Fingolimod
Relapsing-Remitting Multiple Sclerosis
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Sphingosine 1-phosphate Receptor Modulator
Controlled Drug Substance
No
fingolimod
Summary
Fingolimod is used to treat relapsing forms of multiple sclerosis, which is a condition where the immune system attacks the protective covering of nerves. It helps reduce the frequency of relapses and slows the progression of physical disability.
Fingolimod works by modulating the sphingosine 1-phosphate receptor, which is involved in the movement of immune cells. It prevents certain immune cells from reaching the brain and spinal cord, reducing inflammation and nerve damage.
The usual starting dose of Fingolimod for adults is 0.5 mg taken once daily. It can be taken with or without food. Always follow your doctor's specific dosing instructions for your personal health needs.
Common side effects of Fingolimod include headache, flu-like symptoms, and back pain. These effects vary from person to person. If you notice new symptoms, talk with your doctor before stopping the medication.
Fingolimod can increase the risk of infections and may slow your heart rate, especially after the first dose. It should not be used by people with certain heart conditions or during pregnancy. Always consult your doctor about these concerns.
Indications and Purpose
How does Fingolimod work?
Fingolimod works by modulating the sphingosine 1-phosphate receptor, which is involved in the movement of immune cells. It prevents certain immune cells from leaving the lymph nodes, reducing their ability to reach the brain and spinal cord. This helps decrease inflammation and nerve damage in multiple sclerosis, leading to fewer relapses and slower progression of disability.
Is Fingolimod effective?
Fingolimod is effective in treating relapsing forms of multiple sclerosis, which is a condition where the immune system attacks the protective covering of nerves. Clinical studies show that Fingolimod can reduce the frequency of relapses and slow the progression of physical disability. It works by preventing certain immune cells from reaching the brain and spinal cord, which helps reduce inflammation and nerve damage.
What is Fingolimod?
Fingolimod is a medication used to treat relapsing forms of multiple sclerosis, which is a condition where the immune system attacks the protective covering of nerves. It belongs to a class of drugs called sphingosine 1-phosphate receptor modulators. Fingolimod works by preventing certain immune cells from reaching the brain and spinal cord, which helps reduce inflammation and nerve damage.
Directions for Use
For how long do I take Fingolimod?
Fingolimod is usually a long-term medication for managing relapsing forms of multiple sclerosis. You'll typically take Fingolimod every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your condition to worsen. Always talk with your doctor before changing or stopping your Fingolimod treatment.
How do I dispose of Fingolimod?
To dispose of Fingolimod, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Fingolimod?
Fingolimod is usually taken once daily. It's important to follow your doctor's instructions on how to take it. You can take it with or without food. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Always follow your doctor's specific advice about taking Fingolimod.
How long does it take for Fingolimod to start working?
Fingolimod begins working in your body shortly after you take it, but you may not notice all the benefits right away. It can take several weeks to see a reduction in the frequency of relapses and a slowing of disability progression. How quickly the medication works can depend on your overall health and how your body responds to the treatment. Take it exactly as prescribed for the best results.
How should I store Fingolimod?
Store Fingolimod at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Don't store it in humid places like bathrooms, where moisture could affect how well the medication works. Always store Fingolimod out of children's reach to prevent accidental swallowing.
What is the usual dose of Fingolimod?
The usual starting dose of Fingolimod for adults is 0.5 mg taken once daily. It's important to follow your doctor's specific dosing instructions. Your doctor may adjust your dose based on your response to the medication and any side effects you experience. Always follow your doctor's guidance for your personal health needs.
Warnings and Precautions
Can Fingolimod be taken safely while breastfeeding?
Fingolimod is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. However, it may pose risks to a breastfed infant. If you're taking Fingolimod and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Fingolimod be taken safely while pregnant?
Fingolimod is not recommended during pregnancy. Limited evidence suggests it may harm an unborn baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take Fingolimod with other prescription drugs?
Fingolimod can interact with certain medications, increasing the risk of adverse effects. For example, it can interact with drugs that affect heart rate, like beta-blockers, and increase the risk of slow heart rate. It can also interact with immunosuppressants, increasing the risk of infections. Always inform your doctor about all medications you're taking to avoid potential interactions.
Does Fingolimod have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Fingolimod include headache, flu-like symptoms, and back pain. Serious side effects can include infections, slow heart rate, and macular edema, which is swelling in the back of the eye. If you notice any new or worsening symptoms, contact your doctor immediately. They can help determine if these symptoms are related to Fingolimod.
Does Fingolimod have any safety warnings?
Yes, Fingolimod has important safety warnings. It can increase the risk of infections and may slow your heart rate, especially after the first dose. It can also cause macular edema, which is swelling in the back of the eye. Not adhering to these warnings can lead to serious health issues. Always follow your doctor's advice and report any unusual symptoms immediately.
Is Fingolimod addictive?
Fingolimod is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Fingolimod works by affecting your immune system to help manage multiple sclerosis. It doesn't affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that Fingolimod doesn't carry this risk.
Is Fingolimod safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Fingolimod, such as infections or heart-related issues. It's important for older adults to be closely monitored by their doctor while taking this medication. Regular check-ups can help manage any potential risks and ensure the treatment is safe and effective for elderly users.
Is it safe to drink alcohol while taking Fingolimod?
It's best to avoid alcohol while taking Fingolimod. Alcohol can increase the risk of side effects like dizziness or low blood pressure. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like dizziness or feeling faint. Talk with your doctor about alcohol use while taking Fingolimod to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Fingolimod?
You can exercise while taking Fingolimod, but keep a few things in mind. This medication can cause dizziness or fatigue, which might affect your exercise capacity. To exercise safely, drink plenty of water before, during, and after physical activity. Watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest. Check with your doctor if you have concerns about your specific situation.
Is it safe to stop Fingolimod?
Stopping Fingolimod suddenly can cause your multiple sclerosis symptoms to worsen. It's important to talk with your doctor before stopping the medication. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
What are the most common side effects of Fingolimod?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Fingolimod include headache, flu-like symptoms, and back pain. These effects vary from person to person. If you notice new symptoms after starting Fingolimod, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Fingolimod?
Fingolimod should not be used by people with certain heart conditions, such as recent heart attack or stroke, or those with severe untreated sleep apnea. These are absolute contraindications due to severe risks. Relative contraindications include liver problems or a history of uveitis, which is inflammation of the middle layer of the eye. Always consult your doctor about these concerns.
