Ertugliflozin + Metformin
Find more information about this combination medication at the webpages for metformin and ertugliflozin
Type 2 Diabetes Mellitus
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Advisory
- This medicine contains a combination of 2 drugs ertugliflozin and metformin.
- ertugliflozin and metformin are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
None
Controlled Drug Substance
NO
Summary
Ertugliflozin and metformin are used to manage type 2 diabetes, which is a condition where the body doesn't use insulin properly, leading to high blood sugar levels. These medications help control blood sugar, reducing the risk of complications like heart disease and kidney damage. Metformin is often the first choice for treatment, while ertugliflozin is added when more control is needed.
Metformin works by reducing glucose production in the liver and improving insulin sensitivity, which means the body uses insulin more effectively. Ertugliflozin helps remove excess glucose through urine by blocking a protein in the kidneys called SGLT2, which is responsible for glucose reabsorption. Together, they provide a comprehensive approach to managing blood sugar levels.
Metformin is usually taken as 500 mg to 1000 mg twice daily with meals to reduce stomach upset. Ertugliflozin is typically taken as a 5 mg or 15 mg tablet once daily, with or without food. The exact dosage may vary based on individual needs and response, and it's important to follow the healthcare provider's instructions.
Common side effects of metformin include stomach upset, diarrhea, and nausea, which usually improve over time. Ertugliflozin may cause urinary tract infections and increased urination. Both medications can lead to low blood sugar, especially when combined with other diabetes medications. It's important to monitor for these effects and consult a healthcare provider if any severe symptoms occur.
Metformin carries a risk of lactic acidosis, which is a rare but serious condition requiring immediate medical attention. Ertugliflozin may increase the risk of dehydration and urinary tract infections. Both drugs should be used cautiously in people with kidney problems. Contraindications include severe kidney disease for both medications and certain heart conditions for metformin. Always follow healthcare provider instructions.
Indications and Purpose
How does combination of ertugliflozin and metformin work?
Ertugliflozin and metformin work together to lower blood sugar levels in people with type 2 diabetes. Metformin decreases glucose production in the liver and improves the body's sensitivity to insulin, which is a hormone that helps cells absorb glucose. Ertugliflozin works by blocking a protein in the kidneys called SGLT2, which helps remove excess glucose from the body through urine. Together, they provide a comprehensive approach to managing blood sugar by targeting different mechanisms in the body.
How does combination of Ertugliflozin and Metformin work?
Ertugliflozin and Metformin are medications used together to help control blood sugar levels in people with type 2 diabetes. Ertugliflozin works by helping the kidneys remove glucose (sugar) from the bloodstream through urine. It belongs to a class of drugs called SGLT2 inhibitors, which block a protein in the kidneys responsible for reabsorbing glucose back into the blood. Metformin, on the other hand, works by decreasing the amount of glucose produced by the liver and improving the body's sensitivity to insulin, which helps cells use glucose more effectively. Together, these medications help lower blood sugar levels, which can reduce the risk of diabetes-related complications. It's important to follow a healthcare provider's instructions when using these medications, as they are part of a broader diabetes management plan that includes diet and exercise.
How does combination of Metformin and Ertugliflozin work?
Metformin works by decreasing glucose production in the liver, reducing intestinal absorption of glucose, and improving insulin sensitivity, which helps the body use insulin more effectively. Ertugliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, works by preventing the kidneys from reabsorbing glucose back into the bloodstream, leading to increased glucose excretion in the urine. Both medications help lower blood sugar levels in people with type 2 diabetes, but they do so through different mechanisms, making them complementary when used together.
How effective is combination of ertugliflozin and metformin?
