Everolimus
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
Definite
Pharmaceutical Class
Kinase Inhibitor and MTOR Inhibitor Immunosuppressant
Controlled Drug Substance
No
Everolimus
Summary
Everolimus is used to treat certain types of cancer, such as kidney and breast cancer, and to prevent organ rejection after a transplant. It helps slow cancer cell growth and suppresses the immune system to prevent rejection.
Everolimus works by inhibiting a protein called mTOR, which is involved in cell growth and division. This action slows down cancer cell growth and suppresses the immune system to prevent organ rejection.
The usual starting dose for adults is 10 mg once daily, with a maximum of 20 mg daily. It is taken orally, with or without food, but consistently. Dose adjustments may be needed based on response and side effects.
Common side effects include mouth sores, infections, and fatigue. These effects vary among individuals and should be discussed with a doctor if they occur.
Everolimus should not be used if allergic to it or its ingredients. It is contraindicated in severe liver problems and requires caution with infections or lung issues. Always inform your doctor about your medical history.
Indications and Purpose
How does Everolimus work?
Everolimus works by inhibiting a protein called mTOR, which is involved in cell growth and division. Think of it like a traffic light that controls cell growth signals. By blocking mTOR, Everolimus slows down the growth of cancer cells and suppresses the immune system to prevent organ rejection. This helps manage cancer progression and supports organ transplant success. Your doctor will monitor your response to ensure the medication is working effectively.
Is Everolimus effective?
Yes, Everolimus is effective for its approved uses. It is primarily used to treat certain types of cancer and prevent organ rejection after a transplant. Clinical studies show that Everolimus can improve health outcomes in these conditions. It works by inhibiting a protein that helps cancer cells grow and by suppressing the immune system to prevent organ rejection. Your doctor will monitor your condition to ensure Everolimus is working effectively for you.
What is Everolimus?
Everolimus is a medication that belongs to a class called mTOR inhibitors, which work by blocking a protein that helps cells grow. It's primarily used to treat certain types of cancer and to prevent organ rejection after a transplant. By inhibiting cell growth, Everolimus helps slow the progression of cancer and suppresses the immune system to prevent the body from rejecting a transplanted organ. It is often used in combination with other therapies.
Directions for Use
For how long do I take Everolimus?
Everolimus is usually taken long-term for chronic conditions like cancer or to prevent organ rejection. The duration depends on your condition and how your body responds. Your doctor will guide you on how long to take Everolimus. Regular check-ups are important to monitor your progress and adjust your treatment as needed. Always talk with your doctor before changing or stopping your medication.
How do I dispose of Everolimus?
Dispose of Everolimus by taking it to a drug take-back program or collection site at a pharmacy or hospital. If these options aren't available, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away. This helps prevent accidental ingestion or harm to the environment.
How do I take Everolimus?
Take Everolimus once daily, at the same time each day, either in the morning or evening. Swallow the tablet whole with a glass of water; do not crush or chew it. You can take it with or without food, but be consistent with your choice. Avoid grapefruit and grapefruit juice, as they can interfere with the medicine. If you miss a dose, take it as soon as you remember unless it's close to your next dose. Do not double up on doses.
How long does it take for Everolimus to start working?
Everolimus starts working in your body shortly after you take it, but the full therapeutic effects may take weeks to months to appear. The time it takes to work can depend on your condition and overall health. For cancer, it may take several weeks to see changes. For organ transplant patients, it helps prevent rejection soon after starting. Regular monitoring by your doctor will help assess its effectiveness.
How should I store Everolimus?
Store Everolimus at room temperature, away from moisture and light. Keep it in its original container, tightly closed. Do not store it in humid places like bathrooms. If the packaging isn't child-resistant, transfer it to a container that children can't open. Always keep Everolimus out of children's reach to prevent accidental ingestion. Check the expiration date regularly and dispose of any unused or expired medication properly.
What is the usual dose of Everolimus?
The usual starting dose of Everolimus for adults is 10 mg once daily. Your doctor may adjust the dose based on your response and any side effects. The maximum recommended dose is 20 mg daily. For children or the elderly, dose adjustments may be necessary. Always follow your doctor's specific dosing instructions for your health needs. They will monitor your condition and make any necessary changes to your treatment.
