Hydrochlorothiazide + Olmesartan
Find more information about this combination medication at the webpages for Hydrochlorothiazide and Olmesartan
Hypertension, Left Ventricular Dysfunction ... show more
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Advisory
- This medicine contains a combination of 2 drugs Hydrochlorothiazide and Olmesartan.
- Hydrochlorothiazide and Olmesartan are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Angiotensin 2 Receptor Blocker and Thiazide Diuretic
Controlled Drug Substance
NO
Summary
Hydrochlorothiazide and Olmesartan are primarily used to treat high blood pressure. Hydrochlorothiazide can also help with fluid buildup related to heart failure, liver cirrhosis, and kidney disorders. Olmesartan can be used in managing heart failure and diabetic nephropathy, a type of kidney damage that can occur in people with diabetes.
Hydrochlorothiazide works by helping your kidneys remove more sodium and water from your body, which helps to reduce blood pressure. Olmesartan works by relaxing your blood vessels, allowing blood to flow more easily, which also helps to lower blood pressure.
Hydrochlorothiazide is typically taken at a dose of 12.5 to 50 mg once daily. Olmesartan usually starts at a dose of 20 mg once daily, which can be increased to 40 mg if needed. When combined, the typical starting dose is 20 mg of Olmesartan with 12.5 mg of Hydrochlorothiazide taken once daily.
Common side effects of Hydrochlorothiazide include frequent urination, dizziness, and low potassium levels. Olmesartan may cause dizziness, especially when standing up quickly, and in rare cases, severe diarrhea and weight loss. Both medications can lead to dehydration and low blood pressure if not properly monitored.
These medications should not be used during pregnancy, especially in the second and third trimesters, due to the risk of harm to the fetus. They should also be avoided in patients with severe kidney impairment. Caution is advised for those with liver disease, electrolyte imbalances, or a history of allergic reactions to sulfa drugs.
Indications and Purpose
How does combination of Hydrochlorothiazide and Olmesartan work?
Hydrochlorothiazide works by increasing the excretion of sodium and water through the kidneys, which reduces fluid volume and lowers blood pressure. Olmesartan blocks the action of angiotensin II, a substance that narrows blood vessels, thereby relaxing the vessels and improving blood flow. Together, they provide a dual mechanism for controlling high blood pressure: hydrochlorothiazide reduces fluid retention, while olmesartan decreases vascular resistance. This combination effectively lowers blood pressure and reduces the risk of cardiovascular complications.
How effective is combination of Hydrochlorothiazide and Olmesartan?
Clinical trials have demonstrated that hydrochlorothiazide and olmesartan effectively lower blood pressure, reducing the risk of cardiovascular events such as strokes and heart attacks. Hydrochlorothiazide has been shown to decrease fluid retention and improve blood pressure control, while olmesartan effectively relaxes blood vessels by blocking angiotensin II. Together, they provide a comprehensive approach to managing hypertension, with studies indicating significant reductions in blood pressure when used in combination. The combination therapy is well-tolerated and offers an additive effect, enhancing the overall antihypertensive benefit.
Directions for Use
What is the usual dose of combination of Hydrochlorothiazide and Olmesartan?
The usual adult daily dose for hydrochlorothiazide when used alone is typically 12.5 to 50 mg, taken once daily. For olmesartan, the usual starting dose is 20 mg once daily, which can be increased to 40 mg if needed. When combined, the typical starting dose is 20 mg of olmesartan with 12.5 mg of hydrochlorothiazide, taken once daily. This combination can be adjusted based on the patient's response and tolerance, with a maximum dose of 40 mg olmesartan and 25 mg hydrochlorothiazide per day. Both medications work together to effectively manage high blood pressure.
How does one take combination of Hydrochlorothiazide and Olmesartan?
Hydrochlorothiazide and olmesartan can be taken with or without food, but it's important to take them at the same time each day to maintain consistent blood levels. Patients should avoid using salt substitutes containing potassium without consulting their doctor, as olmesartan can increase potassium levels. If prescribed a low-salt diet, it is crucial to follow these dietary instructions carefully. Staying hydrated is important, especially when taking hydrochlorothiazide, to prevent dehydration and maintain electrolyte balance.
