Fosinopril + Hydrochlorothiazide
Find more information about this combination medication at the webpages for fosinopril and hydrochlorothiazide
Hypertension , Left Ventricular Dysfunction ... show more
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Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Angiotensin Converting Enzyme Inhibitor and Thiazide Diuretic
Controlled Drug Substance
NO
Summary
Fosinopril and hydrochlorothiazide are used to treat high blood pressure, which is also known as hypertension. High blood pressure is a condition where the force of the blood against the artery walls is too high, which can lead to heart disease and stroke if not managed properly. By lowering blood pressure, these medications help reduce the risk of heart attacks and strokes.
Fosinopril is an ACE inhibitor, which helps relax blood vessels by blocking a substance that causes them to tighten. This makes it easier for the heart to pump blood. Hydrochlorothiazide is a diuretic, which helps the body get rid of excess salt and water by increasing urine production. Together, they lower blood pressure more effectively than either drug alone.
The usual starting dose for the combination of fosinopril and hydrochlorothiazide is often 10 mg of fosinopril and 12.5 mg of hydrochlorothiazide taken once daily. It is important to follow a healthcare provider's instructions, as they may adjust the dose based on individual health needs and how well the medication is working. The medication is taken orally, which means by mouth.
Common side effects of fosinopril and hydrochlorothiazide include dizziness, lightheadedness, and dehydration. These effects are more likely to occur when you first start taking the medication or if your dose is increased. It's important to stay hydrated and contact your doctor if these symptoms persist or worsen. Monitoring your blood pressure regularly can help manage these side effects.
Fosinopril and hydrochlorothiazide should not be taken by people who are allergic to either medication or have severe kidney or liver disease. Pregnant women should avoid fosinopril, as it can harm the unborn baby. People with a history of angioedema, which is swelling under the skin, related to ACE inhibitors should also avoid fosinopril. Always consult a healthcare provider before starting or stopping any medication.
Indications and Purpose
How does combination of Fosinopril and Hydrochlorothiazide work?
Fosinopril and Hydrochlorothiazide work together to help lower high blood pressure. Fosinopril is an "ACE inhibitor," which means it helps relax blood vessels by blocking a substance in the body that causes them to tighten. This makes it easier for the heart to pump blood. Hydrochlorothiazide is a "diuretic," often called a water pill, which helps the body get rid of extra salt and water by making you urinate more. This reduces the amount of fluid in the blood vessels, which also helps lower blood pressure. Together, these medications help prevent strokes, heart attacks, and kidney problems by keeping blood pressure under control.
How does combination of Hydrochlorothiazide and Fosinopril work?
Fosinopril works by inhibiting the angiotensin-converting enzyme (ACE), which decreases the production of angiotensin II, a substance that narrows blood vessels. This leads to vasodilation, allowing blood to flow more easily and reducing blood pressure. Hydrochlorothiazide, a diuretic, helps the kidneys remove excess water and salt from the body, reducing fluid retention and blood pressure. Together, they provide a dual approach to managing hypertension by addressing both vascular resistance and fluid balance.
How effective is combination of Fosinopril and Hydrochlorothiazide?
The combination of Fosinopril and Hydrochlorothiazide is used to treat high blood pressure. Fosinopril is an ACE inhibitor, which helps relax blood vessels, making it easier for the heart to pump blood. Hydrochlorothiazide is a diuretic, often called a 'water pill,' that helps reduce excess fluid in the body by increasing urine production. Together, they work effectively to lower blood pressure more than either drug alone. This combination can help reduce the risk of stroke and heart attack by maintaining healthy blood pressure levels. However, effectiveness can vary based on individual health conditions, and it's important to follow a healthcare provider's guidance when using these medications.
How effective is combination of Hydrochlorothiazide and Fosinopril?
Clinical studies have demonstrated the effectiveness of hydrochlorothiazide and fosinopril in lowering blood pressure and managing heart failure. Fosinopril, as an ACE inhibitor, has been shown to reduce blood pressure by decreasing vascular resistance. Hydrochlorothiazide, a diuretic, effectively reduces fluid retention and blood pressure by promoting the excretion of excess water and salt. When used together, these medications provide a synergistic effect, enhancing the overall antihypertensive and heart failure management benefits. The combination has been proven to be effective in various patient populations, regardless of age, race, or gender.
Directions for Use
What is the usual dose of combination of Fosinopril and Hydrochlorothiazide?
The usual dose of the combination of Fosinopril and Hydrochlorothiazide can vary based on individual health needs, but a common starting dose is often 10 mg of Fosinopril and 12.5 mg of Hydrochlorothiazide taken once daily. It's important to follow a healthcare provider's instructions, as they may adjust the dose based on how well the medication is working and any side effects. Fosinopril is an ACE inhibitor that helps relax blood vessels, while Hydrochlorothiazide is a diuretic that helps reduce excess fluid in the body.
What is the usual dose of combination of Hydrochlorothiazide and Fosinopril?
