Lapatinib
.svg)
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Lapatinib
Summary
Lapatinib is used to treat advanced or metastatic breast cancer, specifically HER2-positive and hormone receptor-positive types. It is usually used when other chemotherapy medications have not been successful.
Lapatinib works by inhibiting the tyrosine kinase domains of the HER2 and EGFR receptors. These receptors are involved in the growth and spread of cancer cells. By blocking these receptors, Lapatinib helps slow or stop the progression of cancer.
Lapatinib is typically prescribed for adults with a usual daily dose of 1250 mg when used with capecitabine for HER2-positive metastatic breast cancer and 1500 mg when used with letrozole for hormone receptor-positive HER2-positive metastatic breast cancer. It is taken orally.
Common side effects of Lapatinib include diarrhea, nausea, vomiting, and rash. Serious adverse effects include hepatotoxicity, decreased left ventricular ejection fraction, and severe diarrhea which can lead to dehydration.
Lapatinib carries warnings for severe and potentially life-threatening hepatotoxicity and cardiac effects, including decreased left ventricular ejection fraction. It should not be used by patients with known severe hypersensitivity to the drug or its components. Liver function and cardiac health should be closely monitored.
Indications and Purpose
How does Lapatinib work?
Lapatinib works by blocking certain proteins in cancer cells that promote growth. It belongs to a class of drugs called tyrosine kinase inhibitors. Think of it like turning off a switch that allows cancer cells to grow and spread. By blocking these proteins, Lapatinib helps slow the progression of cancer and can improve survival rates in patients with HER2-positive breast cancer.
Is Lapatinib effective?
Lapatinib is effective in treating certain types of breast cancer, particularly HER2-positive breast cancer. It works by blocking proteins that promote cancer cell growth. Clinical studies show Lapatinib can slow cancer progression and improve survival rates when used with other treatments. Your doctor will monitor your response to Lapatinib through regular check-ups and tests to ensure it's working effectively for your condition.
What is Lapatinib?
Lapatinib is a medication used to treat certain types of breast cancer. It belongs to a class of drugs called tyrosine kinase inhibitors, which work by blocking proteins that promote cancer cell growth. Lapatinib is often used in combination with other cancer treatments to improve effectiveness. It helps slow the progression of cancer and can improve survival rates in patients with HER2-positive breast cancer.
Directions for Use
For how long do I take Lapatinib?
Lapatinib is usually a long-term medication for managing certain types of breast cancer. You'll typically take Lapatinib every day as part of your cancer treatment plan unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Lapatinib treatment.
How do I dispose of Lapatinib?
If you can, bring unused Lapatinib to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Lapatinib?
Take Lapatinib exactly as your doctor prescribes. It's usually taken once daily, either in the morning or evening, on an empty stomach, at least one hour before or after a meal. Swallow the tablets whole with water; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose. Never take two doses at once. Always follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for Lapatinib to start working?
Lapatinib begins working in your body shortly after you take it, but the full therapeutic effects may take several weeks to become noticeable. The time it takes to see results can vary based on individual factors like your overall health and the specific cancer being treated. Regular check-ups and tests with your doctor will help monitor your progress and determine how well Lapatinib is working for you.
How should I store Lapatinib?
Store Lapatinib tablets at room temperature, away from moisture and light. Keep them in a tightly closed container. Don't store your medicine in humid places like bathrooms, where moisture could affect how well the medication works. Always store Lapatinib out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Lapatinib?
The usual starting dose of Lapatinib for adults is 1,250 mg once daily, taken on an empty stomach. Your doctor may adjust your dose based on your response and any side effects. It's important to follow your doctor's specific dosing instructions. Lapatinib is not typically used in children, and elderly patients may require careful monitoring. Always consult your doctor for personalized dosing advice.
Warnings and Precautions
Can I take Lapatinib with other prescription drugs?
Lapatinib can interact with certain medications, increasing the risk of side effects or reducing effectiveness. Major interactions include drugs that affect liver enzymes, like ketoconazole, which can increase Lapatinib levels. Moderate interactions include certain heart medications. Always inform your doctor about all medications you're taking to avoid potential interactions.
Can Lapatinib be taken safely while breastfeeding?
Lapatinib is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. However, it may pose risks to a breastfed baby. If you're taking Lapatinib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Lapatinib be taken safely while pregnant?
Lapatinib is not recommended during pregnancy. It can harm an unborn baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby. Always use effective birth control while taking Lapatinib to prevent pregnancy.
Does Lapatinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Lapatinib include diarrhea, rash, and nausea. These occur in more than 10% of patients. Serious adverse effects can include liver problems and heart issues. If you notice any new or worsening symptoms, contact your doctor immediately. They can help determine if these symptoms are related to Lapatinib and provide appropriate care.
Does Lapatinib have any safety warnings?
Yes, Lapatinib has important safety warnings. It can cause liver problems, so regular liver function tests are necessary. Signs of liver issues include yellowing of the skin or eyes, dark urine, or severe fatigue. Lapatinib may also cause heart problems, such as decreased heart function. If you experience shortness of breath, swelling, or rapid weight gain, seek medical help. Always adhere to your doctor's advice and report any unusual symptoms.
Is it safe to drink alcohol while taking Lapatinib?
It's best to avoid alcohol while taking Lapatinib. Alcohol can increase the risk of liver problems, which are a potential side effect of Lapatinib. Drinking alcohol may also worsen side effects like nausea or dizziness. If you do choose to drink occasionally, limit how much alcohol you consume and watch for any unusual symptoms. Talk with your doctor about alcohol use while taking Lapatinib to get personalized advice.
Is it safe to exercise while taking Lapatinib?
You can exercise while taking Lapatinib, but keep a few things in mind. This medication can cause fatigue or dizziness, which might affect your ability to exercise. Listen to your body and avoid strenuous activities if you feel unwell. To exercise safely, stay hydrated and take breaks as needed. Most people can maintain their regular exercise routine while taking Lapatinib, but check with your doctor if you have concerns.
Is it safe to stop Lapatinib?
Stopping Lapatinib suddenly can affect your treatment's effectiveness. If you're taking it for cancer, stopping could allow the cancer to progress. Always talk with your doctor before stopping Lapatinib. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
Is Lapatinib addictive?
Lapatinib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Lapatinib works by targeting specific proteins in cancer cells and doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Lapatinib doesn't carry this risk.
Is Lapatinib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Lapatinib, such as heart and liver problems. They may also experience more severe side effects. Regular monitoring by a healthcare provider is important to ensure safety. Dose adjustments may be necessary based on individual health conditions. Always consult your doctor for personalized advice when using Lapatinib.
What are the most common side effects of Lapatinib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Lapatinib include diarrhea, rash, and nausea. These occur in more than 10% of patients. If you notice new symptoms after starting Lapatinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Lapatinib?
Don't take Lapatinib if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Lapatinib is not recommended for people with severe liver problems, as it can worsen liver function. Use caution if you have heart issues, as Lapatinib can affect heart function. Always consult your doctor about these concerns before starting Lapatinib.
Forms / Brands
