Hydrochlorothiazide + Olmesartan
Find more information about this combination medication at the webpages for olmesartan and hydrochlorothiazide
Hypertension, Left Ventricular Dysfunction ... show more
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Advisory
- This medicine contains a combination of 2 drugs hydrochlorothiazide and olmesartan.
- hydrochlorothiazide and olmesartan are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Angiotensin 2 Receptor Blocker and Thiazide Diuretic
Controlled Drug Substance
NO
Summary
Hydrochlorothiazide and olmesartan are used to treat high blood pressure, which is also known as hypertension. By lowering blood pressure, they help reduce the risk of complications such as heart attack, stroke, and kidney problems. Hydrochlorothiazide may also be used to treat fluid retention, which is known as edema, associated with conditions like heart failure or liver disease.
Hydrochlorothiazide works by increasing urine production, which helps remove excess fluid and salt from the body, reducing blood pressure. Olmesartan works by blocking substances that tighten blood vessels, allowing them to relax and widen, which also lowers blood pressure. Together, they help control high blood pressure by reducing fluid volume and relaxing blood vessels.
The usual adult dose of hydrochlorothiazide ranges from 12.5 mg to 50 mg per day, depending on the individual's needs and response. Olmesartan is typically prescribed at a dose of 20 mg to 40 mg per day. Both medicines are usually taken once daily, and it's important to follow the healthcare provider's instructions to achieve the best results in managing blood pressure.
Common side effects of hydrochlorothiazide include increased urination, dizziness, and electrolyte imbalances, which refer to changes in the levels of minerals in the blood. Olmesartan may cause dizziness, headache, and fatigue. Both medicines can lead to low blood pressure, which is a significant adverse effect. Rarely, olmesartan can cause kidney problems, while hydrochlorothiazide may lead to gout, which is a type of arthritis caused by excess uric acid.
Hydrochlorothiazide should be used cautiously in people with kidney disease or gout, as it can worsen these conditions. Olmesartan is contraindicated in pregnancy due to potential harm to the fetus. Both medicines can cause low blood pressure, so they should be used carefully in people with a history of hypotension, which is abnormally low blood pressure. It's important to monitor blood pressure regularly and report any unusual symptoms to a healthcare provider.
Indications and Purpose
How does combination of hydrochlorothiazide and olmesartan work?
Hydrochlorothiazide works by increasing the amount of urine produced, which helps remove excess fluid and salt from the body, reducing blood pressure. Olmesartan works by blocking the action of a substance that causes blood vessels to tighten, allowing them to relax and widen, which also lowers blood pressure. Together, these medicines help control high blood pressure by reducing fluid volume and relaxing blood vessels. This combination makes it easier for the heart to pump blood and reduces the risk of heart-related issues.
How does combination of Hydrochlorothiazide and Olmesartan work?
Hydrochlorothiazide works by increasing the excretion of sodium and water through the kidneys, which reduces fluid volume and lowers blood pressure. Olmesartan blocks the action of angiotensin II, a substance that narrows blood vessels, thereby relaxing the vessels and improving blood flow. Together, they provide a dual mechanism for controlling high blood pressure: hydrochlorothiazide reduces fluid retention, while olmesartan decreases vascular resistance. This combination effectively lowers blood pressure and reduces the risk of cardiovascular complications.
How effective is combination of hydrochlorothiazide and olmesartan?
Hydrochlorothiazide has been shown to effectively reduce blood pressure by removing excess fluid from the body, which decreases blood volume. Olmesartan has been proven to lower blood pressure by blocking substances that tighten blood vessels. Clinical studies have demonstrated that when used together, these medicines provide a greater reduction in blood pressure than when used alone. The combination is particularly effective for patients who need more than one medication to control their blood pressure. Both medicines share the common goal of reducing blood pressure, thereby lowering the risk of heart disease and stroke.
How effective is combination of Hydrochlorothiazide and Olmesartan?
Clinical trials have demonstrated that hydrochlorothiazide and olmesartan effectively lower blood pressure, reducing the risk of cardiovascular events such as strokes and heart attacks. Hydrochlorothiazide has been shown to decrease fluid retention and improve blood pressure control, while olmesartan effectively relaxes blood vessels by blocking angiotensin II. Together, they provide a comprehensive approach to managing hypertension, with studies indicating significant reductions in blood pressure when used in combination. The combination therapy is well-tolerated and offers an additive effect, enhancing the overall antihypertensive benefit.
Directions for Use
What is the usual dose of combination of hydrochlorothiazide and olmesartan?