The usual adult daily dose for fosinopril, when used alone, ranges from 10 to 80 mg, depending on the patient's response and condition. For hydrochlorothiazide, the typical dose is 12.5 to 50 mg per day. When combined in a single tablet, the doses are often 10 mg of fosinopril with 12.5 mg of hydrochlorothiazide or 20 mg of fosinopril with 12.5 mg of hydrochlorothiazide. The combination is used to enhance the antihypertensive effect by utilizing both the ACE-inhibiting properties of fosinopril and the diuretic action of hydrochlorothiazide.
How does one take combination of Fosinopril and Hydrochlorothiazide?
Fosinopril and Hydrochlorothiazide are medications often combined to treat high blood pressure. Fosinopril is an ACE inhibitor, which helps relax blood vessels, while Hydrochlorothiazide is a diuretic, which helps the body get rid of excess salt and water. To take this combination: 1. **Follow the Prescription**: Always take the medication exactly as prescribed by your healthcare provider. Do not adjust the dose without consulting them. 2. **Timing**: It is usually taken once a day. Try to take it at the same time each day to maintain an even level in your bloodstream. 3. **With or Without Food**: You can take it with or without food, but taking it with food might help reduce stomach upset. 4. **Stay Hydrated**: Drink plenty of water unless your doctor advises otherwise, as Hydrochlorothiazide can increase urination. 5. **Monitor Blood Pressure**: Regularly check your blood pressure to ensure the medication is working effectively. 6. **Side Effects**: Be aware of potential side effects like dizziness, lightheadedness, or dehydration, and contact your doctor if these occur. For more detailed information, you can refer to trusted sources like the [NHS](https://www.nhs.uk/), [DailyMeds](https://dailymeds.co.uk/), or [NLM](https://www.nlm.nih.gov/).
How does one take combination of Hydrochlorothiazide and Fosinopril?
Hydrochlorothiazide and fosinopril can be taken with or without food, but it is important to take them at the same time each day to maintain consistent blood levels. Patients should follow any dietary recommendations provided by their healthcare provider, such as a low-salt or low-sodium diet, to enhance the effectiveness of the medication. It is also advised to avoid potassium supplements or salt substitutes containing potassium unless directed by a doctor, as these can interact with the medication.
For how long is combination of Fosinopril and Hydrochlorothiazide taken?
The combination of Fosinopril and Hydrochlorothiazide is typically taken as a long-term treatment for managing high blood pressure. The duration of treatment can vary depending on individual health needs and how well the medication is controlling blood pressure. It's important to follow your healthcare provider's instructions and have regular check-ups to determine the appropriate length of treatment. Always consult with your doctor before making any changes to your medication regimen.
For how long is combination of Hydrochlorothiazide and Fosinopril taken?
Hydrochlorothiazide and fosinopril are typically used as long-term treatments for managing high blood pressure and heart failure. These medications do not cure these conditions but help control them, so they are usually taken continuously, even if the patient feels well. Regular monitoring by a healthcare provider is essential to ensure the medications are working effectively and to adjust dosages as needed. Patients should not stop taking these medications without consulting their doctor.
How long does it take for combination of Fosinopril and Hydrochlorothiazide to work?
The combination of Fosinopril and Hydrochlorothiazide typically begins to work within a few hours after taking it. However, it may take several weeks to experience the full benefits in terms of blood pressure reduction. Fosinopril is an ACE inhibitor that helps relax blood vessels, while Hydrochlorothiazide is a diuretic that helps reduce excess fluid in the body. Together, they help lower blood pressure effectively.
How long does it take for combination of Hydrochlorothiazide and Fosinopril to work?
Fosinopril, an ACE inhibitor, typically begins to lower blood pressure within one hour of administration, with peak effects occurring between 2 to 6 hours. Hydrochlorothiazide, a diuretic, reaches peak plasma concentrations within 1 to 2.5 hours after oral administration. When combined, the effects of both medications contribute to a reduction in blood pressure, with the combination potentially enhancing the overall antihypertensive effect. The combination of these medications is designed to provide a more comprehensive approach to managing hypertension by addressing different mechanisms in the body.
Warnings and Precautions
Are there harms and risks from taking combination of Fosinopril and Hydrochlorothiazide?
Yes, there are potential harms and risks associated with taking a combination of Fosinopril and Hydrochlorothiazide. Fosinopril is a medication that helps lower blood pressure by relaxing blood vessels, while Hydrochlorothiazide is a diuretic that helps the body get rid of excess salt and water. Some common side effects of this combination can include dizziness, lightheadedness, or dehydration, especially when you first start taking it or if your dose is increased. This is because both medications can lower blood pressure, which might cause these symptoms. More serious risks can include kidney problems, as both medications can affect kidney function. It's important to have regular check-ups with your healthcare provider to monitor your kidney health. Additionally, there is a risk of an imbalance in electrolytes, such as low potassium levels, which can lead to muscle weakness or cramps. If you experience any severe side effects, such as difficulty breathing, swelling of the face or throat, or severe dizziness, you should seek medical attention immediately. Always discuss with your healthcare provider before starting or stopping any medication.
