Exemestane
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Aromatase Inhibitor
Controlled Drug Substance
No
Exemestane
Summary
Exemestane is used to treat hormone-receptor-positive breast cancer, which is a type of cancer that grows in response to estrogen, in postmenopausal women. It is often prescribed after initial treatment with tamoxifen, another breast cancer medication, to reduce the risk of cancer coming back.
Exemestane works by blocking aromatase, which is an enzyme that converts androgens into estrogen. By lowering estrogen levels, it helps slow or stop the growth of breast cancer cells that need estrogen to grow, similar to turning off a water supply to a plant.
The usual dose of Exemestane for adults is 25 mg taken once daily after a meal. It is typically taken as a tablet that should be swallowed whole, not crushed or chewed. This dose is usually maintained throughout the treatment unless your doctor advises otherwise.
Common side effects of Exemestane include hot flashes, which are sudden feelings of warmth, and joint pain. Some people may also experience fatigue, which is feeling unusually tired. These side effects are generally mild to moderate and occur in more than 10% of users.
Exemestane can cause bone loss, leading to osteoporosis, which is a condition where bones become weak. It may also cause liver problems, so liver function should be monitored. It is not safe for pregnant women, as it can harm the fetus, and should not be used by those allergic to it.
Indications and Purpose
How does Exemestane work?
Exemestane works by blocking the enzyme aromatase, which is responsible for converting androgens into estrogen in the body. By reducing estrogen levels, Exemestane helps slow or stop the growth of hormone-receptor-positive breast cancer cells that rely on estrogen to grow. Think of it like turning off a water supply to a plant, causing it to wither. This mechanism makes Exemestane effective in treating certain types of breast cancer, particularly in postmenopausal women.
Is Exemestane effective?
Exemestane is effective in treating certain types of breast cancer. It works by lowering estrogen levels, which can slow or stop the growth of cancer cells that need estrogen to grow. Clinical studies show that Exemestane significantly reduces the risk of cancer recurrence in postmenopausal women with hormone-receptor-positive breast cancer. It is often used after initial treatment with tamoxifen, another breast cancer medication. Exemestane is a valuable part of breast cancer treatment, helping to improve long-term outcomes.
What is Exemestane?
Exemestane is a medication used to treat certain types of breast cancer. It belongs to a class of drugs called aromatase inhibitors, which work by lowering estrogen levels in the body. Estrogen can promote the growth of some breast cancers, so reducing its levels can help slow or stop cancer growth. Exemestane is primarily used in postmenopausal women with hormone-receptor-positive breast cancer. It is often used after initial treatment with tamoxifen, another breast cancer medication, to reduce the risk of cancer recurrence.
Directions for Use
For how long do I take Exemestane?
Exemestane is usually taken long-term for breast cancer treatment. The duration depends on your specific condition and response to the medication. It's often used for several years to reduce the risk of cancer recurrence. Your doctor will determine the appropriate length of treatment based on your individual needs. Always follow your doctor's instructions and discuss any concerns about the duration of your treatment. Do not stop taking Exemestane without consulting your healthcare provider.
How do I dispose of Exemestane?
To dispose of Exemestane, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If a take-back program is not available, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Exemestane?
Take Exemestane once daily after a meal, usually in the morning. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember, unless it's close to your next dose. In that case, skip the missed dose. Do not double up on doses. There are no specific dietary restrictions, but follow your doctor's advice. Avoid alcohol, as it may increase side effects. Always follow your doctor's instructions for the best results.
How long does it take for Exemestane to start working?
Exemestane starts working in your body shortly after you take it, but the full therapeutic effects may take several weeks to become noticeable. The time it takes to see results can vary depending on individual factors like your overall health and the specific condition being treated. Regular check-ups and monitoring by your doctor will help assess the effectiveness of the treatment. Always take Exemestane as prescribed and discuss any concerns about its effectiveness with your healthcare provider.
How should I store Exemestane?
Store Exemestane at room temperature, away from moisture and light. Keep it in its original container, tightly closed. Do not store it in the bathroom, where humidity can affect the medication. Exemestane does not require refrigeration. Always keep it out of reach of children and pets. Check the expiration date regularly and properly dispose of any unused or expired medication. If you have questions about storage, consult your pharmacist or healthcare provider for guidance.
What is the usual dose of Exemestane?
The usual starting dose of Exemestane for adults is 25 mg once daily after a meal. This dose is typically maintained throughout treatment. Dose adjustments are not commonly needed, but your doctor may make changes based on your response or side effects. Exemestane is not typically used in children. Elderly patients usually follow the same dosing as adults, but they should be monitored closely for side effects. Always follow your doctor's specific dosing instructions.
Warnings and Precautions
Can Exemestane be taken safely while breastfeeding?
