Flutamide
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
Androgen Receptor Inhibitor
Controlled Drug Substance
No
Flutamide
Summary
Flutamide is primarily used to treat advanced prostate cancer. It is often prescribed in combination with other treatments to enhance its effectiveness.
Flutamide works by blocking the action of testosterone on cancer cells, which slows their growth. It is most effective when used with treatments that lower overall testosterone levels in the body.
The usual dose for adults is 250 mg three times daily, taken by mouth. It is usually taken with other treatments for prostate cancer. The dosage may vary based on the patient's condition and response to treatment.
Common side effects include nausea, diarrhea, hot flashes, breast tenderness, and fatigue. Serious risks include liver toxicity, breathing issues, and severe allergic reactions.
Flutamide should be avoided by people with severe liver disease, severe heart conditions, or a history of allergic reactions to it. Women, especially those who are pregnant or breastfeeding, should not take this medicine.
Indications and Purpose
How does Flutamide work?
Flutamide blocks androgen receptors, preventing testosterone from stimulating prostate cancer cells. By reducing testosterone activity, it slows cancer cell growth and prevents tumor progression. It is most effective when combined with LHRH agonists, which lower overall testosterone levels in the body.
Is Flutamide effective?
Yes, flutamide is effective in slowing prostate cancer growth, especially when used with LHRH agonists. Studies show it helps reduce tumor size, delay progression, and relieve symptoms. However, its effectiveness may decrease over time as cancer cells develop resistance. Regular monitoring is necessary to assess continued benefits.
What is Flutamide?
Flutamide is an anti-androgen medication used primarily to treat prostate cancer. It works by blocking the action of testosterone on cancer cells, slowing their growth. It is often prescribed alongside other treatments like luteinizing hormone-releasing hormone (LHRH) agonists to enhance its effectiveness. This helps manage advanced prostate cancer by reducing testosterone’s effect on tumor growth.
Directions for Use
For how long do I take Flutamide?
Flutamide is usually taken long-term as part of prostate cancer treatment. The duration depends on your doctor’s recommendation and cancer progression. In many cases, it is continued as long as it remains effective in slowing cancer growth. Your doctor may adjust or stop the medication based on your response and side effects.
How do I take Flutamide?
Flutamide should be taken by mouth with or without food. Taking it with food may help reduce stomach discomfort. The tablets should be swallowed whole with water. Avoid drinking alcohol while on this medication, as it may worsen side effects like liver toxicity. Always follow your doctor’s instructions carefully to ensure effectiveness.
How long does it take for Flutamide to start working?
Flutamide starts working within a few days by blocking testosterone, but noticeable benefits in cancer treatment may take weeks to months. Reduction in PSA levels (a prostate cancer marker) is often seen within a few weeks. Your doctor will monitor your progress through blood tests and symptoms to evaluate effectiveness.
How should I store Flutamide?
Store flutamide at room temperature (20-25°C), away from moisture and direct sunlight. Keep it in a tight container and out of reach of children. Do not store in the bathroom or near heat sources.
What is the usual dose of Flutamide?
The usual dose for adults is 250 mg three times daily (every 8 hours), totaling 750 mg per day. It is usually taken with LHRH agonists for prostate cancer. Dosage may vary based on the patient’s condition and response to treatment. Flutamide is not recommended for use in children due to lack of safety data.
Warnings and Precautions
Can Flutamide be taken safely while breastfeeding?
No, flutamide should not be used by breastfeeding women. It is not indicated for female patients, and its effects on breast milk are unknown. Women of childbearing age should avoid handling crushed or broken tablets due to potential risks.
Can Flutamide be taken safely while pregnant?
Flutamide is not safe during pregnancy. It can cause serious harm to the fetus and is strictly contraindicated in pregnant women. This medicine is only prescribed for male patients with prostate cancer.
Can I take Flutamide with other prescription drugs?
Flutamide can interact with blood thinners (warfarin), some seizure medications, and liver-affecting drugs. It may increase liver toxicity risks when combined with acetaminophen or alcohol. Your doctor will review your medication list to avoid harmful interactions.
Is Flutamide safe for the elderly?
Yes, flutamide is commonly prescribed to elderly men with prostate cancer. However, they are at a higher risk of liver toxicity and side effects like fatigue and hot flashes. Regular liver function tests and blood pressure monitoring are recommended.
Is it safe to drink alcohol while taking Flutamide?
Drinking alcohol while taking flutamide is not recommended, as it may increase the risk of liver toxicity and worsen side effects like nausea, dizziness, and fatigue. Alcohol can also put extra stress on the liver, which is already affected by flutamide. If you drink alcohol occasionally, consult your doctor to understand the risks and ensure safe use of the medication.
Is it safe to exercise while taking Flutamide?
Moderate exercise is generally safe while taking flutamide, but intense physical activity may cause fatigue or dizziness, which are common side effects of the medicine. If you feel weak or experience shortness of breath, adjust your exercise routine and stay hydrated. It’s important to listen to your body and avoid overexertion. Consulting your doctor before making major changes to your activity level is advisable.
Who should avoid taking Flutamide?
Flutamide should be avoided by people with severe liver disease, severe heart conditions, or a history of allergic reactions to it. Women, especially pregnant or breastfeeding women, should not take this medicine. People with severe kidney issues should use it with caution, and regular monitoring is required.
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