Gliclazide
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Drug Status
Government Approvals
UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
Sulfonylurea
Controlled Drug Substance
NO
Gliclazide
Learn more about this medicine -
Click HereSummary
Gliclazide is used to control high blood sugar levels in people with type 2 diabetes. It helps reduce the risk of complications like nerve damage, kidney disease, and heart problems.
Gliclazide works by stimulating the pancreas to release more insulin, which helps lower blood glucose levels. It also improves blood flow by reducing clot formation.
The usual adult dose of Gliclazide ranges from 40 mg to 320 mg daily. It's often divided into one or two doses. Extended-release formulations are taken once daily. It's an oral medication, not recommended for children.
Common side effects of Gliclazide include low blood sugar (hypoglycemia), nausea, headache, and weight gain. Rarely, serious side effects like liver issues or blood disorders can occur.
Avoid Gliclazide if you have type 1 diabetes, severe liver or kidney problems, or a history of allergic reactions to sulfonylureas. It's generally not recommended during pregnancy or breastfeeding. Always consult your doctor before use.
Indications and Purpose
What is Gliclazide used for?
Gliclazide is used to control high blood sugar levels in patients with type 2 diabetes, reducing the risk of complications like nerve damage, kidney disease, and heart problems.
How does Gliclazide work?
Gliclazide stimulates the pancreas to release more insulin, which helps lower blood sugar levels. It also improves blood flow by reducing clot formation.
Is Gliclazide effective?
Yes, studies show that gliclazide effectively reduces blood sugar levels and improves long-term diabetes management when combined with diet and exercise.
How does one know if Gliclazide is working?
Improved blood sugar readings and reduced diabetes-related symptoms like excessive thirst and fatigue indicate the medicine is working. Regular tests, such as HbA1c, help monitor progress.
Directions for Use
What is the usual dose of Gliclazide?
The usual adult dose ranges from 40 mg to 320 mg daily, often divided into one or two doses. Extended-release formulations are taken once daily. It is not recommended for children.
How do I take Gliclazide?
Take gliclazide as prescribed, usually with food to avoid low blood sugar. Do not skip meals while using this medicine. Avoid alcohol, as it can affect blood sugar levels.
For how long do I take Gliclazide?
Gliclazide is typically taken long-term as part of ongoing diabetes management. Regular monitoring of blood sugar levels helps determine its duration.
How long does it take for Gliclazide to start working?
Gliclazide begins to lower blood sugar levels within a few hours of taking a dose. Full effects on blood sugar control may take a few days to weeks.
How should I store Gliclazide?
Store gliclazide at room temperature, away from moisture and heat. Keep it out of reach of children and pets.
Warnings and Precautions
Who should avoid taking Gliclazide?
Avoid gliclazide if you have type 1 diabetes, severe liver or kidney problems, or a history of allergic reactions to sulfonylureas. Pregnant or breastfeeding women should consult their doctor before use.
Can I take Gliclazide with other prescription drugs?
Gliclazide interacts with several drugs, including insulin, blood thinners, and certain antibiotics, which may enhance or reduce its effects. Always inform your doctor about all medications you're using.
Can I take Gliclazide with vitamins or supplements?
Some supplements may affect blood sugar levels, such as vitamin C, chromium, or herbal remedies. Inform your doctor about all supplements you're taking to prevent interactions.
Can Gliclazide be taken safely while pregnant?
Gliclazide is generally not recommended during pregnancy. Insulin is often a safer alternative. Discuss with your doctor if you are pregnant or planning to conceive.
Can Gliclazide be taken safely while breastfeeding?
It is not usually recommended while breastfeeding, as it may pass into breast milk and affect the baby. Consult your doctor for alternatives.
Is Gliclazide safe for the elderly?
Yes, but elderly patients should be closely monitored, as they are more prone to hypoglycemia and its effects. Dose adjustments may be necessary.
Is it safe to exercise while taking Gliclazide?
Yes, exercise is beneficial for managing diabetes. However, monitor blood sugar levels, especially before and after exercising, to prevent hypoglycemia while on gliclazide.
Is it safe to drink alcohol while taking Gliclazide?
Alcohol can increase the risk of low blood sugar. Limit alcohol intake, and never drink on an empty stomach while taking gliclazide. Always consult your doctor for advice.
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