For how long is combination of Hydrochlorothiazide and Olmesartan taken?
Hydrochlorothiazide and olmesartan are typically used as long-term treatments for managing high blood pressure. While hydrochlorothiazide may be used intermittently for edema, olmesartan is generally taken continuously to maintain blood pressure control. Both medications are part of a long-term management plan for hypertension, and their use should be regularly reviewed by a healthcare provider to ensure effectiveness and adjust dosages as necessary. It's important to continue taking these medications even if you feel well, as they help prevent complications associated with high blood pressure.
How long does it take for combination of Hydrochlorothiazide and Olmesartan to work?
Hydrochlorothiazide and olmesartan, when used together, typically start to lower blood pressure within a week. Hydrochlorothiazide, a diuretic, begins to work within 2 hours, peaking around 4 hours, and lasts about 6 to 12 hours. Olmesartan, an angiotensin II receptor antagonist, may take up to 2 weeks to show its full effect, although some reduction in blood pressure can be noticed within the first week. The combination of these medications provides a more comprehensive approach to managing high blood pressure by addressing different mechanisms in the body.
Warnings and Precautions
Are there harms and risks from taking combination of Hydrochlorothiazide and Olmesartan?
Common side effects of hydrochlorothiazide include frequent urination, dizziness, and electrolyte imbalances, such as low potassium levels. Olmesartan may cause dizziness, especially when standing up quickly, and in rare cases, severe diarrhea and weight loss. Both medications can lead to dehydration and low blood pressure if not monitored properly. Significant adverse effects include allergic reactions, kidney dysfunction, and, for olmesartan, a rare condition called sprue-like enteropathy. Patients should report any unusual symptoms to their healthcare provider promptly.
Can I take combination of Hydrochlorothiazide and Olmesartan with other prescription drugs?
Significant drug interactions for hydrochlorothiazide and olmesartan include nonsteroidal anti-inflammatory drugs (NSAIDs), which can reduce their effectiveness and increase the risk of kidney damage. Combining these medications with other blood pressure-lowering drugs can enhance the antihypertensive effect, potentially leading to low blood pressure. Caution is advised when using lithium, as hydrochlorothiazide can increase lithium levels, leading to toxicity. Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions and ensure safe use.
Can I take combination of Hydrochlorothiazide and Olmesartan if I am pregnant?
Hydrochlorothiazide and olmesartan are not recommended during pregnancy, particularly in the second and third trimesters, due to the risk of fetal harm. Olmesartan can cause injury or death to the developing fetus by affecting the renin-angiotensin system, leading to complications such as kidney failure and low blood pressure in the newborn. Hydrochlorothiazide may affect fetal electrolyte balance and blood volume. Women of childbearing age should use effective contraception while taking these medications and consult their healthcare provider if they become pregnant.
Can I take combination of Hydrochlorothiazide and Olmesartan while breastfeeding?
Hydrochlorothiazide is known to be excreted in breast milk in small amounts, and high doses can reduce milk production. Olmesartan's excretion in human milk is not well-documented, but it is present in animal milk. Due to potential adverse effects on the nursing infant, it is generally recommended to avoid these medications during breastfeeding or to use them with caution. If treatment is necessary, the lowest effective dose should be used, and the infant should be monitored for any adverse effects. Consulting a healthcare provider is essential for personalized advice.
Who should avoid taking combination of Hydrochlorothiazide and Olmesartan?
Hydrochlorothiazide and olmesartan should not be used during pregnancy, especially in the second and third trimesters, due to the risk of harm to the fetus. Patients with severe kidney impairment or anuria should avoid these medications. Caution is advised for those with liver disease, electrolyte imbalances, or a history of allergic reactions to sulfa drugs. Both medications can cause dizziness, so patients should avoid activities requiring alertness until they know how the drugs affect them. Regular monitoring of blood pressure and kidney function is essential to ensure safe use.
