Gilteritinib
Acute Myeloid Leukemia
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Summary
Gilteritinib is used to treat acute myeloid leukemia, which is a type of cancer affecting the blood and bone marrow. It is specifically for patients with a certain genetic mutation that helps the cancer cells grow.
Gilteritinib works by blocking proteins called kinases, which are responsible for the growth and division of cancer cells. By inhibiting these proteins, it slows down the progression of the disease and reduces the number of cancer cells.
The usual starting dose of gilteritinib for adults is 120 mg taken once daily. It can be taken with or without food, and the tablet should be swallowed whole, not crushed or chewed.
Common side effects of gilteritinib include fatigue, nausea, and diarrhea. These effects vary among individuals, and if new symptoms arise, it's important to consult a doctor to determine if they are related to the medication.
Gilteritinib can increase the risk of serious side effects like differentiation syndrome, which is a potentially life-threatening condition with symptoms like fever and breathing difficulties. It can also cause liver problems, so regular liver function tests are recommended.
Indications and Purpose
How does gilteritinib work?
Gilteritinib works by blocking certain proteins called kinases, which help cancer cells grow and divide. Think of it like turning off a switch that powers cancer cell growth. By inhibiting these proteins, gilteritinib slows down the progression of acute myeloid leukemia, which is a cancer of the blood and bone marrow. This helps reduce the number of cancer cells in your body and can improve your symptoms.
Is gilteritinib effective?
Gilteritinib is effective for treating certain types of acute myeloid leukemia, which is a cancer of the blood and bone marrow. Clinical studies show that gilteritinib can improve survival rates and reduce cancer cell growth in patients with specific genetic mutations. The effectiveness of gilteritinib depends on individual health conditions and genetic factors. Regular monitoring by your doctor will help assess the medication's effectiveness for your specific situation.
What is gilteritinib?
Gilteritinib is a medication used to treat acute myeloid leukemia, which is a cancer of the blood and bone marrow. It belongs to a class of drugs called kinase inhibitors, which work by blocking certain proteins that help cancer cells grow. Gilteritinib is specifically used for patients with a specific genetic mutation. It helps slow the progression of the disease and can be used alone or with other therapies.
Directions for Use
For how long do I take gilteritinib?
Gilteritinib is usually a long-term medication for managing certain types of acute myeloid leukemia, which is a cancer of the blood and bone marrow. The duration of use depends on your response to the medication and any side effects you experience. Your doctor will regularly assess your condition and adjust your treatment plan as needed. Always talk with your doctor before changing or stopping your gilteritinib treatment.
How do I dispose of gilteritinib?
To dispose of gilteritinib, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take gilteritinib?
Gilteritinib is usually taken once daily. You can take it with or without food. It's important to swallow the tablet whole and not crush or chew it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Always follow your doctor's specific instructions regarding your medication.
How long does it take for gilteritinib to start working?
Gilteritinib begins working in your body shortly after you take it, but the time it takes to see noticeable effects can vary. Some patients may notice improvements in symptoms within a few weeks, while others may take longer. The full therapeutic effect may take several months. How quickly the medication works can depend on individual factors like your overall health and the specific characteristics of your leukemia. Regular monitoring by your doctor will help assess the medication's effectiveness.
How should I store gilteritinib?
Store gilteritinib at room temperature, away from moisture and light. Keep it in its original container with the lid tightly closed. Avoid storing it in humid places like bathrooms. If your pills came in packaging that isn't child-resistant, transfer them to a container that children can't easily open. Always store gilteritinib out of children's reach to prevent accidental swallowing. Check the expiration date regularly and dispose of any unused or expired medication properly.
What is the usual dose of gilteritinib?
The usual starting dose of gilteritinib for adults is 120 mg taken once daily. Your doctor may adjust your dose based on your response to the medication and any side effects you experience. It's important to follow your doctor's specific dosing instructions. Gilteritinib is not typically used in children, and elderly patients may require careful monitoring. Always consult your doctor for personalized dosing advice.
