Larotrectinib
Neoplasm Metastasis
.svg)
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
larotrectinib
Summary
Larotrectinib is used to treat certain cancers with specific genetic mutations called NTRK gene fusions, which are changes in the DNA that can cause cancer cells to grow. It is effective for various solid tumors, which are abnormal masses of tissue, regardless of their location in the body.
Larotrectinib works by blocking TRK proteins, which are involved in the growth of cancer cells. By stopping these proteins, it helps prevent tumors, which are abnormal growths of tissue, from growing. This action makes it effective for treating cancers with specific genetic mutations.
For adults, the usual dose of Larotrectinib is 100 mg taken twice daily. For children, the dose is based on body surface area, which is a measure of body size, and should be determined by a healthcare provider. It is taken orally, which means by mouth, with or without food.
Common side effects of Larotrectinib include fatigue, which is extreme tiredness, dizziness, which is feeling lightheaded, and nausea, which is feeling sick to the stomach. These effects can vary from person to person, and not everyone will experience them.
Larotrectinib can cause liver problems, so regular liver function tests are recommended. It may also cause dizziness, so be cautious when driving. Do not take it if you're allergic to it or its ingredients. Always consult your doctor about any concerns before starting Larotrectinib.
Indications and Purpose
How does Larotrectinib work?
Larotrectinib works by blocking TRK proteins, which are involved in the growth of cancer cells. Think of it like turning off a switch that allows cancer cells to grow. By blocking these proteins, Larotrectinib helps stop the growth of tumors. This makes it effective for treating cancers with specific genetic mutations.
Is Larotrectinib effective?
Yes, Larotrectinib is effective for treating certain cancers with specific genetic mutations. It works by targeting proteins in cancer cells, helping to stop their growth. Clinical studies show that Larotrectinib can shrink tumors in patients with these mutations, improving health outcomes. Your doctor will monitor your progress to ensure the medication is working effectively for your condition.
What is Larotrectinib?
Larotrectinib is a medication used to treat certain cancers with specific genetic mutations. It belongs to a class of drugs called TRK inhibitors, which work by blocking proteins that help cancer cells grow. Larotrectinib is used to treat solid tumors in both adults and children, regardless of the tumor's location in the body.
Directions for Use
For how long do I take Larotrectinib?
Larotrectinib is usually taken as a long-term treatment for certain cancers with specific genetic mutations. The duration of use depends on your response to the medication and your doctor's recommendations. Always talk with your doctor before changing or stopping your Larotrectinib treatment.
How do I dispose of Larotrectinib?
To dispose of Larotrectinib, bring unused medicine to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Larotrectinib?
Take Larotrectinib exactly as your doctor prescribes. It's usually taken twice daily, with or without food. Swallow the capsules whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific instructions regarding food, beverages, and missed doses while taking Larotrectinib.
How long does it take for Larotrectinib to start working?
Larotrectinib begins working shortly after you start taking it, but the time to see full effects can vary. Some patients notice improvements in symptoms within weeks, while others may take longer. The time it takes to work can depend on factors like your overall health and the specific cancer being treated. Follow your doctor's instructions for the best results.
How should I store Larotrectinib?
Store Larotrectinib at room temperature, away from moisture and light. Keep it in a tightly closed container. Avoid storing it in humid places like bathrooms. Always keep Larotrectinib out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Larotrectinib?
The usual starting dose of Larotrectinib for adults is 100 mg taken twice daily. This dose can be adjusted based on your doctor's recommendations and your response to the treatment. For children, the dose is based on body surface area and should be determined by a healthcare provider. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can I take Larotrectinib with other prescription drugs?
Larotrectinib can interact with certain medications, increasing the risk of side effects or reducing effectiveness. It's important to inform your doctor about all medications you're taking, including over-the-counter drugs and supplements. Your doctor can help manage potential interactions and adjust your treatment plan as needed.
Can Larotrectinib be taken safely while breastfeeding?
The safety of Larotrectinib while breastfeeding is not well-established. It's unclear if the medication passes into breast milk. If you're breastfeeding or planning to breastfeed, talk with your doctor about safer medication options. They can help you make informed decisions to protect your baby's health.
Can Larotrectinib be taken safely while pregnant?
The safety of Larotrectinib during pregnancy is not well-established. Animal studies suggest potential risks, but human data is limited. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options. They can help create a plan that protects both you and your baby.
Does Larotrectinib have adverse effects?
Adverse effects are unwanted reactions to a medication. With Larotrectinib, common adverse effects include fatigue, dizziness, and nausea. These effects vary from person to person. Serious adverse effects can include liver problems and neurological issues. If you experience any new or worsening symptoms while taking Larotrectinib, contact your doctor. They can help determine if these symptoms are related to the medication and recommend appropriate action.
Does Larotrectinib have any safety warnings?
Yes, Larotrectinib has important safety warnings. It can cause liver problems, so regular liver function tests are recommended. Signs of liver issues include yellowing of the skin or eyes, dark urine, or stomach pain. If you experience these symptoms, contact your doctor immediately. Larotrectinib may also cause dizziness, so be cautious when driving or operating machinery. Always follow your doctor's advice and report any unusual symptoms.
Is it safe to drink alcohol while taking Larotrectinib?
It's best to avoid alcohol while taking Larotrectinib. Alcohol can increase the risk of liver problems, which is a concern with this medication. If you choose to drink occasionally, limit your alcohol intake and watch for symptoms like nausea or stomach pain. Talk with your doctor about alcohol use while taking Larotrectinib for personalized advice.
Is it safe to exercise while taking Larotrectinib?
You can exercise while taking Larotrectinib, but be mindful of how your body feels. This medication can cause dizziness, so stay hydrated and avoid strenuous activities if you feel unwell. If you notice dizziness or unusual fatigue during exercise, slow down or stop and rest. Consult your doctor if you have concerns about your exercise routine.
Is it safe to stop Larotrectinib?
It's important not to stop taking Larotrectinib without consulting your doctor. Stopping suddenly can affect your treatment's effectiveness. If you need to stop, your doctor might suggest gradually reducing your dose or switching to a different medication. Always talk with your doctor before making any changes to your medication regimen to ensure your health is protected.
Is Larotrectinib addictive?
No, Larotrectinib is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Larotrectinib works by targeting specific proteins in cancer cells, and this mechanism doesn't affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that Larotrectinib doesn't carry this risk.
Is Larotrectinib safe for the elderly?
Elderly patients may be more vulnerable to side effects from Larotrectinib, such as dizziness or liver problems. It's important for older adults to be closely monitored by their healthcare provider while taking this medication. Regular check-ups and tests can help ensure the treatment is safe and effective for elderly patients.
What are the most common side effects of Larotrectinib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Larotrectinib include fatigue, dizziness, and nausea. These effects vary from person to person. If you notice new symptoms after starting Larotrectinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Larotrectinib?
Don't take Larotrectinib if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Larotrectinib should be used with caution in patients with severe liver problems, as it can affect liver function. Always consult your doctor about any concerns or conditions you have before starting Larotrectinib.