The usual adult dose of hydrochlorothiazide ranges from 12.5 mg to 50 mg per day, depending on the individual's needs and response. Olmesartan is typically prescribed at a dose of 20 mg to 40 mg per day. The exact dose of each medicine may vary based on the patient's condition and how they respond to treatment. Both medicines are usually taken once daily, and it's important to follow the healthcare provider's instructions to achieve the best results in managing blood pressure.
What is the usual dose of combination of Hydrochlorothiazide and Olmesartan?
The usual adult daily dose for hydrochlorothiazide when used alone is typically 12.5 to 50 mg, taken once daily. For olmesartan, the usual starting dose is 20 mg once daily, which can be increased to 40 mg if needed. When combined, the typical starting dose is 20 mg of olmesartan with 12.5 mg of hydrochlorothiazide, taken once daily. This combination can be adjusted based on the patient's response and tolerance, with a maximum dose of 40 mg olmesartan and 25 mg hydrochlorothiazide per day. Both medications work together to effectively manage high blood pressure.
How does one take combination of hydrochlorothiazide and olmesartan?
Hydrochlorothiazide and olmesartan can be taken with or without food, according to personal preference. It's important to take them at the same time each day to maintain consistent blood levels. Patients should avoid excessive salt intake, as it can counteract the blood pressure-lowering effects. Drinking plenty of water is recommended to prevent dehydration, especially when taking hydrochlorothiazide. Always follow the healthcare provider's instructions and discuss any dietary concerns to ensure the best results.
How does one take combination of Hydrochlorothiazide and Olmesartan?
Hydrochlorothiazide and olmesartan can be taken with or without food, but it's important to take them at the same time each day to maintain consistent blood levels. Patients should avoid using salt substitutes containing potassium without consulting their doctor, as olmesartan can increase potassium levels. If prescribed a low-salt diet, it is crucial to follow these dietary instructions carefully. Staying hydrated is important, especially when taking hydrochlorothiazide, to prevent dehydration and maintain electrolyte balance.
For how long is combination of hydrochlorothiazide and olmesartan taken?
Hydrochlorothiazide and olmesartan are typically used as long-term treatments for managing high blood pressure. The duration of use depends on the individual's response and the healthcare provider's recommendations. Both medicines are often part of a lifelong treatment plan to maintain healthy blood pressure levels and reduce the risk of heart-related complications. Regular follow-ups with a healthcare provider are essential to monitor effectiveness and make any necessary adjustments to the treatment plan.
For how long is combination of Hydrochlorothiazide and Olmesartan taken?
Hydrochlorothiazide and olmesartan are typically used as long-term treatments for managing high blood pressure. While hydrochlorothiazide may be used intermittently for edema, olmesartan is generally taken continuously to maintain blood pressure control. Both medications are part of a long-term management plan for hypertension, and their use should be regularly reviewed by a healthcare provider to ensure effectiveness and adjust dosages as necessary. It's important to continue taking these medications even if you feel well, as they help prevent complications associated with high blood pressure.
How long does it take for combination of hydrochlorothiazide and olmesartan to work?
Hydrochlorothiazide, which is a diuretic that helps remove excess fluid from the body, usually starts working within a few hours of taking it. Olmesartan, which is an angiotensin receptor blocker that helps relax blood vessels, may take a few weeks to show its full effect in lowering blood pressure. Together, these medicines work to reduce blood pressure, but the noticeable effects on blood pressure may take a few weeks to be fully observed. It's important to continue taking the medicine as prescribed to achieve the best results.
How long does it take for combination of Hydrochlorothiazide and Olmesartan to work?
Hydrochlorothiazide and olmesartan, when used together, typically start to lower blood pressure within a week. Hydrochlorothiazide, a diuretic, begins to work within 2 hours, peaking around 4 hours, and lasts about 6 to 12 hours. Olmesartan, an angiotensin II receptor antagonist, may take up to 2 weeks to show its full effect, although some reduction in blood pressure can be noticed within the first week. The combination of these medications provides a more comprehensive approach to managing high blood pressure by addressing different mechanisms in the body.
Warnings and Precautions
Are there harms and risks from taking combination of hydrochlorothiazide and olmesartan?
Common side effects of hydrochlorothiazide include increased urination, dizziness, and electrolyte imbalances, which refer to changes in the levels of minerals in the blood. Olmesartan may cause dizziness, headache, and fatigue. Both medicines can lead to low blood pressure, which is a significant adverse effect. Rarely, olmesartan can cause kidney problems, while hydrochlorothiazide may lead to gout, which is a type of arthritis caused by excess uric acid. It's important to monitor for these side effects and consult a healthcare provider if they occur.
Are there harms and risks from taking combination of Hydrochlorothiazide and Olmesartan?
