Gemfibrozil
Coronary Artery Disease, Hypercholesterolemia ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Peroxisome Proliferator Receptor alpha Agonist
Controlled Drug Substance
No
gemfibrozil
Summary
Gemfibrozil is used to lower very high triglyceride levels, which are fats in the blood, to reduce the risk of pancreatitis, which is inflammation of the pancreas. It also helps lower cholesterol levels in people who cannot take statins, which are another type of cholesterol-lowering medication.
Gemfibrozil works by reducing the production of triglycerides and cholesterol in the liver, which is an organ that processes nutrients and filters waste. It increases the breakdown of fats in the blood, helping to lower triglyceride levels and improve heart health.
The usual dose of Gemfibrozil for adults is 600 mg taken twice daily, 30 minutes before breakfast and dinner. It is important to take it on an empty stomach for the best effect. Always follow your doctor's instructions regarding dosage.
Common side effects of Gemfibrozil include stomach upset, which refers to discomfort in the stomach, diarrhea, which is loose or watery stools, and fatigue, which is a feeling of tiredness. These effects are usually mild and may go away on their own.
Gemfibrozil should not be taken with statins due to the risk of muscle problems. It is contraindicated in people with liver or severe kidney disease, which are conditions affecting organs that filter waste from the blood. Always consult your doctor about potential interactions.
Indications and Purpose
How does Gemfibrozil work?
Gemfibrozil works by reducing the production of triglycerides and cholesterol in the liver. It increases the breakdown of fats in the blood, which helps lower triglyceride levels. Think of it like a filter that helps remove excess fat from your bloodstream. This process helps reduce the risk of pancreatitis and manage cholesterol levels, which can improve heart health.
Is Gemfibrozil effective?
Gemfibrozil is effective in lowering triglycerides and cholesterol levels in the blood. It helps reduce the risk of pancreatitis, which is inflammation of the pancreas, in people with very high triglyceride levels. Clinical studies show that Gemfibrozil can significantly improve lipid profiles, which are measures of fat in the blood, and help manage conditions related to high cholesterol and triglycerides.
What is Gemfibrozil?
Gemfibrozil is a medication used to lower cholesterol and triglyceride levels in the blood. It belongs to a class of drugs called fibrates, which work by reducing the amount of fat produced by the liver. Gemfibrozil is primarily used to treat very high triglyceride levels, which can reduce the risk of pancreatitis. It may also be used to lower cholesterol levels in people who cannot take statins.
Directions for Use
For how long do I take Gemfibrozil?
Gemfibrozil is usually a long-term medication for managing high cholesterol and triglyceride levels. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your conditions to worsen. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your Gemfibrozil treatment.
How do I dispose of Gemfibrozil?
If you can, bring unused Gemfibrozil to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Gemfibrozil?
Take Gemfibrozil as prescribed by your doctor, usually twice daily, 30 minutes before breakfast and dinner. Do not crush or chew the tablets. It's important to take it on an empty stomach for the best effect. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Avoid taking two doses at once.
How long does it take for Gemfibrozil to start working?
Gemfibrozil begins working in your body shortly after you take it, but it may take several weeks to see the full effects on your cholesterol and triglyceride levels. Your doctor will monitor your blood levels to see how well the medication is working. Individual factors like diet, exercise, and overall health can affect how quickly you see results. Take it exactly as prescribed for the best results.
How should I store Gemfibrozil?
Store Gemfibrozil at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in the bathroom, where humidity can affect the medication. If your pills came in packaging that isn't child-resistant, transfer them to a container that children can't easily open. Always store Gemfibrozil out of children's reach to prevent accidental swallowing.
What is the usual dose of Gemfibrozil?
The usual dose of Gemfibrozil for adults is 600 mg taken twice daily, 30 minutes before breakfast and dinner. Your doctor may adjust your dose based on your specific health needs. It's important to follow your doctor's instructions and not to change your dose without consulting them. Gemfibrozil is not typically used in children, and elderly patients may require careful monitoring.
Warnings and Precautions
Can Gemfibrozil be taken safely while breastfeeding?
Gemfibrozil is not recommended while breastfeeding. There's limited information on whether it passes into human breast milk. While we don't have specific reports of harm to breastfed babies, potential risks can't be ruled out. If you're taking Gemfibrozil and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Gemfibrozil be taken safely while pregnant?
Gemfibrozil is not recommended during pregnancy due to limited evidence on its safety. Animal studies suggest potential risks, but human data is lacking. Uncontrolled cholesterol levels during pregnancy can cause complications. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your cholesterol. Your doctor can help create a pregnancy-specific treatment plan.
Can I take Gemfibrozil with other prescription drugs?
Gemfibrozil can interact with several medications, increasing the risk of adverse effects. It should not be taken with statins, which are cholesterol-lowering drugs, as this increases the risk of muscle problems. It can also interact with blood thinners like warfarin, increasing bleeding risk. Always inform your doctor about all medications you are taking to avoid harmful interactions.
Does Gemfibrozil have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Gemfibrozil include stomach upset, diarrhea, and fatigue. Serious side effects can include muscle pain or weakness, which may indicate a condition called rhabdomyolysis, and liver problems. If you notice any new or worsening symptoms, contact your doctor immediately. Regular monitoring can help manage these risks.
Does Gemfibrozil have any safety warnings?
Yes, Gemfibrozil has important safety warnings. It can increase the risk of muscle problems, especially when taken with certain other medications. It may also affect liver function, so regular monitoring is important. Not adhering to these warnings can lead to serious health issues. Always follow your doctor's advice and report any unusual symptoms immediately.
Is Gemfibrozil addictive?
Gemfibrozil is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. It works by affecting the liver to help lower cholesterol and triglycerides, which doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Gemfibrozil safe for the elderly?
Elderly individuals are more vulnerable to the side effects of medications like Gemfibrozil. They may experience muscle problems or liver issues more frequently. It's important for elderly patients to have regular check-ups and monitoring while taking this medication. Your doctor may adjust the dose or recommend additional precautions to ensure safety.
Is it safe to drink alcohol while taking Gemfibrozil?
It's best to avoid alcohol while taking Gemfibrozil. Alcohol can increase the risk of liver problems, which are a concern with this medication. Drinking alcohol may also worsen side effects like stomach upset. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like nausea or abdominal pain. Talk with your doctor about alcohol use while taking Gemfibrozil.
Is it safe to exercise while taking Gemfibrozil?
You can exercise while taking Gemfibrozil, but be mindful of how your body feels. This medication can cause muscle pain or weakness, which might affect your ability to exercise. If you experience these symptoms, slow down or stop exercising and rest. Most people can maintain their regular exercise routine while taking Gemfibrozil, but check with your doctor if you have concerns.
Is it safe to stop Gemfibrozil?
It's important not to stop Gemfibrozil suddenly without consulting your doctor. Stopping it abruptly can lead to a rise in cholesterol and triglyceride levels, which can increase the risk of heart disease. Your doctor may suggest a gradual reduction or an alternative treatment plan to manage your condition safely. Always follow your doctor's guidance when making changes to your medication.
What are the most common side effects of Gemfibrozil?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Gemfibrozil include stomach upset, diarrhea, and fatigue. These effects vary from person to person. If you notice new symptoms after starting Gemfibrozil, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Gemfibrozil?
Don't take Gemfibrozil if you're allergic to it or its ingredients. It's contraindicated in people with liver or severe kidney disease, which are conditions affecting organs that filter waste from your blood. Gemfibrozil shouldn't be used with certain cholesterol-lowering medications like statins, as it increases the risk of muscle problems. Always consult your doctor about these concerns.
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