Warnings and Precautions
Can Everolimus be taken safely while breastfeeding?
Everolimus is not recommended while breastfeeding. There is limited information on whether it passes into breast milk, but it may pose risks to a nursing infant. The effects on milk supply are also unknown. If you're breastfeeding or planning to breastfeed, discuss with your doctor. They can help you consider the risks and benefits and explore safer alternatives for your treatment.
Can Everolimus be taken safely while pregnant?
Everolimus is not recommended during pregnancy. There is limited evidence on its safety, and it may harm an unborn baby. Animal studies have shown potential risks, but human data is lacking. If you're pregnant or planning to become pregnant, talk with your doctor. They can help you weigh the risks and benefits and explore safer treatment options during pregnancy.
Can I take Everolimus with other prescription drugs?
Everolimus has several drug interactions. It should not be taken with strong CYP3A4 inhibitors like ketoconazole, which can increase Everolimus levels and side effects. CYP3A4 inducers like rifampin can decrease its effectiveness. Always inform your doctor about all medications you take. They can help manage interactions and adjust your treatment to ensure safety and effectiveness.
Does Everolimus have adverse effects?
Yes, Everolimus can have adverse effects, which are unwanted reactions to a medication. Common adverse effects include mouth sores, infections, and fatigue. Serious side effects can include lung or kidney problems and increased risk of infections. If you notice any new or worsening symptoms, contact your doctor immediately. They can help determine if these are related to Everolimus and adjust your treatment as needed to ensure your safety.
Does Everolimus have any safety warnings?
Yes, Everolimus has important safety warnings. It can increase the risk of infections and may cause lung or kidney problems. It can also affect blood cell counts and increase the risk of bleeding. Not following these warnings can lead to serious health issues. Always adhere to your doctor's advice and report any unusual symptoms immediately. Regular monitoring and check-ups are crucial to ensure your safety while taking Everolimus.
Is Everolimus addictive?
No, Everolimus is not addictive. It does not have habit-forming potential and does not cause dependency or withdrawal symptoms. Everolimus works by affecting certain pathways in the body, not brain chemistry, so it doesn't lead to addiction. You won't experience cravings or feel compelled to take more than prescribed. If you have concerns about medication dependence, rest assured that Everolimus doesn't carry this risk.
Is Everolimus safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Everolimus, such as infections or kidney problems. They may also have other health conditions that require careful monitoring. Everolimus can be used safely in the elderly with proper medical supervision. Regular check-ups and communication with your doctor are important to manage any risks and ensure the medication is effective.
Is it safe to drink alcohol while taking Everolimus?
It's best to avoid alcohol while taking Everolimus. Alcohol can increase the risk of liver damage and may worsen side effects like dizziness or nausea. If you choose to drink, do so in moderation and watch for any warning signs. Talk with your doctor about alcohol use while on Everolimus to get personalized advice based on your health situation.
Is it safe to exercise while taking Everolimus?
Yes, you can exercise while taking Everolimus, but be cautious. This medication can cause fatigue or dizziness, which might affect your exercise capacity. Listen to your body and avoid strenuous activities if you feel unwell. Stay hydrated and take breaks as needed. If you experience unusual symptoms during exercise, stop and rest. Consult your doctor if you have concerns about exercising while on Everolimus.
Is it safe to stop Everolimus?
No, it's not safe to stop Everolimus suddenly without consulting your doctor. Everolimus is usually used long-term for chronic conditions. Stopping it abruptly can worsen your condition or cause withdrawal symptoms. Always talk with your doctor before making any changes to your medication. They can guide you on how to safely stop or adjust your treatment to protect your health.
What are the most common side effects of Everolimus?
Common side effects of Everolimus include mouth sores, infections, and fatigue. These side effects vary from person to person. If you experience new symptoms after starting Everolimus, they might be temporary or unrelated to the medication. It's important to talk with your doctor before stopping any medication. They can help determine if the side effects are related to Everolimus and suggest ways to manage them.
Who should avoid taking Everolimus?
Everolimus should not be used if you are allergic to it or its ingredients. It is contraindicated in patients with severe liver problems. Caution is needed if you have a history of infections or lung problems. Always inform your doctor about your medical history before starting Everolimus. They will assess the risks and benefits to determine if Everolimus is safe for you.
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