Ertugliflozin + Sitagliptin
Find more information about this combination medication at the webpages for ertugliflozin and sitagliptin
Type 2 Diabetes Mellitus
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Advisory
- This medicine contains a combination of 2 drugs ertugliflozin and sitagliptin.
- ertugliflozin and sitagliptin are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Dipeptidyl Peptidase 4 Inhibitor
Controlled Drug Substance
NO
Summary
Ertugliflozin and sitagliptin are used to manage type 2 diabetes, which is a condition where the body doesn't use insulin properly, leading to high blood sugar levels. They are prescribed when diet and exercise alone are not enough to control blood sugar. These medications help lower blood sugar levels, reducing the risk of diabetes-related complications.
Ertugliflozin, an SGLT2 inhibitor, helps the kidneys remove excess glucose from the blood through urine. Sitagliptin, a DPP-4 inhibitor, increases insulin production and decreases sugar production in the liver. Together, they provide a dual approach to lowering blood sugar levels, making them effective in managing diabetes when used in combination.
Ertugliflozin is typically taken as a 5 mg to 15 mg tablet once daily, depending on individual needs. Sitagliptin is usually prescribed as a 100 mg tablet once daily. Both medications are taken orally, with or without food, making them convenient for daily use. It's important to follow the healthcare provider's instructions regarding dosage and timing.
Common side effects of ertugliflozin include urinary tract infections and increased urination, due to its action on the kidneys. Sitagliptin may cause headaches and upper respiratory infections. Both medicines can lead to low blood sugar, especially when combined with other diabetes medications. Monitoring by a healthcare provider is important to manage these risks.
Ertugliflozin should not be used in people with severe kidney problems or those on dialysis, as it can worsen kidney function. Sitagliptin should be used cautiously in people with a history of pancreatitis, which is inflammation of the pancreas. Both medications can cause low blood sugar, especially when combined with other diabetes drugs. Regular monitoring is essential.
Indications and Purpose
How does combination of ertugliflozin and sitagliptin work?
Ertugliflozin and sitagliptin work together to control blood sugar levels in people with type 2 diabetes. Ertugliflozin, which is an SGLT2 inhibitor, helps the kidneys remove excess glucose from the blood through urine. Sitagliptin, which is a DPP-4 inhibitor, increases insulin production and decreases sugar production in the liver. Together, they provide a dual approach to lowering blood sugar levels, making them effective in managing diabetes when used in combination.
How does combination of Ertugliflozin and Sitagliptin work?
Ertugliflozin works by inhibiting the sodium-glucose co-transporter 2 (SGLT2) in the kidneys, which reduces glucose reabsorption and increases glucose excretion in urine. Sitagliptin, on the other hand, inhibits the enzyme dipeptidyl peptidase-4 (DPP-4), which increases levels of incretin hormones, enhancing insulin release and reducing glucagon levels. Together, they provide a dual mechanism to lower blood sugar levels in type 2 diabetes, with Ertugliflozin focusing on renal glucose excretion and Sitagliptin enhancing pancreatic insulin response.
How effective is combination of ertugliflozin and sitagliptin?
Clinical studies have shown that both ertugliflozin and sitagliptin effectively lower blood sugar levels in people with type 2 diabetes. Ertugliflozin works by helping the kidneys remove excess glucose, while sitagliptin increases insulin levels and reduces sugar production in the liver. When used together, they provide a complementary effect, leading to significant reductions in HbA1c levels. The combination has been proven to be more effective than using either medicine alone, offering a comprehensive approach to managing blood sugar levels.
How effective is combination of Ertugliflozin and Sitagliptin?
Clinical trials have demonstrated that the combination of Ertugliflozin and Sitagliptin effectively lowers HbA1c levels in adults with type 2 diabetes. Ertugliflozin has been shown to increase glucose excretion through urine, while Sitagliptin enhances insulin release and reduces glucagon levels. Together, they provide a complementary approach to improving glycemic control. Studies have also indicated that this combination can help reduce the risk of diabetes-related complications, such as cardiovascular issues and kidney problems, by maintaining better blood sugar levels.
Directions for Use
What is the usual dose of combination of ertugliflozin and sitagliptin?
The usual adult daily dose for ertugliflozin is typically 5 mg to 15 mg once daily, depending on the individual's needs and response to treatment. Sitagliptin is usually prescribed at a dose of 100 mg once daily. These doses may be adjusted by a healthcare provider based on blood sugar levels and other factors. It's important to follow the prescribed dosage and consult a healthcare provider for any adjustments needed.
