulin
Summary
Lefamulin is used to treat community-acquired bacterial pneumonia, which is a lung infection caused by bacteria that you catch outside of a hospital setting.
Lefamulin works by inhibiting bacterial protein synthesis, which means it stops bacteria from making proteins they need to grow and multiply.
The usual dose for adults is 600 mg every 12 hours for 5 to 7 days. It is taken as a pill, which means you swallow it with water.
Common side effects include diarrhea, nausea, and vomiting, which are stomach-related issues that usually go away on their own.
Lefamulin can cause QT prolongation, which is a heart rhythm problem. Avoid it if you have a history of this condition or are taking other QT-prolonging drugs.
Indications and Purpose
How does Lefamulin work?
Lefamulin works by inhibiting bacterial protein synthesis, which stops bacteria from growing. Think of it like turning off a machine that makes parts for a factory. Without the parts, the factory can't produce anything. This action helps clear bacterial infections like pneumonia. Always take Lefamulin as prescribed by your doctor.
Is Lefamulin effective?
Lefamulin is effective in treating community-acquired bacterial pneumonia. It works by inhibiting bacterial protein synthesis, which stops bacteria from growing. Clinical studies show Lefamulin is effective in clearing infections and improving symptoms. Always take Lefamulin as prescribed by your doctor to ensure the best results.
What is Lefamulin?
Lefamulin is an antibiotic used to treat community-acquired bacterial pneumonia. It belongs to the pleuromutilin class of antibiotics and works by inhibiting bacterial protein synthesis, which stops bacteria from growing. Lefamulin is typically used when other antibiotics are not suitable or have not worked. Always take Lefamulin as prescribed by your doctor.
Directions for Use
For how long do I take Lefamulin?
Lefamulin is usually prescribed for short-term treatment of acute infections like pneumonia. The typical duration is 5 to 7 days, but always follow your doctor's specific instructions. Completing the full course of treatment is important to ensure the infection is fully cleared. Consult your doctor for any questions about your treatment duration.
How do I dispose of Lefamulin?
To dispose of Lefamulin, take it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away. This helps prevent harm to people and the environment.
How do I take Lefamulin?
Lefamulin is usually taken as a pill, either once or twice daily, depending on your doctor's instructions. You can take it with or without food. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific advice about how to take this medication.
How long does it take for Lefamulin to start working?
Lefamulin starts working shortly after you take it, but you may not notice all the benefits right away. Symptoms like fever and cough should improve within a few days. The full therapeutic effect may take the entire course of treatment. Always take Lefamulin as prescribed for the best results.
How should I store Lefamulin?
Store Lefamulin at room temperature, away from moisture and light. Keep it in a tightly closed container. Do not store it in humid places like bathrooms. Always store Lefamulin out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Lefamulin?
The usual dose of Lefamulin for adults is 600 mg every 12 hours for 5 to 7 days. This medication is typically used to treat pneumonia. Always follow your doctor's specific dosing instructions for your personal health needs. If you have any questions about your dose, consult your healthcare provider.
Warnings and Precautions
Can I take Lefamulin with other prescription drugs?
Lefamulin can interact with drugs that prolong the QT interval, which is a heart rhythm condition. This increases the risk of serious heart problems. Avoid using Lefamulin with other QT-prolonging drugs. Always inform your doctor about all medications you are taking to avoid interactions and ensure safe treatment.
Can Lefamulin be taken safely while breastfeeding?
Lefamulin is not recommended while breastfeeding. It's unclear if this medication passes into human breast milk. If you're taking Lefamulin and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Lefamulin be taken safely while pregnant?
Lefamulin is not recommended during pregnancy unless absolutely necessary. There is limited information on its safety in pregnant women. Animal studies have shown some risk to the fetus. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for your condition.
Does Lefamulin have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Lefamulin include diarrhea, nausea, and vomiting. These effects are usually mild. Serious side effects can include QT prolongation, which is a heart rhythm condition. If you experience severe side effects, contact your doctor immediately. Always inform your healthcare provider about any new or worsening symptoms.
Does Lefamulin have any safety warnings?
Lefamulin has important safety warnings. It can cause QT prolongation, which is a heart rhythm condition that can lead to serious irregular heartbeats. Avoid using Lefamulin with other drugs that prolong the QT interval. If you experience symptoms like dizziness or fainting, seek medical help. Always inform your doctor about all medications you are taking to avoid interactions.
Is it safe to drink alcohol while taking Lefamulin?
It's best to avoid alcohol while taking Lefamulin. Alcohol can increase the risk of side effects like dizziness and nausea. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like dizziness or nausea. Talk with your doctor about alcohol use while taking Lefamulin.
Is it safe to exercise while taking Lefamulin?
You can exercise while taking Lefamulin, but be cautious. This medication can cause dizziness or nausea, which might affect your ability to exercise. To exercise safely, drink plenty of water and watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest.
Is it safe to stop Lefamulin?
Lefamulin is usually prescribed for short-term use to treat infections like pneumonia. It's important to complete the full course of treatment to ensure the infection is fully cleared. Stopping the medication early can lead to a return of the infection or resistance. Always talk with your doctor before stopping Lefamulin.
Is Lefamulin addictive?
Lefamulin is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Lefamulin works by inhibiting bacterial protein synthesis, which doesn't affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that Lefamulin doesn't carry this risk.
Is Lefamulin safe for the elderly?
Elderly patients may be more vulnerable to side effects of Lefamulin, such as QT prolongation, which is a heart rhythm condition. They may also have other health conditions that require careful monitoring. Always consult your doctor about the risks and benefits of Lefamulin if you are elderly or caring for an elderly person.
What are the most common side effects of Lefamulin?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Lefamulin include diarrhea, nausea, and vomiting. These effects are usually mild and temporary. If you notice new symptoms after starting Lefamulin, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Lefamulin?
Lefamulin should not be used if you have a known allergy to it or its ingredients. It is also contraindicated in patients with a history of QT prolongation, which is a heart rhythm condition. Use caution if you have liver problems or are taking other medications that affect the heart. Always consult your doctor about these concerns.
