Ivosidenib
Acute Myeloid Leukemia
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Isocitrate Dehydrogenase 1 Inhibitor
Controlled Drug Substance
No
ivosidenib
Summary
Ivosidenib is used to treat certain types of cancer, such as acute myeloid leukemia, which is a cancer of the blood and bone marrow, with a specific genetic mutation. It helps slow the growth of cancer cells and improve survival rates.
Ivosidenib works by inhibiting the IDH1 enzyme, which is involved in cancer cell growth. By blocking this enzyme, it helps slow down the growth of cancer cells, effectively managing the progression of certain cancers.
The usual starting dose of Ivosidenib for adults is 500 mg once daily. It is taken orally, which means by mouth, and can be taken with or without food. It's important to follow your doctor's instructions on how to take it.
Common side effects of Ivosidenib include nausea, which is feeling sick to your stomach, diarrhea, which is loose or watery stools, and fatigue, which is feeling very tired. These effects can vary in frequency and severity among individuals.
Ivosidenib can cause differentiation syndrome, which is a serious reaction with symptoms like fever and difficulty breathing. It can also cause QT prolongation, which affects heart rhythm. It's not recommended for those with a known allergy to it or its ingredients.
Indications and Purpose
How does Ivosidenib work?
Ivosidenib works by inhibiting the IDH1 enzyme, which is involved in cancer cell growth. By blocking this enzyme, Ivosidenib helps slow down the growth of cancer cells. Think of it like turning off a switch that powers cancer cell growth. This action helps manage certain types of cancer, such as acute myeloid leukemia.
Is Ivosidenib effective?
Ivosidenib is effective in treating certain types of cancer, such as acute myeloid leukemia with a specific genetic mutation. Clinical studies show it can help reduce cancer cell growth and improve survival rates. Your doctor will monitor your progress to ensure the medication is working effectively for your condition.
What is Ivosidenib?
Ivosidenib is a medication used to treat certain types of cancer, such as acute myeloid leukemia with a specific genetic mutation. It works by inhibiting an enzyme that promotes cancer cell growth. Ivosidenib is part of a class of drugs called IDH1 inhibitors and is used to slow the progression of cancer.
Directions for Use
For how long do I take Ivosidenib?
Ivosidenib is usually taken long-term for chronic conditions like certain types of cancer. The duration of use depends on your response to treatment and your doctor's recommendations. Always follow your doctor's guidance on how long to take Ivosidenib and discuss any concerns about your treatment plan.
How do I dispose of Ivosidenib?
Dispose of unused Ivosidenib by taking it to a drug take-back program or collection site at a pharmacy or hospital. If that's not possible, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away in the trash. This helps prevent harm to people and the environment.
How do I take Ivosidenib?
Take Ivosidenib as prescribed by your doctor, usually once daily. You can take it with or without food. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Follow your doctor's advice on any dietary or beverage restrictions.
How long does it take for Ivosidenib to start working?
Ivosidenib starts working in your body shortly after you take it, but the full therapeutic effects may take weeks to months to become noticeable. The time it takes to work can depend on your specific condition and overall health. Regular monitoring by your doctor will help assess the medication's effectiveness.
How should I store Ivosidenib?
Store Ivosidenib at room temperature, away from moisture and light. Keep it in a tightly closed container and out of reach of children. Do not store it in humid places like bathrooms. Check the expiration date regularly and dispose of any unused or expired medication properly.
What is the usual dose of Ivosidenib?
The usual starting dose of Ivosidenib for adults is 500 mg once daily. Your doctor will provide specific dosing instructions based on your health needs. It's important to follow your doctor's guidance and not adjust the dose on your own. If you have any concerns about your dosage, discuss them with your healthcare provider.
Warnings and Precautions
Can I take Ivosidenib with other prescription drugs?
Ivosidenib can interact with other medications, increasing the risk of side effects or reducing effectiveness. It's important to inform your doctor about all medications you're taking, including over-the-counter drugs and supplements. Your doctor will help manage potential interactions to ensure safe and effective treatment.
Can Ivosidenib be taken safely while breastfeeding?
Ivosidenib is not recommended while breastfeeding. There is limited information on whether it passes into breast milk. To avoid potential risks to the baby, discuss safer medication options with your doctor if you wish to breastfeed while undergoing treatment.
Can Ivosidenib be taken safely while pregnant?
Ivosidenib is not recommended during pregnancy due to potential risks to the unborn baby. There is limited information on its safety in pregnant women. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for your condition.
Does Ivosidenib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Ivosidenib include nausea, diarrhea, and fatigue. These effects vary in frequency and severity. Serious side effects can include differentiation syndrome and QT prolongation, which require immediate medical attention. Always inform your doctor about any new or worsening symptoms while taking Ivosidenib.
Does Ivosidenib have any safety warnings?
Yes, Ivosidenib has important safety warnings. It can cause a condition called differentiation syndrome, which is a potentially life-threatening reaction. Symptoms include fever, difficulty breathing, and weight gain. If you experience these, seek medical help immediately. Ivosidenib can also cause QT prolongation, which affects heart rhythm. Regular monitoring by your doctor is essential to manage these risks.
Is it safe to drink alcohol while taking Ivosidenib?
It's best to avoid alcohol while taking Ivosidenib. Alcohol can interfere with the medication's effectiveness and increase the risk of side effects. If you choose to drink occasionally, limit your intake and discuss it with your doctor to get personalized advice based on your health situation.
Is it safe to exercise while taking Ivosidenib?
You can exercise while taking Ivosidenib, but be mindful of how your body feels. This medication can cause fatigue, so listen to your body and avoid strenuous activities if you feel tired. Stay hydrated and rest if you experience dizziness or unusual fatigue during exercise. Consult your doctor if you have concerns.
Is it safe to stop Ivosidenib?
Stopping Ivosidenib suddenly can affect your treatment. It's important to talk with your doctor before stopping the medication. They might suggest a gradual reduction or an alternative treatment to manage your condition safely. Your doctor will guide you on how to make any medication changes to protect your health.
Is Ivosidenib addictive?
Ivosidenib is not considered addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Ivosidenib works by targeting specific cancer cells and does not affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, discuss them with your doctor.
Is Ivosidenib safe for the elderly?
Elderly patients may be more vulnerable to side effects of Ivosidenib, such as fatigue and heart rhythm changes. Regular monitoring by a doctor is important to manage these risks. Discuss any concerns with your healthcare provider to ensure safe and effective treatment.
What are the most common side effects of Ivosidenib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Ivosidenib include nausea, diarrhea, and fatigue. These effects vary from person to person. If you notice new symptoms after starting Ivosidenib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Ivosidenib?
Ivosidenib should not be used if you have a known allergy to it or its ingredients. It is also contraindicated in patients with a history of QT prolongation, which affects heart rhythm. Always inform your doctor about your medical history and any other medications you are taking to avoid potential risks.