Clinical studies have shown that ertugliflozin and metformin effectively lower blood sugar levels in people with type 2 diabetes. Metformin has been a standard treatment for many years, with evidence supporting its ability to reduce A1C levels and improve insulin sensitivity. Ertugliflozin has been shown to further enhance blood sugar control by promoting glucose excretion through urine. When used together, these medicines provide a complementary approach, targeting different mechanisms to achieve better overall blood sugar management. The combination has been proven effective in clinical trials, demonstrating significant reductions in A1C levels compared to placebo.
How effective is combination of Ertugliflozin and Metformin?
The combination of Ertugliflozin and Metformin is used to help control blood sugar levels in adults with type 2 diabetes. Ertugliflozin works by helping the kidneys remove glucose from the bloodstream, while Metformin decreases glucose production in the liver and improves the body's sensitivity to insulin. Together, they can be more effective in managing blood sugar levels than either drug alone. However, the effectiveness can vary based on individual health conditions and should be used as part of a comprehensive treatment plan that includes diet and exercise. It's important to consult with a healthcare provider to determine the best treatment approach.
How effective is combination of Metformin and Ertugliflozin?
Clinical trials have demonstrated that both metformin and ertugliflozin effectively lower blood sugar levels in individuals with type 2 diabetes. Metformin has been shown to decrease hepatic glucose production and improve insulin sensitivity, while ertugliflozin increases urinary glucose excretion by inhibiting SGLT2 in the kidneys. Studies have shown that when used together, these medications provide a complementary effect, leading to better glycemic control than either drug alone. The combination has also been associated with weight loss and a reduced risk of diabetes-related complications.
Directions for Use
What is the usual dose of combination of ertugliflozin and metformin?
The usual adult dose for metformin is typically 500 mg to 1000 mg taken twice daily with meals, but it can vary based on individual needs and response. Ertugliflozin is usually taken as a 5 mg or 15 mg tablet once daily, with or without food. The exact dosage for each person may differ, and it's important to follow the healthcare provider's instructions. Both medications are adjusted based on blood sugar levels and kidney function, ensuring effective and safe treatment.
What is the usual dose of combination of Ertugliflozin and Metformin?
The usual dose of the combination of Ertugliflozin and Metformin can vary based on individual health needs and the specific formulation prescribed by a healthcare provider. Generally, the starting dose might be Ertugliflozin 5 mg with Metformin 500 mg, taken once daily with meals to reduce stomach upset. However, the dose can be adjusted by a healthcare provider based on the patient's response and tolerance. It's important to follow the specific dosing instructions provided by your healthcare provider or pharmacist.
What is the usual dose of combination of Metformin and Ertugliflozin?
For metformin, the usual adult starting dose is 500 mg taken two or three times a day with meals, and it can be increased gradually to a maximum of 2,000 mg per day, depending on the patient's response and tolerance. Ertugliflozin is typically started at 5 mg once daily, and the dose may be increased to 15 mg once daily if needed. Both medications are used to manage type 2 diabetes and are often adjusted based on individual patient needs and responses. It's important to follow the healthcare provider's instructions for dosing.
How does one take combination of ertugliflozin and metformin?
Metformin should be taken with meals to reduce stomach upset, while ertugliflozin can be taken with or without food. It's important to follow the healthcare provider's instructions regarding dosage and timing. People taking these medications should maintain a balanced diet and monitor their blood sugar levels regularly. There are no specific food restrictions, but it's advisable to avoid excessive alcohol consumption, as it can increase the risk of lactic acidosis with metformin. Regular follow-ups with a healthcare provider are essential to ensure effective management of diabetes.
How does one take combination of Ertugliflozin and Metformin?
Ertugliflozin and Metformin are medications used to help control blood sugar levels in people with type 2 diabetes. When taking this combination, it's important to follow your healthcare provider's instructions. Typically, the medication is taken by mouth, usually once or twice a day with meals to reduce the risk of stomach upset. Ertugliflozin works by helping the kidneys remove glucose from the bloodstream, while Metformin decreases glucose production in the liver and improves the body's sensitivity to insulin. Always take the medication at the same time each day to maintain an even level in your bloodstream. Do not crush or chew the tablets, as this can affect how the medication is absorbed. It's crucial to continue following a healthy diet and exercise plan while taking these medications. Regular monitoring of blood sugar levels is also important to ensure the medication is working effectively. If you have any questions or experience side effects, consult your healthcare provider for guidance.
