Fexinidazole
African Trypanosomiasis
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
YES
Known Teratogen
No
Pharmaceutical Class
Nitroimidazole Antimicrobial
Controlled Drug Substance
No
Fexinidazole
Summary
Fexinidazole is used to treat a disease called human African trypanosomiasis, also known as sleeping sickness. It can treat both the early stage, where the disease is in the blood and lymph system, and the later stage, where it affects the brain and spinal cord.
Fexinidazole works by getting transformed into reactive substances in the body. These substances damage the DNA and proteins of the parasites causing sleeping sickness, leading to their death.
Fexinidazole is taken orally, once daily with food. For adults and children weighing 35 kg or more, the usual dose is 1800 mg for the first 4 days, followed by 1200 mg for the next 6 days. For children weighing 20 kg to less than 35 kg, the dose is 1200 mg for the first 4 days and 600 mg for the next 6 days.
Common side effects of Fexinidazole include headache, vomiting, insomnia, nausea, and weakness. More serious side effects can include changes in heart rhythm, mental health issues, and a decrease in white blood cells.
Fexinidazole should not be used by people who are allergic to similar drugs, have severe liver problems, or have a condition called Cockayne syndrome. It can cause a reaction if taken with alcohol, and it may not work as well in severe cases of sleeping sickness. It can also have effects on the heart and mental health, and can reduce white blood cells.
Indications and Purpose
How does Fexinidazole work?
Fexinidazole works by targeting the parasites that cause sleeping sickness. It interferes with the parasites' ability to function and reproduce, leading to their death. Think of it like cutting off the power supply to a machine, causing it to stop working. This action helps clear the infection from your body.
Is Fexinidazole effective?
Fexinidazole is effective in treating sleeping sickness, which is a parasitic disease transmitted by tsetse flies. Clinical studies show that Fexinidazole can cure the disease, especially in its early stages. It works by targeting the parasites in the body. The effectiveness of Fexinidazole makes it a valuable treatment option for this condition.
What is Fexinidazole?
Fexinidazole is a medication used to treat sleeping sickness, which is a parasitic disease transmitted by tsetse flies. It belongs to the nitroimidazole class of drugs and works by targeting the parasites in the body. Fexinidazole is taken orally and is effective in treating both early and late stages of the disease.
Directions for Use
For how long do I take Fexinidazole?
Fexinidazole is used for short-term treatment of acute infections like sleeping sickness. The usual duration is 10 days, with a specific dosing schedule. Always follow your doctor's instructions and complete the full course of treatment. Stopping the medication early can lead to incomplete treatment and potential relapse of the infection.
How do I dispose of Fexinidazole?
Dispose of unused Fexinidazole by taking it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away in the trash.
How do I take Fexinidazole?
Take Fexinidazole as directed by your doctor. It's usually taken once daily with food to help with absorption. Do not crush or chew the tablets. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Avoid taking two doses at once. Follow any dietary or beverage restrictions your doctor advises.
How long does it take for Fexinidazole to start working?
Fexinidazole starts working soon after you take it, but the full therapeutic effect may take several days. The time it takes to see improvement can vary based on the severity of the infection and individual factors. It's important to complete the full course of treatment as prescribed by your doctor to ensure the infection is fully treated.
How should I store Fexinidazole?
Store Fexinidazole tablets at room temperature, away from moisture and light. Keep them in a tightly closed container. Avoid storing the medication in humid places like bathrooms. Always keep Fexinidazole out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Fexinidazole?
The usual dose of Fexinidazole for adults is 1800 mg once daily for the first four days, followed by 1200 mg once daily for the next six days. This dosing schedule is typically used for treating sleeping sickness. Always follow your doctor's specific dosing instructions for your health needs. Dose adjustments may be necessary for special populations, such as children or the elderly.
Warnings and Precautions
Can Fexinidazole be taken safely while breastfeeding?
Fexinidazole is not recommended while breastfeeding. There is limited information on whether it passes into human breast milk, but it may pose risks to the baby. If you're taking Fexinidazole and want to breastfeed, discuss safer medication options with your doctor to ensure your baby's safety.
Can Fexinidazole be taken safely while pregnant?
Fexinidazole is not recommended during pregnancy due to potential risks to the unborn baby. There is limited evidence on its safety during pregnancy, and animal studies suggest possible harm. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for your condition.
Can I take Fexinidazole with other prescription drugs?
Fexinidazole may interact with other medications, increasing the risk of side effects or reducing effectiveness. It's important to inform your doctor about all the medicines you take, including prescription, over-the-counter, and herbal products. Your doctor can help manage potential interactions and adjust your treatment plan as needed.
Does Fexinidazole have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Fexinidazole include nausea, vomiting, and headache. These effects are usually mild. Serious adverse effects, like liver problems or allergic reactions, are rare but require immediate medical attention. If you notice any new or worsening symptoms while taking Fexinidazole, contact your doctor promptly.
Does Fexinidazole have any safety warnings?
Fexinidazole has important safety warnings. It can cause side effects like nausea, vomiting, and headache. Serious side effects include liver problems and allergic reactions. Not following safety warnings can lead to severe health issues. Always take Fexinidazole as prescribed and report any unusual symptoms to your doctor immediately. Regular monitoring by your healthcare provider is essential to ensure safe use.
Is Fexinidazole addictive?
Fexinidazole is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Fexinidazole works by targeting parasites in the body and doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Fexinidazole safe for the elderly?
Elderly individuals may be more vulnerable to the side effects of Fexinidazole, such as dizziness or liver problems. It's important for older adults to be closely monitored by their healthcare provider while taking this medication. Regular check-ups can help ensure safe use and adjust the treatment if necessary.
Is it safe to drink alcohol while taking Fexinidazole?
It's best to avoid alcohol while taking Fexinidazole. Alcohol can increase the risk of side effects like nausea and dizziness. It may also interfere with the effectiveness of the medication. If you choose to drink occasionally, limit your alcohol intake and watch for any unusual symptoms. Talk with your doctor about alcohol use while taking Fexinidazole.
Is it safe to exercise while taking Fexinidazole?
You can exercise while taking Fexinidazole, but be cautious. This medication can cause dizziness or fatigue, which might affect your exercise capacity. To exercise safely, stay hydrated and avoid strenuous activities if you feel unwell. If you notice any unusual symptoms during physical activity, slow down or stop and rest. Consult your doctor if you have concerns about exercising while on Fexinidazole.
Is it safe to stop Fexinidazole?
Fexinidazole is usually taken for a short-term treatment of acute infections like sleeping sickness. Stopping the medication before completing the prescribed course can lead to incomplete treatment and potential relapse of the infection. Always follow your doctor's instructions and complete the full course of treatment. If you have concerns about stopping Fexinidazole, discuss them with your healthcare provider.
What are the most common side effects of Fexinidazole?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Fexinidazole include nausea, vomiting, and headache. These effects are usually mild and temporary. If you notice new symptoms after starting Fexinidazole, they might be unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Fexinidazole?
Fexinidazole should not be used if you are allergic to it or its ingredients. Serious allergic reactions require immediate medical help. This medication is not recommended for people with severe liver problems. Pregnant or breastfeeding women should avoid Fexinidazole due to potential risks to the baby. Always consult your doctor about any concerns before starting Fexinidazole.