Warnings and Precautions
Can gilteritinib be taken safely while breastfeeding?
Gilteritinib is not recommended while breastfeeding. There is limited information on whether this medication passes into human breast milk. However, it could potentially affect a baby's development. If you're taking gilteritinib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely. Your doctor can help you make informed decisions about your treatment and breastfeeding.
Can gilteritinib be taken safely while pregnant?
Gilteritinib is not recommended during pregnancy due to potential risks to the unborn baby. There is limited information on its safety in pregnant women, but animal studies suggest it could harm fetal development. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options. Your doctor can help create a pregnancy-specific treatment plan that protects both you and your baby.
Can I take gilteritinib with other prescription drugs?
Gilteritinib can interact with certain medications, increasing the risk of side effects or reducing its effectiveness. For example, drugs that affect liver enzymes can alter gilteritinib levels in your body. Always inform your doctor about all the medications you are taking, including over-the-counter drugs and supplements. Your doctor will help manage any potential interactions to ensure your treatment is safe and effective.
Does gilteritinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of gilteritinib include fatigue, nausea, and diarrhea. Serious side effects can include liver problems and differentiation syndrome, which is a potentially life-threatening condition. If you experience any new or worsening symptoms while taking gilteritinib, contact your doctor immediately. Regular monitoring and communication with your healthcare provider can help manage any adverse effects.
Does gilteritinib have any safety warnings?
Yes, gilteritinib has important safety warnings. It can increase the risk of serious side effects like differentiation syndrome, which is a potentially life-threatening condition. Symptoms include fever, weight gain, and breathing difficulties. Gilteritinib can also cause liver problems, so regular liver function tests are recommended. Not adhering to these warnings can lead to severe health issues. Always follow your doctor's advice and report any unusual symptoms immediately.
Is gilteritinib addictive?
Gilteritinib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Gilteritinib works by targeting specific proteins in cancer cells and doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, gilteritinib doesn't carry this risk.
Is gilteritinib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of gilteritinib, such as liver problems and fatigue. It's important for older adults to be closely monitored by their healthcare provider while taking this medication. Regular check-ups and communication with your doctor can help manage any potential risks. Your doctor will consider your overall health and any other medications you are taking when prescribing gilteritinib.
Is it safe to drink alcohol while taking gilteritinib?
It's best to avoid alcohol while taking gilteritinib. Alcohol can increase the risk of liver problems, which is a potential side effect of gilteritinib. Drinking alcohol may also worsen other side effects like dizziness or nausea. If you do choose to drink occasionally, limit how much alcohol you consume and watch for any warning signs. Talk with your doctor about alcohol use while taking gilteritinib to get personalized advice.
Is it safe to exercise while taking gilteritinib?
You can exercise while taking gilteritinib, but be cautious. This medication can cause fatigue and dizziness, which might affect your ability to exercise. To exercise safely, listen to your body and avoid strenuous activities if you feel unwell. Drink plenty of water before, during, and after physical activity. If you notice symptoms like dizziness or unusual fatigue, slow down or stop exercising and rest. Consult your doctor if you have concerns.
Is it safe to stop gilteritinib?
Stopping gilteritinib suddenly can affect your treatment outcome. It's used for long-term management of certain cancers, and stopping it without medical advice could worsen your condition. Always talk with your doctor before stopping gilteritinib. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely.
What are the most common side effects of gilteritinib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of gilteritinib include fatigue, nausea, and diarrhea. These effects vary from person to person. If you notice new symptoms after starting gilteritinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication. Your doctor can help determine if the side effects are related to gilteritinib.
Who should avoid taking gilteritinib?
Gilteritinib should not be used if you are allergic to it or any of its ingredients. Serious allergic reactions require immediate medical help. Caution is needed if you have liver problems, as gilteritinib can affect liver function. Always inform your doctor about your medical history and any other medications you are taking. Your doctor will weigh the benefits and risks before prescribing gilteritinib.