What is the usual dose of combination of Ertugliflozin and Sitagliptin?
The usual adult daily dose for the combination of Ertugliflozin and Sitagliptin is typically 5 mg of Ertugliflozin and 100 mg of Sitagliptin taken orally once a day. This combination can be adjusted based on the patient's response and tolerance, with Ertugliflozin potentially increased to 15 mg while maintaining Sitagliptin at 100 mg. Both medications are taken together to enhance blood sugar control in adults with type 2 diabetes, complementing each other's mechanisms of action.
How does one take combination of ertugliflozin and sitagliptin?
Ertugliflozin and sitagliptin can be taken with or without food, making them convenient for daily use. There are no specific food restrictions, but maintaining a balanced diet is important for managing diabetes. It's crucial to follow the healthcare provider's instructions regarding dosage and timing. Regular monitoring of blood sugar levels is recommended to ensure the medications are working effectively. Always consult a healthcare provider for personalized advice and guidance.
How does one take combination of Ertugliflozin and Sitagliptin?
Ertugliflozin and Sitagliptin can be taken with or without food, usually once daily in the morning. It's important to take the medication at the same time each day to maintain consistent blood levels. Patients should follow their healthcare provider's dietary recommendations, which typically include a balanced diet to help manage diabetes. There are no specific food restrictions, but maintaining adequate hydration is important, especially with Ertugliflozin, to prevent dehydration.
For how long is combination of ertugliflozin and sitagliptin taken?
Ertugliflozin and sitagliptin are typically used as long-term treatments for managing type 2 diabetes. The duration of use depends on individual response and blood sugar control. These medications are often part of a comprehensive diabetes management plan, which includes diet and exercise. Regular follow-ups with a healthcare provider are important to assess effectiveness and make any necessary adjustments to the treatment plan. It's essential to continue taking the medications as prescribed to maintain blood sugar control.
For how long is combination of Ertugliflozin and Sitagliptin taken?
Ertugliflozin and Sitagliptin are typically used as long-term treatments for managing type 2 diabetes. They are intended to be taken daily, alongside lifestyle changes such as diet and exercise, to maintain blood sugar control over time. The duration of use is generally indefinite, as diabetes is a chronic condition requiring ongoing management. Patients should continue taking these medications as prescribed, even if they feel well, and should not stop without consulting their healthcare provider.
How long does it take for combination of ertugliflozin and sitagliptin to work?
Ertugliflozin and sitagliptin, when combined, start working relatively quickly to help control blood sugar levels. Ertugliflozin, which is a type of medicine called an SGLT2 inhibitor, works by helping the kidneys remove glucose from the bloodstream. Sitagliptin, which is a DPP-4 inhibitor, helps increase the levels of insulin after meals and decreases the amount of sugar made by the body. Together, they help lower blood sugar levels, and you may start to see effects within a few days, although it might take a few weeks to see the full benefits.
How long does it take for combination of Ertugliflozin and Sitagliptin to work?
Ertugliflozin and Sitagliptin work together to lower blood sugar levels in adults with type 2 diabetes. Ertugliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, starts working by increasing glucose excretion through urine, while Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, enhances insulin release and decreases glucagon levels. Both medications typically begin to show effects within a few days of starting treatment, but it may take several weeks to see the full benefits in blood sugar control. The combination aims to improve glycemic control more effectively than either drug alone.
Warnings and Precautions
Are there harms and risks from taking combination of ertugliflozin and sitagliptin?
Common side effects of ertugliflozin include urinary tract infections and increased urination, due to its action on the kidneys. Sitagliptin may cause side effects like headaches and upper respiratory infections. Both medicines can lead to low blood sugar, especially when combined with other diabetes medications. Significant adverse effects include the risk of pancreatitis, which is inflammation of the pancreas, with sitagliptin, and dehydration or kidney problems with ertugliflozin. Monitoring by a healthcare provider is important to manage these risks.
Are there harms and risks from taking combination of Ertugliflozin and Sitagliptin?
