Ixazomib
Multiple Myeloma
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Proteasome Inhibitor
Controlled Drug Substance
No
Ixazomib
Summary
Ixazomib is used in combination with other medications to treat multiple myeloma, a type of cancer that affects plasma cells in your bone marrow. It is typically used in patients who have already undergone at least one prior therapy.
Ixazomib is a type of drug called a proteasome inhibitor. It works by blocking the action of proteasomes, which are protein complexes that break down unneeded or damaged proteins in cells. By doing this, Ixazomib disrupts the normal function of cancer cells, leading to their death and helping to control the progression of multiple myeloma.
The usual dose of Ixazomib for adults is 4 mg taken once a week on Days 1, 8, and 15 of a 28-day treatment cycle. It is taken orally, by swallowing the capsules whole with water.
Common side effects of Ixazomib include diarrhea, constipation, nausea, vomiting, and peripheral neuropathy (nerve damage resulting in pain or numbness). More serious adverse effects can include low platelet count, liver damage, and blood clotting disorders.
Ixazomib can cause fetal harm, so it should not be taken by pregnant women. Women of reproductive potential should use effective contraception during treatment and for 90 days after the last dose. It is also not recommended for breastfeeding women. Ixazomib is contraindicated in patients with hypersensitivity to the active substance or any of its components.
Indications and Purpose
How does Ixazomib work?
Ixazomib is a proteasome inhibitor, which means it blocks protein complexes in cells that help cancer cells grow. Think of it like stopping a machine that recycles proteins in cells. By blocking this process, Ixazomib helps control the growth of cancer cells. This action makes it effective in treating multiple myeloma, a type of blood cancer.
Is Ixazomib effective?
Ixazomib is effective in treating multiple myeloma, which is a type of blood cancer. Clinical studies show it helps slow disease progression and improve survival rates when used with other medications. It works by inhibiting proteasomes, which are protein complexes that help cancer cells grow. This action helps control the disease and improve patient outcomes.
What is Ixazomib?
Ixazomib is a medication used to treat multiple myeloma, which is a type of blood cancer. It belongs to a class of drugs called proteasome inhibitors, which work by blocking protein complexes that help cancer cells grow. This action helps control the disease and improve patient outcomes. Ixazomib is often used in combination with other therapies.
Directions for Use
For how long do I take Ixazomib?
Ixazomib is usually a long-term medication for managing multiple myeloma, a type of blood cancer. You'll typically take Ixazomib as part of a treatment cycle, which your doctor will determine based on your condition and response. Always talk with your doctor before changing or stopping your Ixazomib treatment.
How do I dispose of Ixazomib?
Dispose of unused Ixazomib by taking it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Ixazomib?
Take Ixazomib on an empty stomach, at least one hour before or two hours after eating. Swallow the capsule whole with water, without crushing or chewing it. It's usually taken once a week on the same day and time. If you miss a dose, take it as soon as you remember unless it's within three days of your next dose. In that case, skip the missed dose and continue your regular schedule. Always follow your doctor's specific instructions.
How long does it take for Ixazomib to start working?
Ixazomib starts working in your body shortly after you take it, but the full therapeutic effects may take weeks to months to appear. The time it takes to see benefits can depend on your overall health and response to treatment. Regular check-ups with your doctor are important to monitor your progress and adjust your treatment as needed.
How should I store Ixazomib?
Store Ixazomib at room temperature, away from moisture and light. Keep it in its original container, tightly closed. Don't store it in humid places like bathrooms. Always keep Ixazomib out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Ixazomib?
The usual starting dose of Ixazomib for adults is 4 mg taken once a week on the same day and time. Your doctor may adjust your dose based on your response and any side effects. The maximum recommended dose is 4 mg per week. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can I take Ixazomib with other prescription drugs?
Ixazomib can interact with certain medications, increasing the risk of side effects or reducing effectiveness. Strong CYP3A inducers, like rifampin, can decrease Ixazomib levels, making it less effective. Always inform your doctor about all medications you take to avoid interactions. Your doctor can adjust your treatment plan to ensure safety and effectiveness.
Can Ixazomib be taken safely while breastfeeding?
Ixazomib is not recommended while breastfeeding. We don't have much information about whether it passes into human breast milk. However, it may pose risks to a nursing infant. If you're taking Ixazomib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Ixazomib be taken safely while pregnant?
Ixazomib is not recommended during pregnancy. It may harm an unborn baby. We don't have much information about its use in pregnant women, but animal studies suggest potential risks. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for your condition.
Does Ixazomib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Ixazomib include nausea, vomiting, diarrhea, and low blood cell counts. Serious effects can include liver problems and severe skin reactions. If you notice any new or worsening symptoms, contact your doctor immediately. Regular monitoring by your healthcare provider is important to manage any adverse effects.
Does Ixazomib have any safety warnings?
Yes, Ixazomib has important safety warnings. It can cause low blood cell counts, which may increase infection risk. It may also cause liver problems, so regular monitoring is needed. If you experience symptoms like fever, unusual bruising, or yellowing of the skin, contact your doctor immediately. Always adhere to your doctor's advice and report any new or worsening symptoms.
Is it safe to drink alcohol while taking Ixazomib?
It's best to avoid alcohol while taking Ixazomib. Alcohol can increase the risk of liver problems and worsen side effects like nausea or dizziness. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like nausea or dizziness. Talk with your doctor about alcohol use while taking Ixazomib for personalized advice.
Is it safe to exercise while taking Ixazomib?
You can exercise while taking Ixazomib, but keep a few things in mind. This medication can cause fatigue and dizziness, which might affect your exercise capacity. To exercise safely, listen to your body and avoid strenuous activities if you feel tired. Drink plenty of water before, during, and after physical activity. If you notice unusual fatigue or dizziness, slow down or stop exercising and rest.
Is it safe to stop Ixazomib?
Stopping Ixazomib suddenly can affect your treatment. It's used for long-term management of certain cancers. Stopping without medical advice could worsen your condition. Always talk with your doctor before stopping Ixazomib. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control.
Is Ixazomib addictive?
Ixazomib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Ixazomib works by affecting cancer cells, not brain chemistry, so it doesn't lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Ixazomib safe for the elderly?
Elderly patients may be more vulnerable to side effects of Ixazomib, such as low blood cell counts and liver problems. Regular monitoring is important to manage these risks. Ixazomib can be used safely in the elderly with careful dose adjustments and close supervision by a healthcare provider. Always consult your doctor about any concerns.
What are the most common side effects of Ixazomib?
Side effects are unwanted reactions to a medication. Common side effects of Ixazomib include nausea, vomiting, diarrhea, and fatigue. These effects vary from person to person. If you notice new symptoms after starting Ixazomib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Ixazomib?
Don't take Ixazomib if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Ixazomib isn't for people with severe liver problems, as it may worsen liver function. Always consult your doctor about any concerns and inform them of your medical history before starting Ixazomib.
