Galcanezumab
Cluster Headache
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Summary
Galcanezumab is used to prevent migraines, which are severe headaches that can cause intense pain and other symptoms. It helps reduce the frequency and severity of these migraine attacks, making it a preventive treatment for people who experience frequent migraines.
Galcanezumab works by blocking a protein called calcitonin gene-related peptide (CGRP), which is involved in the development of migraines. By inhibiting this protein, it helps prevent the onset of migraine attacks, reducing their frequency and severity.
Galcanezumab is typically administered as an injection. The usual starting dose for adults is 240 mg as a loading dose, followed by 120 mg once a month. It can be taken with or without food, and it's important to follow your doctor's specific dosing instructions.
Common adverse effects of galcanezumab include injection site reactions, such as pain, redness, or swelling. These occur in a small percentage of users. Serious adverse effects are rare but can include allergic reactions, which require immediate medical attention.
Galcanezumab may cause serious allergic reactions, which include symptoms like rash, itching, or swelling of the face, tongue, or throat. If you experience these, seek medical help immediately. Always inform your doctor about any allergies or medical conditions before starting galcanezumab.
Indications and Purpose
How does galcanezumab work?
Galcanezumab works by targeting and blocking a protein called calcitonin gene-related peptide (CGRP), which is involved in the development of migraines. By inhibiting this protein, galcanezumab helps prevent the onset of migraine attacks. Think of it like a lock and key, where galcanezumab acts as a key that blocks the lock (CGRP), preventing it from triggering migraines. This action helps reduce the frequency and severity of migraines.
Is galcanezumab effective?
Yes, galcanezumab is effective for preventing migraines. Clinical studies show it significantly reduces the frequency of migraine days in people who suffer from these headaches. It works by blocking a protein involved in migraine development. Many users experience fewer migraines and improved quality of life. If you have questions about its effectiveness for your condition, discuss them with your doctor.
What is galcanezumab?
Galcanezumab is a medication used to prevent migraines. It belongs to a class of drugs called monoclonal antibodies, which target specific proteins in the body. Galcanezumab works by blocking a protein involved in the development of migraines, helping to reduce their frequency and severity. It's used as a preventive treatment for people who experience frequent migraines. Always follow your doctor's instructions when using this medication.
Directions for Use
For how long do I take galcanezumab?
Galcanezumab is usually a long-term medication for preventing migraines. You'll typically take it once a month as part of an ongoing treatment plan. The duration of use depends on your response to the medication and your doctor's recommendations. Always talk with your doctor before changing or stopping your galcanezumab treatment to ensure your migraines remain well-managed.
How do I dispose of galcanezumab?
Dispose of unused galcanezumab through a drug take-back program or collection site at a pharmacy or hospital. This ensures safe disposal without harming people or the environment. If a take-back program isn't available, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away.
How do I take galcanezumab?
Galcanezumab is typically administered as an injection. It's usually given once a month. You can take it with or without food. If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Always follow your doctor's specific instructions on how to take galcanezumab, including any dietary or beverage restrictions.
How long does it take for galcanezumab to start working?
Galcanezumab may start reducing migraine frequency within a month of starting treatment. However, it can take several months to achieve its full therapeutic effect. Individual responses vary, and some people may notice improvements sooner than others. Factors like overall health and adherence to the treatment plan can affect how quickly you see results. Always take galcanezumab as prescribed for the best outcomes.
How should I store galcanezumab?
Store galcanezumab in the refrigerator between 36°F to 46°F. Keep it in its original packaging to protect it from light. Do not freeze it. If needed, galcanezumab can be kept at room temperature for up to 7 days, but it should be used within this time. Always keep it out of reach of children. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of galcanezumab?
The usual starting dose of galcanezumab for adults is 240 mg as a loading dose, followed by 120 mg once a month. This medication is administered as an injection. Your doctor may adjust the dose based on your response to the treatment. Always follow your doctor's specific dosing instructions. There are no established dose adjustments for children or the elderly, so it's important to consult your healthcare provider for personalized advice.
Warnings and Precautions
Can galcanezumab be taken safely while breastfeeding?