Common side effects of hydrochlorothiazide include frequent urination, dizziness, and electrolyte imbalances, such as low potassium levels. Olmesartan may cause dizziness, especially when standing up quickly, and in rare cases, severe diarrhea and weight loss. Both medications can lead to dehydration and low blood pressure if not monitored properly. Significant adverse effects include allergic reactions, kidney dysfunction, and, for olmesartan, a rare condition called sprue-like enteropathy. Patients should report any unusual symptoms to their healthcare provider promptly.
Can I take combination of hydrochlorothiazide and olmesartan with other prescription drugs?
Hydrochlorothiazide can interact with lithium, increasing the risk of lithium toxicity, which refers to harmful levels of lithium in the body. Olmesartan may interact with other blood pressure medications, leading to excessively low blood pressure. Both medicines can interact with NSAIDs, reducing their effectiveness in lowering blood pressure. It's important to inform healthcare providers of all medications being taken to avoid interactions. Regular monitoring of blood pressure and kidney function is essential to ensure safe use of hydrochlorothiazide and olmesartan.
Can I take combination of Hydrochlorothiazide and Olmesartan with other prescription drugs?
Significant drug interactions for hydrochlorothiazide and olmesartan include nonsteroidal anti-inflammatory drugs (NSAIDs), which can reduce their effectiveness and increase the risk of kidney damage. Combining these medications with other blood pressure-lowering drugs can enhance the antihypertensive effect, potentially leading to low blood pressure. Caution is advised when using lithium, as hydrochlorothiazide can increase lithium levels, leading to toxicity. Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions and ensure safe use.
Can I take combination of hydrochlorothiazide and olmesartan if I am pregnant?
Hydrochlorothiazide is generally not recommended during pregnancy as it can affect the balance of fluids and electrolytes in the mother and fetus. Olmesartan is contraindicated during pregnancy, especially in the second and third trimesters, as it can harm the developing fetus, potentially leading to kidney problems or even fetal death. Both medicines should be avoided during pregnancy, and alternative treatments should be discussed with a healthcare provider. If pregnancy occurs while taking these medicines, it's crucial to inform a healthcare provider immediately.
Can I take combination of Hydrochlorothiazide and Olmesartan if I am pregnant?
Hydrochlorothiazide and olmesartan are not recommended during pregnancy, particularly in the second and third trimesters, due to the risk of fetal harm. Olmesartan can cause injury or death to the developing fetus by affecting the renin-angiotensin system, leading to complications such as kidney failure and low blood pressure in the newborn. Hydrochlorothiazide may affect fetal electrolyte balance and blood volume. Women of childbearing age should use effective contraception while taking these medications and consult their healthcare provider if they become pregnant.
Can I take combination of hydrochlorothiazide and olmesartan while breastfeeding?
Hydrochlorothiazide is generally considered safe during breastfeeding in low doses, as it passes into breast milk in small amounts. However, high doses may reduce milk production. Olmesartan's safety during breastfeeding is not well established, and it is usually not recommended due to the potential risk to the infant. Both medicines should be used with caution during breastfeeding, and it's important to discuss with a healthcare provider to weigh the benefits and risks. Alternative treatments may be considered to ensure the safety of the nursing infant.
Can I take combination of Hydrochlorothiazide and Olmesartan while breastfeeding?
Hydrochlorothiazide is known to be excreted in breast milk in small amounts, and high doses can reduce milk production. Olmesartan's excretion in human milk is not well-documented, but it is present in animal milk. Due to potential adverse effects on the nursing infant, it is generally recommended to avoid these medications during breastfeeding or to use them with caution. If treatment is necessary, the lowest effective dose should be used, and the infant should be monitored for any adverse effects. Consulting a healthcare provider is essential for personalized advice.
Who should avoid taking combination of hydrochlorothiazide and olmesartan?
Hydrochlorothiazide should be used cautiously in people with kidney disease or gout, as it can worsen these conditions. Olmesartan is contraindicated in pregnancy due to potential harm to the fetus. Both medicines can cause low blood pressure, so they should be used carefully in people with a history of hypotension, which is abnormally low blood pressure. It's important to monitor blood pressure regularly and report any unusual symptoms to a healthcare provider. Patients should inform their healthcare provider of all medical conditions and medications to avoid potential risks.
Who should avoid taking combination of Hydrochlorothiazide and Olmesartan?
Hydrochlorothiazide and olmesartan should not be used during pregnancy, especially in the second and third trimesters, due to the risk of harm to the fetus. Patients with severe kidney impairment or anuria should avoid these medications. Caution is advised for those with liver disease, electrolyte imbalances, or a history of allergic reactions to sulfa drugs. Both medications can cause dizziness, so patients should avoid activities requiring alertness until they know how the drugs affect them. Regular monitoring of blood pressure and kidney function is essential to ensure safe use.
