Erenumab
Migraine Disorders
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Summary
Erenumab is used to prevent migraines, which are severe headaches often accompanied by nausea and sensitivity to light and sound. It helps reduce the frequency of migraine attacks in adults, improving their quality of life.
Erenumab works by blocking a protein called calcitonin gene-related peptide (CGRP), which is involved in the development of migraines. This action helps prevent migraines from occurring by reducing their frequency.
Erenumab is usually administered as an injection once a month. The starting dose for adults is typically 70 mg, but some may require 140 mg monthly, depending on their response to the treatment.
Common side effects of erenumab include injection site reactions, such as redness or pain, and constipation. These effects are generally mild and may improve over time.
Erenumab may cause serious allergic reactions, with symptoms like rash or swelling. It can also cause severe constipation. It should not be used if you have a known allergy to it or its ingredients.
Indications and Purpose
How does erenumab work?
Erenumab works by blocking a protein called calcitonin gene-related peptide (CGRP), which is involved in the development of migraines. Think of CGRP as a key that unlocks migraine symptoms. Erenumab acts like a lock that prevents this key from working, reducing the frequency of migraines. By targeting this specific protein, erenumab helps prevent migraines from occurring. This mechanism makes it an effective treatment for people who experience frequent migraines, helping to improve their quality of life.
Is erenumab effective?
Erenumab is effective in preventing migraines. It works by blocking a protein involved in migraine development. Clinical studies show that erenumab significantly reduces the frequency of migraine days for many people. Patients often experience fewer migraines and improved quality of life. The effectiveness of erenumab can vary from person to person, and it may take a few months to see the full benefits. Always follow your doctor's instructions and discuss any concerns about the effectiveness of your treatment with them.
What is erenumab?
Erenumab is a medication used to prevent migraines. It belongs to a class of drugs called monoclonal antibodies, which are proteins designed to target specific substances in the body. Erenumab works by blocking a protein involved in the development of migraines, helping to reduce their frequency. It is used as a preventive treatment for adults who experience frequent migraines. Erenumab is typically administered as a monthly injection and can be used alone or in combination with other migraine treatments.
Directions for Use
For how long do I take erenumab?
Erenumab is usually used for long-term prevention of migraines. You'll typically take it once a month as an ongoing treatment. The duration of use depends on your response to the medication and your doctor's recommendations. It's important to follow your doctor's instructions and not stop taking erenumab without consulting them. Stopping the medication without medical advice could lead to an increase in migraine frequency. Regular follow-ups with your healthcare provider help ensure the treatment remains effective and safe.
How do I dispose of erenumab?
To dispose of erenumab, use a drug take-back program or collection site at a pharmacy or hospital. This ensures the medication is disposed of safely and doesn't harm people or the environment. If a take-back program isn't available, you can throw it away at home. Remove it from its original container, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it in the trash. Always follow local guidelines for medication disposal.
How do I take erenumab?
Erenumab is usually administered as an injection once a month. It can be given with or without food. The injection is typically done in the abdomen, thigh, or upper arm. If you miss a dose, take it as soon as you remember, unless it's close to your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule. Do not double up on doses. Always follow your doctor's specific instructions on how to take erenumab, and consult them if you have any questions or concerns about your dosing schedule.
How long does it take for erenumab to start working?
Erenumab may start reducing migraine frequency within a month, but it can take up to three months to see the full benefits. Individual responses vary, and some people may notice improvements sooner. Factors like your overall health and how your body responds to the medication can affect how quickly you see results. Keep track of your migraine frequency and severity to help assess the effectiveness of the treatment. Always follow your doctor's instructions and discuss any concerns about your progress with them.
How should I store erenumab?
Store erenumab in the refrigerator between 36°F to 46°F. Keep it in its original packaging to protect it from light. Do not freeze it. If needed, erenumab can be kept at room temperature, up to 77°F, for up to 7 days. Once it reaches room temperature, do not return it to the refrigerator. Always check the expiration date before use and properly dispose of any unused or expired medication. Keep it out of reach of children to prevent accidental use.
What is the usual dose of erenumab?
The usual starting dose of erenumab for adults is 70 mg once a month, administered as an injection. Some patients may require a higher dose of 140 mg monthly, depending on their response to the treatment. Your doctor will determine the appropriate dose for you based on your specific needs and how well you tolerate the medication. Always follow your doctor's dosing instructions and discuss any concerns or side effects you experience while taking erenumab.
Warnings and Precautions
Can erenumab be taken safely while breastfeeding?
The safety of erenumab while breastfeeding is not well-established. It's unclear if erenumab is excreted into breast milk. There is limited information on its effects on breastfed infants or milk supply. If you are breastfeeding or planning to breastfeed, discuss the potential risks and benefits with your doctor. They can help determine the safest treatment options for managing migraines while nursing. Always consult your healthcare provider before starting or continuing any medication while breastfeeding.