Exemestane is not recommended while breastfeeding. There is limited information on whether it passes into breast milk, but it could potentially affect the breastfed infant. The medication might interfere with milk production. If you are taking Exemestane and wish to breastfeed, discuss safer medication options with your doctor. They can help you find a treatment plan that allows you to nurse your baby safely while managing your health condition.
Can Exemestane be taken safely while pregnant?
Exemestane is not safe to use during pregnancy. It can harm the developing fetus, leading to birth defects or pregnancy loss. There is limited evidence on the safety of most medicines during pregnancy, but Exemestane is contraindicated for pregnant women. If you are pregnant or planning to become pregnant, talk with your doctor about safer alternatives. Your doctor can help create a treatment plan that protects both you and your baby during this important time.
Can I take Exemestane with other prescription drugs?
Exemestane can interact with certain medications, which may increase the risk of side effects or reduce its effectiveness. For example, drugs like rifampin, which is an antibiotic, can decrease Exemestane's effectiveness. Always inform your doctor about all medications you are taking, including over-the-counter drugs and supplements. They can help you avoid potential interactions and ensure your treatment is safe and effective. Regular monitoring and communication with your healthcare provider are key to managing your health while on Exemestane.
Does Exemestane have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Exemestane include hot flashes, which are sudden feelings of warmth, and joint pain. These occur in more than 10% of users. Serious adverse effects, like liver problems or bone loss, are less common but require immediate medical attention. If you notice any new or worsening symptoms, contact your doctor. They can help determine if these are related to Exemestane and suggest appropriate management.
Does Exemestane have any safety warnings?
Yes, Exemestane has important safety warnings. It can cause bone loss, which may lead to osteoporosis, a condition where bones become weak and brittle. Regular bone density tests are recommended. Exemestane may also cause liver problems, so liver function should be monitored. If you experience symptoms like jaundice, which is yellowing of the skin or eyes, seek medical attention. Not adhering to these warnings can lead to serious health issues. Always follow your doctor's advice and report any unusual symptoms.
Is Exemestane addictive?
Exemestane is not addictive or habit-forming. It does not cause physical or psychological dependence. This medication works by blocking the production of estrogen, which is a hormone that can promote the growth of certain types of breast cancer. Since it does not affect brain chemistry, there is no risk of addiction. You won't experience cravings or withdrawal symptoms when stopping Exemestane. Always follow your doctor's instructions when taking or discontinuing this medication.
Is Exemestane safe for the elderly?
Exemestane is generally safe for elderly patients, but they may be more vulnerable to certain side effects. Older adults are at higher risk for bone loss, which can lead to osteoporosis, a condition where bones become weak and brittle. Regular bone density tests are recommended. Elderly patients should also be monitored for liver function, as they may be more susceptible to liver problems. Always follow your doctor's advice and report any unusual symptoms while taking Exemestane.
Is it safe to drink alcohol while taking Exemestane?
It's best to avoid alcohol while taking Exemestane. Alcohol can increase the risk of side effects like dizziness or liver problems. It may also interfere with the effectiveness of the medication. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like nausea or dizziness. These symptoms could indicate a problem and require medical attention. Talk with your doctor about alcohol use while taking Exemestane for personalized advice.
Is it safe to exercise while taking Exemestane?
You can exercise while taking Exemestane, but be mindful of your body's response. This medication can cause joint pain or fatigue, which might affect your exercise capacity. If you experience these symptoms, consider low-impact activities like walking or swimming. Stay hydrated and listen to your body. If you feel dizzy or unusually tired, slow down or stop exercising and rest. Consult your doctor if you have concerns about your exercise routine while on Exemestane.
Is it safe to stop Exemestane?
It's important not to stop Exemestane without consulting your doctor. This medication is usually taken long-term for breast cancer treatment. Stopping it suddenly can increase the risk of cancer recurrence. There are no withdrawal symptoms, but the benefits of the medication will stop. Your doctor may suggest a gradual reduction or an alternative treatment if needed. Always discuss any concerns with your healthcare provider before making changes to your medication regimen.
What are the most common side effects of Exemestane?
Side effects are unwanted reactions to a medication. Common side effects of Exemestane include hot flashes, which are sudden feelings of warmth, and joint pain. These occur in more than 10% of users. Some people may also experience fatigue, which is feeling unusually tired. These side effects are generally mild to moderate. If you notice new symptoms after starting Exemestane, they might be temporary or unrelated. Talk with your doctor before stopping any medication.
Who should avoid taking Exemestane?
Exemestane should not be used if you are allergic to it or any of its ingredients. This is an absolute contraindication. Serious allergic reactions, which cause rash, hives, or difficulty breathing, require immediate medical help. Exemestane is not for premenopausal women or pregnant women, as it can harm the fetus. These are also absolute contraindications. Use caution if you have liver or kidney problems, as these are relative contraindications. Always consult your doctor about these concerns.
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