Common side effects of Ertugliflozin include increased urination, thirst, and genital yeast infections. Sitagliptin may cause upper respiratory infections, headache, and diarrhea. Significant adverse effects for both include the risk of pancreatitis and severe allergic reactions. Ertugliflozin can also lead to dehydration and an increased risk of lower limb amputation, while Sitagliptin may cause joint pain and skin reactions. Patients should be aware of these potential side effects and consult their healthcare provider if they experience any severe or persistent symptoms.
Can I take combination of ertugliflozin and sitagliptin with other prescription drugs?
Ertugliflozin and sitagliptin can interact with other prescription drugs that affect blood sugar levels, such as insulin or sulfonylureas, increasing the risk of hypoglycemia, which is low blood sugar. Sitagliptin may interact with drugs that affect liver enzymes, potentially altering its effectiveness. It's important to inform healthcare providers about all medications being taken to avoid interactions. Regular monitoring of blood sugar levels and possible dosage adjustments can help manage these interactions effectively.
Can I take combination of Ertugliflozin and Sitagliptin with other prescription drugs?
Ertugliflozin and Sitagliptin can interact with other diabetes medications, such as insulin or sulfonylureas, increasing the risk of hypoglycemia. Ertugliflozin may also interact with diuretics, potentially leading to dehydration or low blood pressure. Sitagliptin can interact with medications that affect the kidneys, as it is primarily excreted through the renal system. Patients should inform their healthcare provider of all medications they are taking to manage potential interactions effectively.
Can I take combination of ertugliflozin and sitagliptin if I am pregnant?
The safety of ertugliflozin and sitagliptin during pregnancy is not well established. Ertugliflozin is generally not recommended during the second and third trimesters due to potential risks to the developing baby. Sitagliptin's effects during pregnancy are also not fully understood, and it should be used only if the potential benefits justify the risks. Pregnant women should discuss with their healthcare provider to weigh the risks and benefits and consider alternative treatments for managing blood sugar during pregnancy.
Can I take combination of Ertugliflozin and Sitagliptin if I am pregnant?
Ertugliflozin and Sitagliptin are not recommended during pregnancy due to potential risks to the developing fetus. Animal studies have shown adverse renal effects with Ertugliflozin, and there is limited data on the use of Sitagliptin in pregnant women. Poorly controlled diabetes during pregnancy can lead to complications, so alternative treatments may be considered. Women who are pregnant or planning to become pregnant should discuss their treatment options with their healthcare provider to ensure the best outcomes for both mother and child.
Can I take combination of ertugliflozin and sitagliptin while breastfeeding?
The safety of ertugliflozin and sitagliptin during breastfeeding is not well established. Ertugliflozin is not recommended for breastfeeding mothers due to the potential risk to the infant, as it may pass into breast milk. The effects of sitagliptin on a breastfeeding infant are also not fully known, so caution is advised. Mothers should consult their healthcare provider to discuss the risks and benefits and explore alternative options for managing diabetes while breastfeeding.
Can I take combination of Ertugliflozin and Sitagliptin while breastfeeding?
The safety of Ertugliflozin and Sitagliptin during lactation and breastfeeding is not well established. Ertugliflozin is present in the milk of lactating rats, and there may be a risk to the developing human kidney if exposed during breastfeeding. Sitagliptin is also secreted in the milk of lactating rats. Due to the potential for serious adverse reactions in a breastfed infant, it is generally advised that women do not breastfeed while taking these medications. Patients should discuss alternative treatments with their healthcare provider if they are breastfeeding.
Who should avoid taking combination of ertugliflozin and sitagliptin?
Ertugliflozin and sitagliptin have important warnings and contraindications. Ertugliflozin should not be used in people with severe kidney problems or those on dialysis, as it can worsen kidney function. Sitagliptin should be used cautiously in people with a history of pancreatitis. Both medications can cause low blood sugar, especially when combined with other diabetes drugs. Patients should be aware of symptoms like dizziness or sweating, which indicate low blood sugar, and should consult their healthcare provider for guidance.
Who should avoid taking combination of Ertugliflozin and Sitagliptin?
Ertugliflozin and Sitagliptin have several important warnings and contraindications. They are not recommended for patients with severe renal impairment or those on dialysis. Ertugliflozin carries a risk of ketoacidosis, dehydration, and lower limb amputation, while Sitagliptin may cause pancreatitis and severe allergic reactions. Both medications should be used cautiously in patients with a history of pancreatitis or heart failure. Patients should be informed of these risks and advised to seek medical attention if they experience symptoms such as severe abdominal pain, dehydration, or signs of infection.