How does one take combination of Metformin and Ertugliflozin?
Metformin should be taken with meals to reduce gastrointestinal side effects, while ertugliflozin can be taken with or without food. Patients are advised to follow their healthcare provider's dietary recommendations, which typically include a balanced diet to help manage blood sugar levels. It's important to stay hydrated, especially when taking ertugliflozin, as it can cause increased urination. Patients should avoid excessive alcohol consumption, as it can increase the risk of lactic acidosis with metformin and affect blood sugar levels.
For how long is combination of ertugliflozin and metformin taken?
Ertugliflozin and metformin are typically used as long-term treatments for managing type 2 diabetes. The duration of use depends on individual response and the healthcare provider's recommendations. These medications are often part of a lifelong management plan to control blood sugar levels and reduce the risk of complications. Regular monitoring and follow-up with a healthcare provider are important to assess effectiveness and make any necessary adjustments to the treatment plan.
For how long is combination of Ertugliflozin and Metformin taken?
The combination of Ertugliflozin and Metformin is typically taken as a long-term treatment for managing type 2 diabetes. The duration of treatment depends on individual health needs and how well the medication helps in controlling blood sugar levels. It is important to follow the healthcare provider's instructions and have regular check-ups to assess the effectiveness and adjust the treatment as necessary. Always consult with a healthcare professional before making any changes to the medication regimen.
For how long is combination of Metformin and Ertugliflozin taken?
Metformin and ertugliflozin are typically used as long-term treatments for managing type 2 diabetes. They are not cures for diabetes but are part of a comprehensive management plan that includes lifestyle changes such as diet and exercise. Patients are advised to continue taking these medications as prescribed by their healthcare provider, even if they feel well, to maintain blood sugar control and prevent complications. Regular monitoring and follow-up with a healthcare provider are essential to assess the effectiveness and adjust treatment as needed.
How long does it take for combination of ertugliflozin and metformin to work?
Ertugliflozin and metformin work together to help control blood sugar levels in people with type 2 diabetes. Metformin, which is a biguanide, usually starts to lower blood sugar within a few days, but it may take up to two weeks to see the full effect. Ertugliflozin, which is a sodium-glucose co-transporter 2 (SGLT2) inhibitor, can start working within a few hours after the first dose. However, the full benefits of the combination may take a few weeks to become noticeable. Both medicines work best when taken consistently as prescribed.
How long does it take for combination of Ertugliflozin and Metformin to work?
The combination of Ertugliflozin and Metformin typically begins to lower blood sugar levels within a few days of starting the medication. However, it may take a few weeks to see the full effect on blood sugar control. It's important to follow your healthcare provider's instructions and continue monitoring your blood sugar levels regularly.
How long does it take for combination of Metformin and Ertugliflozin to work?
Metformin and ertugliflozin both work to lower blood sugar levels in people with type 2 diabetes, but they do so in different ways. Metformin typically begins to work within a few days, but it may take up to two weeks to see the full effect on blood sugar levels. Ertugliflozin, on the other hand, starts to work within hours of the first dose, as it helps the kidneys remove excess glucose through urine. Together, these medications can provide a more comprehensive approach to managing blood sugar levels, with metformin improving insulin sensitivity and ertugliflozin reducing glucose reabsorption.
Warnings and Precautions
Are there harms and risks from taking combination of ertugliflozin and metformin?