Can erenumab be taken safely while pregnant?
The safety of erenumab during pregnancy is not well-established. There is limited evidence to provide definitive advice about its safety. Animal studies have not shown harm, but human data is lacking. If you are pregnant or planning to become pregnant, discuss the risks and benefits with your doctor. They can help determine the safest treatment options for managing migraines during pregnancy. Always consult your healthcare provider before starting or continuing any medication while pregnant.
Can I take erenumab with other prescription drugs?
Erenumab has no major or moderate drug interactions reported. However, always inform your doctor about all the medications you are taking, including over-the-counter drugs and supplements. This helps prevent any potential interactions and ensures your treatment is safe and effective. If you have concerns about specific drug interactions, discuss them with your healthcare provider. They can provide guidance on whether any adjustments are needed to your medication regimen while taking erenumab.
Does erenumab have adverse effects?
Adverse effects are unwanted reactions to a medication. With erenumab, common adverse effects include injection site reactions, such as redness or pain, and constipation. These effects are generally mild. Serious adverse effects are rare but can include severe allergic reactions. If you experience symptoms like swelling or difficulty breathing, seek medical help immediately. Always inform your doctor about any new or worsening symptoms while taking erenumab. They can help determine if these are related to the medication and suggest appropriate management strategies.
Does erenumab have any safety warnings?
Yes, erenumab has safety warnings. It may cause allergic reactions, which can be serious. Symptoms include rash, itching, or swelling, especially of the face, tongue, or throat. If you experience these, seek medical help immediately. Erenumab can also cause constipation, which may become severe. If you have a history of constipation or bowel problems, inform your doctor. Not adhering to these warnings can lead to serious health issues. Always follow your doctor's advice and report any unusual symptoms while using erenumab.
Is erenumab addictive?
Erenumab is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Erenumab works by blocking a protein involved in migraine development, and this mechanism does not affect brain chemistry in a way that leads to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that erenumab doesn't carry this risk while managing your migraines.
Is erenumab safe for the elderly?
Erenumab is generally safe for elderly patients, but they may be more vulnerable to side effects. Older adults often have multiple health conditions and take various medications, increasing the risk of interactions. Constipation, a common side effect, may be more problematic for the elderly. It's important for elderly patients to discuss their full medical history and current medications with their doctor before starting erenumab. Regular monitoring and follow-up appointments can help ensure the treatment is safe and effective for older adults.
Is it safe to drink alcohol while taking erenumab?
There are no well-established interactions between erenumab and alcohol. However, alcohol can trigger migraines in some people. If you choose to drink, do so in moderation and monitor how it affects your migraines. If you notice an increase in migraine frequency or severity, consider reducing or avoiding alcohol. Always discuss your alcohol consumption with your doctor, as they can provide personalized advice based on your specific health situation and treatment plan.
Is it safe to exercise while taking erenumab?
Yes, it is safe to exercise while taking erenumab. Exercise is generally beneficial for overall health and can help reduce stress, which may lower migraine frequency. However, some people find that intense or strenuous activities can trigger migraines. Listen to your body and adjust your exercise routine as needed. Stay hydrated and avoid overexertion. If you have concerns about exercising while taking erenumab, discuss them with your doctor. They can provide guidance based on your specific health needs.
Is it safe to stop erenumab?
Yes, it is generally safe to stop erenumab, but you should consult your doctor first. Erenumab is used for long-term prevention of migraines, and stopping it might lead to an increase in migraine frequency. There are no withdrawal symptoms associated with stopping erenumab. However, your doctor might suggest a gradual reduction or an alternative treatment to manage your migraines effectively. Always discuss any changes to your medication regimen with your healthcare provider to ensure your condition remains well-managed.
What are the most common side effects of erenumab?
Side effects are unwanted reactions that can occur with medication use. For erenumab, common side effects include injection site reactions, such as redness or pain, and constipation. These occur in a small percentage of users. If you experience these side effects, they are usually mild and may improve over time. If they persist or worsen, contact your doctor. It's important to remember that side effects can vary from person to person, and not everyone will experience them. Always discuss any concerns with your healthcare provider.
Who should avoid taking erenumab?
Erenumab should not be used if you have a known allergy to it or any of its ingredients. This is an absolute contraindication, meaning the drug must not be used due to severe risks. If you experience symptoms like rash, swelling, or difficulty breathing, seek medical help immediately. There are no specific relative contraindications, but always inform your doctor about your medical history and any other medications you are taking. This helps ensure that erenumab is safe and appropriate for you.
