Indomethacin
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Nonsteroidal Anti-inflammatory Drug
Controlled Drug Substance
NO
Indomethacin
Summary
Indomethacin is used for treating conditions that cause pain, swelling, redness, and fever. It's often used for arthritis pain, stiff achy joints, period cramps, and other short-term pains. It can also help reduce joint swelling and improve mobility in patients with arthritis.
Indomethacin works by inhibiting the synthesis of prostaglandins, substances in the body that cause inflammation, pain, and fever. It helps to reduce these symptoms but doesn't cure the underlying condition causing them.
Adults typically take 150 to 200 milligrams of Indomethacin daily. For children over two, the dose is determined based on their weight, but it should not exceed 150-200 mg per day. The medicine is taken orally, usually with food or antacids to reduce stomach side effects.
Common side effects of Indomethacin include upset stomach, nausea, vomiting, indigestion, heartburn, and stomach pain. Less common but serious side effects include ulcers, bleeding in the stomach or intestines, and liver problems. It can also cause drowsiness, fatigue, and dizziness.
Indomethacin should not be used during pregnancy, especially after 20 weeks. It can also cause serious problems like heart attacks, strokes, and stomach ulcers. It's important to avoid alcohol while taking this medicine to lower the risk of stomach ulcers and bleeding. You should also tell your doctor about any other medicines you're taking as Indomethacin can interact with them.
Indications and Purpose
How does Indomethacin work?
Indomethacin works by blocking enzymes called COX-1 and COX-2, which produce substances that cause inflammation and pain. Think of it like turning off a faucet to stop water flow. This action reduces swelling and discomfort in conditions like arthritis.
Is Indomethacin effective?
Indomethacin is effective for reducing pain and inflammation in conditions like arthritis. It works by blocking substances in the body that cause inflammation. Clinical studies support its effectiveness in managing these symptoms.
What is Indomethacin?
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. It works by blocking substances in the body that cause inflammation. It's commonly used for conditions like arthritis and gout.
Directions for Use
For how long do I take Indomethacin?
Indomethacin is typically used for short-term relief of pain and inflammation. The duration depends on your condition and doctor's advice. Follow your doctor's instructions and do not use it longer than recommended to avoid side effects.
How do I dispose of Indomethacin?
Dispose of Indomethacin by taking it to a drug take-back program or collection site. If unavailable, mix it with undesirable substances like coffee grounds, seal in a plastic bag, and throw it in the trash. Do not flush it down the toilet.
How do I take Indomethacin?
Take Indomethacin as prescribed by your doctor. It's usually taken two to three times a day with food to prevent stomach upset. Do not crush or chew the capsules. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Avoid taking two doses at once.
How long does it take for Indomethacin to start working?
Indomethacin starts working within a few hours to relieve pain and inflammation. Full effects may take a few days. Individual response times can vary based on factors like the condition being treated and overall health.
How should I store Indomethacin?
Store Indomethacin at room temperature, away from moisture and light. Keep it in a tightly closed container. Do not store it in the bathroom, where humidity can affect it. Keep it out of reach of children and pets.
What is the usual dose of Indomethacin?
The usual starting dose of Indomethacin for adults is 25 mg two to three times daily. Your doctor may adjust the dose based on your response and needs. The maximum recommended dose is 200 mg per day. Always follow your doctor's dosing instructions.
Warnings and Precautions
Can Indomethacin be taken safely while breastfeeding?
Indomethacin is generally considered safe while breastfeeding, but it can pass into breast milk in small amounts. Monitor your baby for any unusual symptoms. Consult your doctor to discuss the benefits and risks of using Indomethacin while nursing.
Can Indomethacin be taken safely while pregnant?
Indomethacin is not recommended during pregnancy, especially in the third trimester. It may affect the baby's heart and blood flow. Limited data exist on its safety, so consult your doctor for advice on managing pain during pregnancy.
Can I take Indomethacin with other prescription drugs?
Indomethacin can interact with blood thinners like warfarin, increasing bleeding risk. It may also interact with other NSAIDs, raising the chance of stomach issues. Always inform your doctor about all medications you take to avoid harmful interactions.
Does Indomethacin have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Indomethacin include stomach upset, dizziness, and headache. Serious effects like heart attack or stroke are rare but require immediate medical attention. Report any new or worsening symptoms to your doctor.
Does Indomethacin have any safety warnings?
Yes, Indomethacin has safety warnings. It can increase the risk of heart attack or stroke, especially with long-term use. It may also cause stomach bleeding. Follow your doctor's instructions and report any unusual symptoms like chest pain or severe stomach pain immediately.
Is Indomethacin addictive?
Indomethacin is not addictive. It does not cause physical or psychological dependence. You won't experience cravings or withdrawal symptoms when stopping it. Always use it as prescribed by your doctor to manage your condition safely.
Is Indomethacin safe for the elderly?
Elderly individuals are more vulnerable to the side effects of Indomethacin, such as stomach bleeding and kidney problems. It's important to use the lowest effective dose and monitor for adverse effects. Regular check-ups with a doctor are recommended to ensure safety.
Is it safe to drink alcohol while taking Indomethacin?
It's best to avoid alcohol while taking Indomethacin. Alcohol can increase the risk of stomach bleeding and worsen side effects like dizziness. If you choose to drink, do so in moderation and watch for any adverse symptoms.
Is it safe to exercise while taking Indomethacin?
Yes, you can exercise while taking Indomethacin. However, be aware that it may cause dizziness or stomach upset. Avoid strenuous activities if you experience these symptoms. Stay hydrated and listen to your body during workouts.
Is it safe to stop Indomethacin?
Indomethacin is often used for short-term relief of pain or inflammation. Stopping it suddenly is usually safe, but your symptoms may return. Always consult your doctor before stopping to ensure it's appropriate for your condition.
What are the most common side effects of Indomethacin?
Side effects are unwanted reactions to a medication. Common side effects of Indomethacin include stomach upset, nausea, and dizziness. These effects vary among individuals. If you experience new symptoms, they may be temporary or unrelated. Consult your doctor before stopping the medication.
Who should avoid taking Indomethacin?
Do not use Indomethacin if you have a history of allergic reactions to it or other NSAIDs. It's contraindicated in people with active stomach ulcers or severe kidney disease. Use caution if you have heart disease or high blood pressure. Always consult your doctor before use.
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