Common side effects of metformin include stomach upset, diarrhea, and nausea, which usually improve over time. Ertugliflozin may cause urinary tract infections and increased urination. Both medicines can lead to low blood sugar, especially when combined with other diabetes medications. Significant adverse effects include lactic acidosis, which is a rare but serious condition associated with metformin, and dehydration or kidney problems linked to ertugliflozin. It's important to monitor for these effects and consult a healthcare provider if any severe symptoms occur.
Are there harms and risks from taking combination of Ertugliflozin and Metformin?
Yes, there are potential harms and risks when taking a combination of Ertugliflozin and Metformin. Ertugliflozin is a medication that helps lower blood sugar levels in people with type 2 diabetes by helping the kidneys remove glucose from the bloodstream through urine. Metformin also helps control blood sugar levels by decreasing glucose production in the liver and improving the body's sensitivity to insulin. Possible side effects of taking these medications together include: 1. **Low blood sugar (hypoglycemia):** This can occur if the combination is taken with other diabetes medications or if meals are skipped. 2. **Dehydration:** Ertugliflozin can cause increased urination, which may lead to dehydration if fluid intake is not sufficient. 3. **Genital infections:** Ertugliflozin can increase the risk of yeast infections in the genital area. 4. **Lactic acidosis:** A rare but serious side effect of Metformin, where lactic acid builds up in the blood, which can be life-threatening. 5. **Kidney problems:** Both medications can affect kidney function, so regular monitoring by a healthcare provider is important. It's important to discuss any concerns and potential side effects with a healthcare provider before starting these medications.
Are there harms and risks from taking combination of Metformin and Ertugliflozin?
Common side effects of metformin include gastrointestinal issues such as diarrhea, nausea, and stomach discomfort. Ertugliflozin may cause increased urination, thirst, and urinary tract infections. Both medications can lead to changes in blood sugar levels, with metformin potentially causing lactic acidosis, a rare but serious condition. Ertugliflozin can increase the risk of genital infections and dehydration. Patients should be aware of these side effects and contact their healthcare provider if they experience severe or persistent symptoms.
Can I take combination of ertugliflozin and metformin with other prescription drugs?
Ertugliflozin and metformin can interact with several prescription drugs. Metformin may interact with medications like cimetidine, which can increase metformin levels in the blood, potentially leading to side effects. Ertugliflozin can interact with diuretics, increasing the risk of dehydration. Both drugs can interact with insulin or other diabetes medications, increasing the risk of low blood sugar. It's important to inform healthcare providers about all medications being taken to manage these interactions effectively and adjust dosages if necessary.
Can I take combination of Ertugliflozin and Metformin with other prescription drugs?
Ertugliflozin and Metformin can be taken with other prescription drugs, but it's important to consult with a healthcare provider before doing so. This is because combining these medications with other drugs can affect how they work or increase the risk of side effects. For example, taking them with diuretics (water pills) may increase the risk of dehydration. Additionally, some drugs may affect blood sugar levels, which is important to monitor when taking diabetes medications like Ertugliflozin and Metformin. Always inform your doctor about all the medications you are taking, including over-the-counter drugs and supplements, to ensure safe and effective treatment.
Can I take combination of Metformin and Ertugliflozin with other prescription drugs?
Metformin can interact with medications that affect kidney function, such as certain diuretics and contrast agents used in imaging procedures, increasing the risk of lactic acidosis. Ertugliflozin may increase the risk of hypoglycemia when used with insulin or insulin secretagogues. Both medications require careful monitoring when used with other drugs that affect blood sugar levels. Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions and ensure safe use of metformin and ertugliflozin.
Can I take combination of ertugliflozin and metformin if I am pregnant?
The safety of ertugliflozin and metformin during pregnancy is not well established. Metformin is sometimes used during pregnancy to manage blood sugar levels, but it should only be taken if clearly needed and prescribed by a healthcare provider. Ertugliflozin is generally not recommended during pregnancy due to potential risks to the developing baby. It's important for pregnant women or those planning to become pregnant to discuss their treatment options with their healthcare provider to ensure the safest approach for managing diabetes during pregnancy.