The safety of galcanezumab while breastfeeding is not well-established. It's unclear if the medication passes into breast milk. If you're breastfeeding or planning to breastfeed, talk with your doctor before using galcanezumab. They can help assess the potential risks and benefits and suggest safer alternatives if necessary to ensure your baby's health and your treatment needs are met.
Can galcanezumab be taken safely while pregnant?
The safety of galcanezumab during pregnancy is not well-established. There is limited information on its effects on pregnant women. Always discuss with your doctor if you are pregnant or planning to become pregnant while considering galcanezumab. They can help weigh the potential benefits and risks and decide the best course of action for your health and your baby's safety.
Can I take galcanezumab with other prescription drugs?
There are no major or moderate drug interactions specifically associated with galcanezumab. However, always inform your doctor about all medications you are taking to avoid potential interactions. This includes prescription drugs, over-the-counter medications, and supplements. Your doctor can help ensure your treatment is safe and effective by considering all possible interactions.
Does galcanezumab have adverse effects?
Adverse effects are unwanted reactions to a medication. With galcanezumab, common adverse effects include injection site reactions like pain or redness. These occur in a small percentage of users. Serious adverse effects are rare but can include allergic reactions. If you notice any new or worsening symptoms, contact your doctor. They can help determine if these are related to the medication and advise on appropriate actions.
Does galcanezumab have any safety warnings?
Yes, galcanezumab has safety warnings. It may cause allergic reactions, which can be serious. Symptoms include rash, itching, or swelling, especially of the face, tongue, or throat. If you experience these, seek medical help immediately. Not adhering to safety warnings can lead to severe consequences, including life-threatening reactions. Always inform your doctor about any allergies or medical conditions before starting galcanezumab.
Is galcanezumab addictive?
Galcanezumab is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. This medication works by targeting specific proteins involved in migraine development and does not affect brain chemistry in a way that leads to addiction. You won't experience cravings for galcanezumab or feel compelled to take more than prescribed. If you have concerns about medication dependence, rest assured that galcanezumab does not carry this risk.
Is galcanezumab safe for the elderly?
Galcanezumab is generally safe for the elderly, but they may be more vulnerable to side effects due to age-related changes in the body. Elderly users should be monitored for any adverse reactions, especially injection site reactions. Always consult a doctor before starting galcanezumab to ensure it's appropriate for the individual's health condition and to discuss any potential risks.
Is it safe to drink alcohol while taking galcanezumab?
There are no well-established interactions between galcanezumab and alcohol. However, it's generally advisable to limit alcohol consumption while taking any medication. Alcohol can trigger migraines in some people, which galcanezumab is used to prevent. If you choose to drink, do so in moderation and monitor how your body responds. Discuss any concerns with your doctor for personalized advice.
Is it safe to exercise while taking galcanezumab?
Yes, it's safe to exercise while taking galcanezumab. This medication does not typically limit exercise capacity. However, if you experience any unusual symptoms during physical activity, such as dizziness or fatigue, slow down or stop and rest. Most people can maintain their regular exercise routine while on galcanezumab. If you have specific concerns, discuss them with your doctor.
Is it safe to stop galcanezumab?
Galcanezumab is usually used for long-term prevention of migraines. Stopping it suddenly may lead to a return of migraine symptoms. There are no known withdrawal symptoms from stopping galcanezumab. However, always talk with your doctor before stopping the medication. They can guide you on how to safely discontinue use or adjust your treatment plan to manage your condition effectively.
What are the most common side effects of galcanezumab?
Side effects are unwanted reactions to a medication. Common side effects of galcanezumab include injection site reactions, such as pain, redness, or swelling. These occur in a small percentage of people. If you experience new symptoms after starting galcanezumab, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication.
Who should avoid taking galcanezumab?
Galcanezumab should not be used if you are allergic to it or any of its ingredients. Serious allergic reactions, which cause rash, hives, or swelling that makes breathing difficult, require immediate medical help. There are no specific contraindications related to other medical conditions, but always inform your doctor about your health history. They can determine if galcanezumab is safe for you.
