Inebilizumab
NA
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
CD19-directed Cytolytic Antibody
Controlled Drug Substance
No
Summary
Inebilizumab is used to treat neuromyelitis optica spectrum disorder, which is a condition affecting the eyes and spinal cord. It helps reduce the risk of relapses by targeting specific proteins in the immune system.
Inebilizumab is a monoclonal antibody, which is a type of protein made in the lab. It targets a protein called CD19 on B cells, which are immune cells, reducing their number to decrease inflammation and prevent relapses.
Inebilizumab is given as an intravenous infusion, which means it's delivered directly into a vein. The usual dose is 300 mg initially, followed by another 300 mg two weeks later, and then 300 mg every six months.
Common side effects of inebilizumab include infusion-related reactions, which are symptoms like fever or chills, and infections. These effects can vary from person to person.
Inebilizumab can increase the risk of infections, including serious ones. It's not for use in people with active infections or those allergic to it. Always consult your doctor about any health concerns before starting treatment.
Indications and Purpose
How does inebilizumab work?
Inebilizumab is a monoclonal antibody that targets a protein called CD19 on B cells, which are a type of immune cell. By binding to CD19, inebilizumab reduces the number of B cells, which helps decrease inflammation and prevent relapses in neuromyelitis optica spectrum disorder.
Is inebilizumab effective?
Inebilizumab is effective in treating neuromyelitis optica spectrum disorder, which is a condition that affects the eyes and spinal cord. Clinical studies show it reduces the risk of relapse in patients. It works by targeting specific proteins in the immune system, helping to manage the disease.
What is inebilizumab?
Inebilizumab is a medication used to treat neuromyelitis optica spectrum disorder, which is a condition affecting the eyes and spinal cord. It belongs to a class of drugs called monoclonal antibodies, which work by targeting specific proteins in the immune system to reduce inflammation and prevent relapses.
Directions for Use
For how long do I take inebilizumab?
Inebilizumab is usually a long-term medication for managing neuromyelitis optica spectrum disorder. You'll typically receive infusions every six months as part of ongoing treatment. How long you'll need this medication depends on your body's response and overall health. Always talk with your doctor before changing or stopping your treatment.
How do I dispose of inebilizumab?
Bring unused inebilizumab to a drug take-back program or collection site at a pharmacy or hospital. If unavailable, mix it with something undesirable like used coffee grounds, seal in a plastic bag, and throw it away. This prevents harm to people and the environment.
How do I take inebilizumab?
Inebilizumab is administered as an intravenous infusion, typically given every six months after the initial doses. It should be administered by a healthcare professional. There are no specific dietary or beverage restrictions, but always follow your doctor's advice. If you miss a scheduled infusion, contact your healthcare provider to reschedule as soon as possible.
How long does it take for inebilizumab to start working?
Inebilizumab starts working in your body shortly after the infusion. However, the full therapeutic effect, such as reducing relapses, may take several weeks to months. Individual factors like your overall health and disease severity can affect how quickly you notice improvements. Follow your doctor's instructions for the best results.
How should I store inebilizumab?
Store inebilizumab in a refrigerator at 36°F to 46°F (2°C to 8°C). Keep it in its original packaging to protect it from light. Do not freeze or shake the medication. Always store it out of children's reach to prevent accidental use.
What is the usual dose of inebilizumab?
The usual dose of inebilizumab for adults is an initial infusion of 300 mg, followed by a second 300 mg infusion two weeks later. After that, 300 mg is given every six months. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can inebilizumab be taken safely while breastfeeding?
The safety of inebilizumab while breastfeeding is not well-established. It's unknown if it passes into breast milk or affects milk supply. If you're breastfeeding or planning to, discuss with your doctor to find the safest treatment options for you and your baby.
Can inebilizumab be taken safely while pregnant?
The safety of inebilizumab during pregnancy is not well-established. Limited data is available, and its effects on unborn babies are unknown. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for your condition.
Can I take inebilizumab with other prescription drugs?
Inebilizumab may interact with medications that affect the immune system, increasing the risk of infections. It's important to inform your doctor about all the medications you're taking to avoid potential interactions. Your doctor can help manage any risks and adjust your treatment as needed.
Does inebilizumab have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of inebilizumab include infusion-related reactions and infections. Serious side effects can include severe infections and low blood cell counts. If you notice any new or worsening symptoms, contact your doctor immediately.
Does inebilizumab have any safety warnings?
Inebilizumab has important safety warnings. It can increase the risk of infections, including serious ones. It may also cause infusion-related reactions. Not adhering to these warnings can lead to severe health issues. Always follow your doctor's advice and report any unusual symptoms immediately.
Is inebilizumab addictive?
Inebilizumab is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. This medication works by targeting specific proteins in the immune system and doesn't affect brain chemistry in ways that could lead to addiction.
Is inebilizumab safe for the elderly?
Elderly patients may be more vulnerable to the side effects of inebilizumab, such as infections. It's important for older adults to be closely monitored by their healthcare provider while on this medication. Discuss any concerns with your doctor to ensure safe and effective treatment.
Is it safe to drink alcohol while taking inebilizumab?
There's no well-established interaction between inebilizumab and alcohol. However, alcohol can weaken your immune system, which may increase the risk of infections. It's best to limit alcohol consumption and discuss with your doctor for personalized advice.
Is it safe to exercise while taking inebilizumab?
You can exercise while taking inebilizumab, but be mindful of your body's response. This medication may increase the risk of infections, so avoid strenuous activities if you're feeling unwell. Stay hydrated and listen to your body. Consult your doctor if you have concerns.
Is it safe to stop inebilizumab?
Stopping inebilizumab suddenly can affect your health condition. It's used for long-term management of certain autoimmune diseases. Stopping it without medical advice could worsen your condition. Always talk with your doctor before stopping inebilizumab. They can guide you on how to safely adjust your treatment.
What are the most common side effects of inebilizumab?
Side effects are unwanted reactions to a medication. Common side effects of inebilizumab include infusion-related reactions, such as fever or chills, and infections. These effects vary from person to person. If you notice new symptoms, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking inebilizumab?
Don't use inebilizumab if you're allergic to it or its ingredients. It's contraindicated in patients with active infections. Caution is needed in those with a history of infections or weakened immune systems. Always consult your doctor about these concerns before starting treatment.