Can I take combination of Ertugliflozin and Metformin if I am pregnant?
It is not recommended to take Ertugliflozin and Metformin during pregnancy. Ertugliflozin is a type of medication known as an SGLT2 inhibitor, which is not advised for use during pregnancy due to potential risks to the developing baby. Metformin, on the other hand, is sometimes used during pregnancy, but only under the guidance of a healthcare professional. It is crucial to consult with your doctor to discuss safer alternatives for managing blood sugar levels during pregnancy.
Can I take combination of Metformin and Ertugliflozin if I am pregnant?
Metformin is sometimes used during pregnancy to manage gestational diabetes, but its safety profile is not fully established. Ertugliflozin is not recommended during pregnancy due to potential risks to the developing fetus, particularly concerning kidney development. Women who are pregnant or planning to become pregnant should discuss their treatment options with their healthcare provider to ensure the safety of both mother and child. Alternative medications may be considered to manage blood sugar levels during pregnancy.
Can I take combination of ertugliflozin and metformin while breastfeeding?
During lactation, metformin is considered relatively safe as it passes into breast milk in small amounts and is unlikely to harm the nursing baby. However, the safety of ertugliflozin during breastfeeding is not well established, and it is generally not recommended due to the lack of data on its effects on the infant. Nursing mothers should consult their healthcare provider to weigh the benefits and risks of continuing these medications while breastfeeding, and alternative treatments may be considered if necessary.
Can I take combination of Ertugliflozin and Metformin while breastfeeding?
According to the NHS, it is generally advised to avoid taking Ertugliflozin while breastfeeding because it is not known if it passes into breast milk and what effects it might have on a nursing infant. Metformin, on the other hand, is considered safe to use while breastfeeding as only small amounts pass into breast milk and it is unlikely to harm the baby. However, it is crucial to consult with a healthcare provider before taking any medication while breastfeeding to ensure it is safe for both you and your baby.
Can I take combination of Metformin and Ertugliflozin while breastfeeding?
There is limited information on the safety of metformin and ertugliflozin during lactation. Metformin is known to be present in breast milk, but its effects on the breastfed infant are not well established. Ertugliflozin's safety during breastfeeding is not well studied, and due to potential risks to the developing kidney, it is generally not recommended. Women who are breastfeeding should discuss the risks and benefits of these medications with their healthcare provider to make an informed decision.
Who should avoid taking combination of ertugliflozin and metformin?
Important warnings for ertugliflozin and metformin include the risk of lactic acidosis with metformin, which is a rare but serious condition that requires immediate medical attention. Ertugliflozin may increase the risk of dehydration and urinary tract infections. Both medicines should be used cautiously in people with kidney problems. Contraindications include severe kidney disease for both medications and certain heart conditions for metformin. It's crucial to follow healthcare provider instructions and report any unusual symptoms promptly to ensure safe use of these medications.
Who should avoid taking combination of Ertugliflozin and Metformin?
People who should avoid taking the combination of Ertugliflozin and Metformin include those with severe kidney problems, as these medications can affect kidney function. Additionally, individuals with a history of serious allergic reactions to either of these drugs should not take them. Pregnant or breastfeeding women should also avoid this combination, as it may not be safe for the baby. It's important for anyone considering this medication to consult with a healthcare provider to ensure it's appropriate for their specific health conditions.
Who should avoid taking combination of Metformin and Ertugliflozin?
Metformin carries a warning for lactic acidosis, a rare but serious condition, especially in patients with kidney impairment or those consuming excessive alcohol. Ertugliflozin is contraindicated in patients with severe renal impairment and can increase the risk of ketoacidosis and lower limb amputation. Both medications should not be used in patients with type 1 diabetes or diabetic ketoacidosis. Patients should be aware of these risks and discuss any concerns with their healthcare provider, ensuring regular monitoring and adherence to prescribed guidelines.
