Istradefylline
Parkinson Disease
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
istradefylline
Summary
Istradefylline is used to treat Parkinson's disease, which is a condition that affects movement. It helps reduce "off" time, which is when symptoms return between medication doses, improving movement control and daily functioning.
Istradefylline works by blocking adenosine, which is a brain chemical that slows down movement. By blocking this chemical, it helps improve movement control and reduce "off" time in people with Parkinson's disease.
The usual starting dose of Istradefylline for adults is 20 mg once daily. Your doctor may adjust your dose based on your response. The maximum recommended dose is 40 mg daily. It can be taken with or without food.
Common side effects of Istradefylline include dyskinesia, which is involuntary muscle movements, and dizziness. These effects vary from person to person and should be discussed with a doctor if they occur.
Istradefylline may cause or worsen dyskinesia and can cause hallucinations or psychotic behavior. It should not be taken if allergic to it or its ingredients. Caution is advised for those with severe liver problems.
Indications and Purpose
How does Istradefylline work?
Istradefylline works by blocking a brain chemical called adenosine, which helps improve movement control in people with Parkinson's disease. Think of it like turning off a switch that slows down movement. By blocking adenosine, Istradefylline helps reduce "off" time, which is when symptoms return between medication doses. This improves daily functioning and quality of life for people with Parkinson's disease.
Is Istradefylline effective?
Istradefylline is effective in treating Parkinson's disease, which is a condition that affects movement. It works by blocking a brain chemical called adenosine, which helps improve movement control. Clinical studies show Istradefylline can reduce "off" time, which is when Parkinson's symptoms return between medication doses. This helps improve daily functioning and quality of life for people with Parkinson's disease.
What is Istradefylline?
Istradefylline is a medication used to treat Parkinson's disease, which is a condition that affects movement. It belongs to a class of drugs called adenosine A2A receptor antagonists. Istradefylline works by blocking a brain chemical called adenosine, which helps improve movement control. It's used as an add-on treatment to other Parkinson's medications to help reduce "off" time, which is when symptoms return between medication doses.
Directions for Use
For how long do I take Istradefylline?
Istradefylline is usually a long-term medication for managing Parkinson's disease. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your symptoms to worsen. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Istradefylline treatment.
How do I dispose of Istradefylline?
If you can, bring unused Istradefylline to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Istradefylline?
Istradefylline is usually taken once daily, with or without food. It's important to follow your doctor's instructions on the exact timing and dosage. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for Istradefylline to start working?
Istradefylline begins working in your body shortly after you take it, but you may not notice all the benefits right away. For Parkinson's disease, you might see some improvement in symptoms within a few weeks. The full benefits may take longer to appear. How quickly the medication works can depend on your overall health and how your body responds. Take it exactly as prescribed for the best results.
How should I store Istradefylline?
Store Istradefylline at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Don't store your medicine in humid places like bathrooms, where moisture in the air could affect how well the medication works. Always store Istradefylline out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Istradefylline?
The usual starting dose of Istradefylline for adults is 20 mg once daily. Your doctor may adjust your dose based on your response to the medication and any side effects you experience. The maximum recommended dose is 40 mg daily. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can Istradefylline be taken safely while breastfeeding?
The safety of Istradefylline while breastfeeding is not well-established. It's unclear if this medication passes into human breast milk. If you're taking Istradefylline and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely. Your doctor can help you make informed decisions about your treatment.
Can Istradefylline be taken safely while pregnant?
The safety of Istradefylline during pregnancy is not well-established. There is limited evidence on its effects in pregnant women. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take Istradefylline with other prescription drugs?
Istradefylline may interact with certain medications, including strong CYP3A4 inhibitors like ketoconazole, which can increase its levels in the body. This may increase the risk of side effects. Always inform your doctor about all the medications you are taking to avoid potential interactions. Your doctor can adjust your treatment plan to ensure safety and effectiveness.
Does Istradefylline have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Istradefylline include dyskinesia, which is involuntary muscle movements, and dizziness. These effects vary in frequency and severity. If you experience severe or persistent adverse effects, contact your doctor. They can help determine if the symptoms are related to Istradefylline and suggest appropriate management.
Does Istradefylline have any safety warnings?
Istradefylline has important safety warnings. It may cause or worsen dyskinesia, which is involuntary muscle movements, in people with Parkinson's disease. If you experience new or worsening movements, contact your doctor. Istradefylline can also cause hallucinations or psychotic behavior. If you notice changes in your mood or behavior, seek medical advice. Always follow your doctor's instructions and report any unusual symptoms.
Is Istradefylline addictive?
Istradefylline is not considered addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Istradefylline works by affecting certain brain chemicals but doesn't lead to addiction. If you have concerns about medication dependence, you can feel confident that Istradefylline doesn't carry this risk while managing your health condition.
Is Istradefylline safe for the elderly?
Elderly individuals may be more sensitive to the effects of Istradefylline, especially dizziness or drowsiness. These side effects can increase the risk of falls. It's important for elderly patients to be monitored closely by their doctor while taking this medication. Your doctor can help adjust the dose if needed to ensure safety and effectiveness.
Is it safe to drink alcohol while taking Istradefylline?
It's best to avoid alcohol while taking Istradefylline. Alcohol can worsen side effects like dizziness or drowsiness. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like dizziness or trouble concentrating. Talk with your doctor about alcohol use while taking Istradefylline to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Istradefylline?
You can exercise while taking Istradefylline, but keep a few things in mind. This medication may cause dizziness, which could affect your balance during exercise. To exercise safely, start with light activities and gradually increase intensity. If you feel dizzy or lightheaded, slow down or stop exercising and rest. Most people can maintain their regular exercise routine while taking Istradefylline, but check with your doctor if you have concerns.
Is it safe to stop Istradefylline?
Istradefylline is usually used for long-term management of Parkinson's disease. Stopping it suddenly may worsen your symptoms. Always talk with your doctor before stopping Istradefylline. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
What are the most common side effects of Istradefylline?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Istradefylline include dyskinesia, which is involuntary muscle movements, and dizziness. These effects vary from person to person. If you notice new symptoms after starting Istradefylline, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Istradefylline?
Don't take Istradefylline if you're allergic to it or its ingredients. Serious allergic reactions, which cause rash, hives, or swelling that makes breathing difficult, require immediate medical help. Istradefylline should be used with caution in people with severe liver problems, as it may not be safe. Always consult your doctor about these concerns before starting Istradefylline.