Are there harms and risks from taking combination of Hydrochlorothiazide and Fosinopril?
Common side effects of hydrochlorothiazide and fosinopril include dizziness, headache, and cough. Hydrochlorothiazide may cause frequent urination, diarrhea, and loss of appetite, while fosinopril can lead to upset stomach and vomiting. Significant adverse effects include swelling of the face or throat, difficulty breathing, and severe allergic reactions. Both medications can cause electrolyte imbalances, which may lead to symptoms like muscle cramps or weakness. Patients should report any severe or persistent side effects to their healthcare provider immediately.
Can I take combination of Fosinopril and Hydrochlorothiazide with other prescription drugs?
When taking a combination of Fosinopril and Hydrochlorothiazide, it's important to be cautious about interactions with other prescription drugs. Fosinopril is an ACE inhibitor, which helps relax blood vessels, and Hydrochlorothiazide is a diuretic, which helps remove excess fluid from the body. According to the NHS and NLM, these medications can interact with other drugs, potentially affecting how they work or increasing the risk of side effects. For example, combining them with other blood pressure medications can lead to excessively low blood pressure. Additionally, taking them with non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can reduce their effectiveness and increase the risk of kidney problems. It's crucial to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements, to ensure safe and effective treatment. Always follow your healthcare provider's advice on medication combinations.
Can I take combination of Hydrochlorothiazide and Fosinopril with other prescription drugs?
Significant prescription drug interactions with hydrochlorothiazide and fosinopril include those with other antihypertensive medications, which can enhance the blood pressure-lowering effects and increase the risk of hypotension. Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the effectiveness of both medications. Lithium levels can be increased, leading to toxicity, when taken with these drugs. Additionally, antacids can impair the absorption of fosinopril, and certain diuretics can increase the risk of electrolyte imbalances. Patients should inform their healthcare provider of all medications they are taking to manage these interactions effectively.
Can I take combination of Fosinopril and Hydrochlorothiazide if I am pregnant?
It is not recommended to take a combination of Fosinopril and Hydrochlorothiazide if you are pregnant. Fosinopril is an ACE inhibitor, which can harm the developing baby, especially in the second and third trimesters. Hydrochlorothiazide is a diuretic, which can also pose risks during pregnancy. It is important to consult with a healthcare professional for safer alternatives if you are pregnant or planning to become pregnant.
Can I take combination of Hydrochlorothiazide and Fosinopril if I am pregnant?
Hydrochlorothiazide and fosinopril are not recommended during pregnancy due to the risk of fetal toxicity. Fosinopril, an ACE inhibitor, can cause injury and death to the developing fetus, particularly in the second and third trimesters. Hydrochlorothiazide may lead to fetal or neonatal jaundice and other adverse effects. If pregnancy is detected, these medications should be discontinued as soon as possible, and alternative treatments should be considered to manage hypertension during pregnancy.
Can I take combination of Fosinopril and Hydrochlorothiazide while breastfeeding?
When considering the use of Fosinopril and Hydrochlorothiazide while breastfeeding, it's important to consult with a healthcare professional. According to the NHS, some medications can pass into breast milk and may affect the baby. Fosinopril is an ACE inhibitor, which can potentially affect the baby’s blood pressure and kidney function. Hydrochlorothiazide is a diuretic, which can reduce milk production. The NLM suggests that the combination of these drugs should be used with caution during breastfeeding, and only if the benefits to the mother outweigh the potential risks to the infant. Always discuss with your doctor to ensure the safety of both you and your baby.
Can I take combination of Hydrochlorothiazide and Fosinopril while breastfeeding?
Both hydrochlorothiazide and fosinopril are excreted in human milk, and there is potential for serious adverse reactions in nursing infants. Therefore, a decision should be made to either discontinue nursing or discontinue the medication, considering the importance of the drug to the mother. It is essential for breastfeeding mothers to discuss the risks and benefits with their healthcare provider to determine the best course of action for both mother and child.
Who should avoid taking combination of Fosinopril and Hydrochlorothiazide?
People who should avoid taking the combination of Fosinopril and Hydrochlorothiazide include those who are allergic to either of these medications or any of their ingredients. Additionally, individuals with severe kidney disease, liver disease, or those who have difficulty urinating should avoid this combination. Pregnant women should not take Fosinopril as it can harm the unborn baby. It's also important for people with a history of angioedema (swelling under the skin) related to previous ACE inhibitor use to avoid Fosinopril. Always consult a healthcare provider before starting or stopping any medication.
Who should avoid taking combination of Hydrochlorothiazide and Fosinopril?
Important warnings for hydrochlorothiazide and fosinopril include the risk of fetal toxicity, so they should not be used during pregnancy. Patients with a history of angioedema or hypersensitivity to ACE inhibitors or sulfonamide-derived drugs should avoid these medications. Caution is advised in patients with renal or hepatic impairment, as well as those with electrolyte imbalances. Both medications can cause significant drops in blood pressure, especially in volume-depleted individuals. Regular monitoring and communication with a healthcare provider are crucial to manage these risks effectively.
